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Targeted suppression of breast cancer cells: the hope, a drug that will eliminate cancer cells without harming healthy cells

In the research of Prof. Cohen-Armon from the Sackler School of Medicine at Tel Aviv University, a mechanism was identified in the cell that can be attacked only by cancer cells * The research has so far been done in mice and cell cultures

Breast cancer tumor
Breast cancer tumor

From a study published today in the journal Breast Cancer Research, it appears that substances previously developed to prevent nerve cell death in the brain after a stroke effectively eliminate breast cancer cells without harming healthy cells. These substances have been tested in research on types of breast cancer that are not known to develop on a hereditary basis. The research was conducted in the laboratory of Prof. Cohen-Armon from the School of Medicine at Tel Aviv University, in collaboration with the doctoral student Asher Castiel in the research group of Prof. Yizraeli from the Cancer Research Institute at the Sheba Medical Center.

The group performed experiments on breast cancer cells in cultures and in mice that were injected with the cancer cells. At the same time, experiments were carried out with dividing healthy cells, which included fetal connective tissue and epithelial tissue cultures. The experiments in the cell cultures proved that the tested group of substances inhibits cell division (G2/M arrest) both in healthy dividing cells and in cancer cells. However, while the damage to cancer cells is irreversible and is accompanied by rapid cell death, in healthy cells there is a mechanism that "overcomes" the delay in cell division within hours, and these cells survive and continue to divide even in the presence of the substance, similar to cells that were not treated with the substance at all. Thus, a group of substances developed more than a decade ago to prevent cell death under stress conditions that cause DNA damage, was discovered to very efficiently destroy breast cancer cells without harming healthy cells. The tested substances do not damage healthy dividing cells, such as epithelial cells, nor do they damage non-dividing cells, such as nerve cells and heart muscle cells. Ramot Company, the commercialization company of Tel Aviv University, registered a patent for the use of these substances for the purpose of curing breast cancer.

The killing of breast cancer cells by these substances was also proven in experiments on mice, carried out by the veterinarian Dr. David Castel, with the approval of the Committee for Experiments in Medicine from Tel Aviv University. The mice were injected with human breast cancer cells, with some treated with one of the substances tested in the cell cultures. The substance was released in a slow release over two weeks from subcutaneously implanted pumps. The cancerous tumors developed in untreated mice. In contrast, the treatment completely prevented or delayed the development of tumors of the injected breast cancers. It is important to note that in these experiments no changes were observed in the behavior of the treated mice, nor were any signs of disease or side effects that indicate damage to their vitality or longevity observed.

According to Prof. Cohen-Armon, identifying the substance's mechanism of action in breast cancer cells may form the basis for targeted drug treatment in other types of cancer. However, we have a long and bumpy road ahead of us in our attempt to turn this discovery into a marketed drug.

10 תגובות

  1. Come on.. another one who is unable to understand that where the conventional is unable to treat a simple fungus on the foot, you dare to speak slander about the alternative.. or the supplements..
    Go out and learn.. complementary medicine and not deprivation.. a different and useful way and you didn't hurt.. why get dirty.. there is enough alchemy in the air..

  2. Following a question from a friend, regarding anti-cancer pills produced from algae, I previously checked information on the net about new anti-cancer substances.
    It turns out that dozens if not hundreds of substances are known that have an inhibitory effect on the growth of cancer cells in tissue cultures.
    The problem is that usually they fail to see the same results in an in vivo experiment.
    This does not prevent all kinds of followers of "natural medicine" from selling and recommending all kinds of so-called natural preparations, and taking advantage of the plight of desperate patients or people anxious about their health! This is usually accompanied by all kinds of conspiracy theories about evil doctors, who are unwilling to recognize natural remedies because it is impossible to make money from them.
    My advice and demand from all these believers is, either you show us successive studies conducted according to scientific standards that prove the medical effect of these substances and explain the mechanism of action in the body, (and then you will win all possible glory), no, sit back and let real scientists promote the research.
    It is also worth adding that the claim of all kinds of "natural" and "alternative" therapists that it is impossible to check the effectiveness of their treatments with scientific testing tools, is vanity and short-sightedness and is nothing more than an attempt to steal the minds of the innocent.

  3. Yigal.
    God (is it someone from the Shin Bet?) should forgive all the alternative healers who give false hope to the sick and not a few of them also collect a lot of money from people in need.

  4. Natural agents that work on G2/M arrest

    A substance from garlic (one of 4-5 anti-cancer substances in garlic!!)
    Diallyl disulfide-induced G2/M arrest of human gastric cancer

    Materials from Tion adhesive against 3 types of melanomas - research from the Hebrew University - other studies have shown that Tion is also active against other types of cancer, including cervical cancer
    Induction of G(2)/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines

    And of course substances from aloe vera, which treats almost every type of cancer,
    We also conducted an experiment on patients that showed double survival for aloe and chemo users compared to only chemo (chemo is of course only harmful)
    Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation

    In short, what I'm coming to say is that there are harmless natural substances in nature to treat any biological mechanism that stops cancer, just because you can't make a patent/make money that way doesn't mean you have to take ineffective and toxic synthetic substances.

    God forgive the doctors and the death industry of chemotherapy

  5. From the name of the researcher, it can be concluded that the drug will be suitable for other types of cancer (at least for prostate cancer 🙂 )

    And a little more seriously - two more things:
    1. The substance was originally developed (as written) - for the purpose of treating nerve cells. What is not written is that the company that developed it registered a patent on it and this is the reason why the newly filed patent is for the use only, but this use will only be possible if the patent holders of the material allow it.
    2. It is also interesting, because at the same time as this publication, an American company whose name I do not remember (I heard the news on the radio) also announced the development of nano materials that are also suitable for targeted cancer treatment. Today, these substances are already entering the phase of human trials (if I remember correctly - a group of about 25 patients).

  6. According to the scriptures, it is not clear why the road is long.
    After all, if it works, then they fail a little in the development of a drug and make billions, and if it doesn't work, then they publish articles claiming that it works.

  7. All the best and good luck with the revelations.
    God willing, you will discover a complete cure for this terrible disease.

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