Cancer research - basic

Heart disease and cancer and drug treatments – interactions

Between the heart and cancer: Technion researchers reveal surprising interrelationships between heart disease and cancerous tumors

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Researchers at the Ruth and Baruch Rappaport Faculty of Medicine at the Technion present complex interrelationships between heart disease and cancer, in the hope that the findings will lead to improved treatment of both diseases.
Microsoft researchers have developed an artificial intelligence system called Cell2Sentence-Scale. Think of it as GPT-chat, but for the language of cells and the molecules they are made of.

Artificial intelligence developed a new hypothesis for treating cancer – and verified it in laboratory experiments

Microsoft's Cell2Sentence-Scale Model Identifies Silmitasertib as a CK2 Inhibitor That Increases Antigen Presentation in "Cold" Cancer Cells – A New Insight Tested in the Lab and Demonstrates AI Research Creativity
Prof. Ronit Saatchi Fainero. Photo: Tel Aviv University spokesperson

Attacking brain tumors

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Prof. Ronit Sacchi-Painero identified two key proteins – CCL2 and P-Selectin – that are involved in cancer cell entry into the brain. Blocking either axis significantly reduced metastatic burden in mouse models and in vitro systems.
From right: Dr. Naama Darzi, Prof. Ayelet Erez, Dr. Natalie Rosenfeld and Dr. Elizaveta Bab-Dinitz. Photo by Weizmann Institute Spokesperson

It's all in the head: Blocking the communication channel between the brain and liver may prevent life-threatening weight loss in cancer patients

Research at the Weizmann Institute of Science demonstrates how communication between the brain and the body's organs plays a critical role in health and disease
Immune system cells attack a cancer cell. Illustration: depositphotos.com

The gene that maximizes sunlight – and may eliminate cancer cells

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Scientists have discovered that SDR42E1, a tiny gene linked to vitamin D absorption, could be the key to treating cancer: When it was turned off in cancer cells, the tumor stopped growing.
An Egyptian mummy excavated from the tombs of the pharaohs. Illustration: depositphotos.com

The mold that caused the curse of the pharaohs becomes a weapon against leukemia

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Scientists have managed to engineer compounds from the mold Aspergillus flavus that defeat leukemia cells – signaling hope for new drugs from nature
Leukemia. Illustration: depositphotos.com

The blood test that will identify the risk of leukemia – and may replace bone marrow aspiration

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Just days after their laboratories were damaged in an Iranian attack, Prof. Liran Shlush and Prof. Amos Tanai publish groundbreaking findings that are expected to advance the field of blood cell medicine.
T cells attack a cancer cell. Illustration: depositphotos.com

The weapon against cancer: T cells based on chip manufacturing technology

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Illustration: depositphotos.com

"The Early Warning Signs of Cancer: Epigenetic Discoveries That Inspire Hope"

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New study reveals that cancer risk may be determined before birth, suggesting new directions for diagnosis and treatment
Transporting medicines. Illustration: depositphotos.com

Innovative technology for biological nanoparticles enables combined treatment against cancerous tumors

Researchers from Tel Aviv University have developed an innovative platform based on nanoparticles, which enables the precise transport of two drugs at the same time to cancerous tumor sites, while improving treatment efficiency and reducing toxicity to healthy cells.
Starving cancer through sugar deprivation. The image was prepared using DALEE and is not a scientific image

Breakthrough in brain cancer treatment: starving cancer cells causes them to burn themselves

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Prof. Carmit Levy and Prof. Yaron Carmi

Researchers from Tel Aviv University have discovered a new cancer mechanism, the activation of which eliminates cancerous tumors

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Prof. Carmit Levy: Immunotherapy has revolutionized cancer treatment," explains Prof. Carmi, "but about 50% of patients do not respond to the standard treatment - the PD-L1 protein. We found a new protein Ly6a against which treatment with an antibody
A sample from a tumor of a human patient with the most common lung cancer (adenocarcinoma). The presence of senescent cells expressing the proteins P16 (in red) and PD-L1 (in green) can be detected. The cell nuclei in the sample are marked in blue

to open blockages in the immune system

cancer cell Illustration: depositphotos.com

What predicts your cancer type?

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genetic scan. Illustration: depositphotos.com

Artificial intelligence revealed cancer causes hidden in "junk" DNA

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Research at the University of Sydney suggests that non-coding DNA, which makes up 98% of our genome and was previously considered "junk" – that is, lacking a defined function or redundant, may play a crucial role in cancer diagnosis and treatment.
Cells with cancerous p53 proteins (in red), in the presence of the accompanying protein DNAJA2 (left) and in the presence of its version without a "hairpin" (right). In its presence, the structure of the cancerous proteins is stabilized and they do not stick to each other and therefore remain scattered throughout the cell. In its absence, the cell is not colored red since the proteins form aggregates (red dots) that the cell can recognize and destroy (in blue - the genetic material in the cell nuclei)

stick a pin in the tumor

Weizmann Institute of Science scientists have discovered a new cellular mechanism for identifying proteins whose 3D structure has been unraveled, thereby revealing a targeted target for cancer treatment
The skulls were examined using microscopic analysis and CT scanning. Credit: Tondini, Isidro, Camaros, 2024.

A 4,000-year-old Egyptian skull reveals surgical attempts to treat cancer

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Scientists were amazed by the discovery of cut marks around cancerous tumors on an ancient Egyptian skull, which allowed them to better understand how the ancient Egyptians tried to treat the disease
Brain cancer cells. On the right: cells in which the gene coding for 4EBP was silenced that failed to grow a tumor, on the left: the control cells in which a tumor is detected. Credit: Dr. Tal Levy

Glucose starvation also as an anti-cancer treatment

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A new approach to treating brain cancer forces glucose-starved cancer tumor cells to burn themselves out. The method was developed in the laboratory of Prof. Barak Rothblatt at Ben-Gurion University in the Negev and is based on a decade of research
The polymer conjugated to the peptide and the drug (P-Esbp-DOX) binds to the E-selectin protein, which is expressed on the surface of endothelial cells that line the blood vessels in the tumor environment, enters the cells, releases the drug inside them and kills them.

inhibit the migration of cancer cells

Researchers have developed polymers that bind to proteins that play a key role in cancer and inflammation, thus preventing - in mice - the formation of metastases and slowing down the progression of arteriosclerosis and hepatitis
Advances in cancer immunotherapy. The image was produced by DALLE 3 artificial intelligence software and is intended for impressions. It should not be seen as a scientific picture

Technion researchers present a significant improvement in predicting the success of immunotherapy treatments

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The technology developed by Prof. Yuval Shaked's research group was registered as a patent and is now in the process of being commercialized
DNA sequencing. Illustration: depositphotos.com

Proteins in the cancer network

Researchers are trying to find treatments adapted to protein networks that characterize cancer tumors
Histological sections of the leg muscles without injury (left) and five days after it (center, right) in a control mouse and a transgenic mouse. It can be seen that the area of ​​the muscle fibers that develop after the injury is smaller in the transgenic mouse, which indicates a disturbance in the differentiation of the stem cells into muscle cells

overcome the damage

Researchers have discovered that two epigenetic events (removing and adding methyl from DNA) lead to the differentiation of stem cells into muscle cells and thus to the regeneration and healing of muscles after their injury
The working principle of W. Photo: Ariel University

A robotics system to eradicate lung cancer will allow live imaging during examination and treatment

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The error rate of the existing biopsy tests is 30%. Mistakes that are fatal because the test turns up clay but the cancer exists and continues to spread. Good imaging can improve accuracy
From 0 to 100%: the prediction provided by the model for metasynergy between different drugs

Drug combination in the fight against cancer: an innovative approach that combines biology, chemistry and artificial intelligence

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Electron microscope image of a lymphocyte cell on the surface of the chip. Photo: Estee Toledo and Dr. Guillaume Le Soux.

Cells, chips - and cancer research - the National Science Foundation

The ability of the cells of the immune system to inhibit the cancer cells depends to a large extent on the distance between the receptors by means of which they check and identify the "suspicious" cell
A new study by Prof. Ofra Bani from the School of Pharmacy at the Hebrew University of Jerusalem and Dr. Sharon Marims - dermatology specialist and senior physician at the dermato-oncology clinic at the Hadassah Medical Center and the Hadassah Cancer Research Institute, published in Science Translational Medicine courtesy of the Hebrew University

A new way to solve side effects of cancer treatment

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Researchers at the Hebrew University and the Hadassah Medical Center have developed an ointment to treat the severe side effects of targeted cancer treatment and significantly improve the quality of life of patients.
immunotherapy. Illustration: depositphotos.com

Development of new biological sensors to assess cancer patients' responses to treatments

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A team of researchers from Ben-Gurion University of the Negev has developed a breakthrough technology that includes a revolutionary new test that will predict the response of cancer patients to immunotherapy with a higher percentage of accuracy than existing technologies. The results of the study have been published
Ovarian cancer. Illustration: depositphotos.com

The protein that helps the enemy

A certain essential protein increases the expression of another protein in cancer cells in the uterus - and this transforms its skin, encourages them to divide and thus contributes to the spread of the tumor
The thinness of the cancer. Illustration: depositphotos.com

Why do cancer patients lose weight?

The institute's scientists reveal how cancer leads to fatal emaciation and point the way to treatment
Pancreatic cancer. Illustration: depositphotos.com

A breakthrough in the study of deadly pancreatic cancer

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Hebrew University researchers have discovered the molecular mechanism that allows pancreatic cancer to metastasize and become fatal. The discovery offers new treatment methods for the first time
The study was selected to appear on the cover of the March 2023 issue of the scientific journal Science Immunology

Put a leg to cancer

Prof. Martin Kopik. Photo: Tel Aviv University spokesperson

A new discovery in the mechanism of DNA duplication in yeast

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The researchers believe that they have succeeded in finding all the roles played by the ELG1 gene. The gene in question is evolutionarily conserved even in humans and mutations in it cause cancer, understanding its meaning in yeast can help
Breast tumors that were treated with the drug cisplatin (second and fourth row) compared to tumors that were not treated this way (top and third row)

Repairing the cancerous growth

The creation of double-strand breaks in the DNA of certain cancer cells may help inhibit the growth
Tel Aviv University's development for the IGEM competition - simulation. Photo: Tel Aviv University spokesperson

Success for the Israeli national teams in the iGEM global competition

The Technion team for the iGEM synthetic biology competition that took place at the end of October in Paris: Technology to stop hair loss caused by chemotherapy * Students from Tel Aviv University won a gold medal for a new development that enables planning
tumor. Image: depositphotos.com

A combination of ultrasound and nanotubes allows the destruction of cancerous tumors without the need for invasive treatment

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The researchers explain that today, the accepted method of treating cancer is surgical removal of the tumor, in combination with complementary treatments (chemotherapy, immunotherapy, etc.). Therapeutic ultrasound is a non-invasive alternative to destroying the cancerous tumor instead of surgery
immunotherapy. Image: depositphotos.com

Trying to treat cancer - and contributing to its aggressiveness

Immunotherapy treatment may cause the spread of cancerous tumors
Sports activity is also good against cancer. Image: depositphotos.com

The sport defeats the cancer through increased production of glucose

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Researchers from Tel Aviv University discovered that aerobic activity may reduce the risk of metastatic cancer by 72%
The search for fungi in cancer. Illustration: Studio Ella Maro

The fungi that hide inside cancerous tumors

Weizmann Institute of Science scientists and their research partners have mapped the presence of fungi in 35 different types of cancer ■ The fungi that live inside the cancerous tumors may facilitate the detection, diagnosis and perhaps even the treatment of cancer
From the right: Vadim Padiuk, Dr. Efrat Shema, Dr. Noah Pirat and Nir Erez. accurate and meticulous

A drop of blood to diagnose cancer

Weizmann Institute of Science scientists presented the possibility of reliable and accurate blood tests for cancer diagnosis
Blood test to detect cancer. Image: depositphotos.com

A simple blood test to detect cancer instead of invasive tests

Prof. Yuval Ebenstein's laboratory was announced as one of the most advanced in Europe in the research and development of technological solutions for cancer
Glioblastoma tumor in the brain - the tumor is marked in white, the astrocytes are marked in blue. Credit: Tel Aviv University

Researchers have succeeded in neutralizing the energy source of the deadly glioblastoma brain cancer tumor, thereby causing its disappearance

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In experiments conducted on mice, it was found that in the presence of the energy source (brain cells called astrocytes) the tumor was 100% fatal, and all the animals that got sick died within 4-5 weeks of its appearance. When the researchers disappeared the astrocytes, in

Anti-cancer wall

A small molecule that inhibits the spread of cancer metastases - an original development by researchers at the Technion, the Netherlands and the UK
A small vesicle that knows how to inhibit the binding of PD-1/PD-L1 and remind the immune system that it needs to attack the cancer. Screenshot from the video. Dr. Rita Acúrcio

A small molecule that will make the immunological treatment of cancer accessible to all patients

Prof. Ronit Sachi-Painero: "I believe that in the future the small molecule will be available and will make immunological treatment accessible and effective for cancer patients."
Cancer mutations. Image: depositphotos.com

A fast, accurate and cost-effective method for detecting cancer-causing mutations

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The new technology we developed provides accurate data on the nature of the mutation based on the RNA sequencing of the tumor only - that is, without the need for DNA sequencing of the tumor and any sequencing of the healthy tissue
Right: Immune clusters in the liver of a mouse containing ILCs, and within them cancer cells (in red). On the left: immune clusters in the liver of a mouse from which ILCs have been removed, and within them cancer cells. The cancer cells thrive more in the mouse liver which contains ILCs

The immune system gets tired - and the cancer spreads

Pools of immune system cells taken from patients and mice with liver cancer and melanoma, partly composed of tired immune cells
A conceptual illustration of the chess battle between the cancer cells and the anti-cancer drugs. Most cancer deaths are related to the development of drug resistance and the formation of metastases. In both processes, the cancer cells face difficult and new challenges and a strain: finding a bypass for the drug, or a way to adapt to a foreign and hostile tissue. Unfortunately, the cells often manage to overcome these challenges. How does this happen? This is a complex process, and among other things, the cells go through a process of learning, which involves trial and error, while searching among a large number of configurations and internal states. The theory of learning theory constitutes a mental and mathematical framework for understanding these processes. A review of the current literature shows that basic concepts of learning theory provide an explanation for results that do not correspond to the popular concept. Linking the search process to a concrete mathematical model demonstrates its feasibility. (Illustration: Harel Spring)

Lethal learning: a new interpretation of adaptive mechanisms of cancer cells

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Natural cancer antibodies (green) bind to ovarian cancer cells. Cell nuclei in blue. Photographed using a confocal microscope

The new players in the war on cancer

Our immune system has a powerful and accurate weapon to destroy bacteria and viruses. It is possible that in the future it will also be possible to harness it against malignant tumors
Using nanoparticles to fight cancer. Courtesy of the researchers, University of Tokyo

Using nanoparticles to fight cancer

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Researchers have recently succeeded in developing innovative bio-nanoparticles derived from corn designed to tune into and destroy cancer cells, thanks to the body's own immune system
Cancer cells are marked with luminescent detector molecules developed in Prof. Margolis' laboratory

The sunrise of the detector warns of cancer

An advanced molecular structure may detect and report intracellular activity that may cause cancer
The chemotherapy treatment increases the secretion of LOX from T cells, and as a result the extracellular environment in the lungs changes in a way that encourages the formation of metastases. Photo: Technion spokespeople

Cancer metastases sometimes form following successful chemotherapy treatment

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