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T cells

The cover photo on the issue: Cell Host & Microbe This is how the bacteriophages (in purple) affect the function of the bacteria by reversing the DNA - a reversal that changes their effect on the immune system. This effect is demonstrated by changing the color of the bacteria from yellow to green. Illustration credit: Tomm Blum

Gut bacteria are able to change their 'software' in response to inflammation, which may affect the immune system

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The intestine is a very dynamic organ that is constantly changing structurally, mechanically and chemically, and the intestinal bacteria are required to cope with this dynamism. One of the features that may help them in this is plasticity - the ability to undergo rapid genomic changes in response to changes in environmental conditions
Battle team: A dendritic cell (right) and a T cell connected by BiCE antibody (in yellow). were produced from a lymph node of a mouse with skin cancer

Together we will win: combining forces between the cells of the immune system may lead to improved cancer treatments

Weizmann Institute of Science scientists have developed a new approach to immunotherapy based on communication between the cells of the immune system
Cancer treatment. Illustration: depositphotos.com

Break the boundaries of immunotherapy

The method that may make the new generation of cancer treatments accessible to more patients
The team of researchers. From right to left: Peleg Ryder, Diana Resoloniriana and Dr. Yaron Karmi Photo: Courtesy of Tel Aviv University.

Researchers have succeeded in developing an immunotherapy treatment platform that may be suitable for many types of cancer

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The immune system attacks invading viruses. Illustration: shutterstock

An international study was able to identify one of the factors that mediates the weakening of the immune system

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Nobel Prize for Medicine 2018: Harnessing the immune system to fight cancer

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Growing cells in "microbars" - surfaces containing thousands of niches smaller than the thickness of a hair. At the beginning of the experiment, one or two T cells were inserted into some of the "micro-bars", while in others a larger number was inserted - up to ten cells per "bar". Illustration: Weizmann Institute

How many cells does it take to produce memory?

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Laboratory flasks containing thousands of white blood cells from a patient who developed "immune tolerance" to the donor after a bone marrow transplant. The cells show no signs of rejection of the donor cells (three columns on the left), but secrete chemicals that indicate rejection (indicated in red) when exposed to the cells of a third person (three columns on the right). Source: Weizmann Institute magazine.

Education for tolerance

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Cell T (in red) selects cell B (in blue) for the "training camp". In green - B cells lacking ICAMs. Photographed using a two-photon laser scanning microscope. Source: Weizmann Institute magazine.

Corrective immune discrimination

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CAR T cells attack a cancer cell. Source: Rita Elena Serda, Duncan Comprehensive Cancer Center at Baylor College of Medicine, National Cancer Institute, National Institutes of Health.

The army to destroy cancer

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On the left: a cancerous tumor under a microscope: the infiltration of normal T cells (purple) into the tumor tissue is not different from that of T cells that were grown under conditions of oxygen deficiency (green). Right: The amount of the enzyme "granzyme B" (red), which kills cancer cells, is much greater in T cells grown in a low-oxygen environment (top) compared to normal T cells (bottom). Source: Weizmann Institute magazine.

Combat fitness for cells

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From the right: Prof. Avraham Ben-Nun, Prof. Yehiel Shai, Dr. Nathalie Kaushensky and Omari Fingold. Inhibitory effect

To take advantage of the infection mechanism of the AIDS virus to fight autoimmune diseases

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T cell in the bloodstream. Illustration: shutterstock

Getting closer to a universal flu vaccine

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immune system cells. Source: Wikimedia Commons

No entry to HIV / Carl John and Bruce Levine

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immune system cells. Source: Wikimedia Commons

A new ally against cancer / Eric von Hoff

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A T-type white blood cell (right) and a red blood cell

Focus on the goal

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Psoriasis of the nail

The Technion researchers discovered a subset of cells that suppress diseases, which is within a group of cells that cause diseases

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immune system cells. Source: Wikimedia Commons

Rambam and Harvard Medical School are launching a joint research program: a cancer vaccine

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Ceasefire

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