In this disease, the body produces substances similar to those found in cannabis, which damage the kidney * University researchers have found a way to improve the medical treatment of diabetic kidney disease, which affects approximately 30% of diabetics in the world. The new method that is adapted to each patient can prevent the damage, and even the development of the disease
Changes in the amount and type of food we eat may affect the activity of the systems that encourage food storage, metabolism and energy accumulation. Excess sugar and fat, for example, can increase the activity of systems in the body, thereby damaging organs and causing various diseases. For the first time, a new study led by Prof. Yossi Tam, Dr. Liad Hinden, and the doctoral students Majdulin Ahmed and Charlin Hamed From the Institute of Drug Sciences, the School of Pharmacy in the Faculty of Medicine at the university, found a connection between the activity of two systems in the body and the development of diabetic kidney disease, which affects approximately 30% of diabetics in the world. The findings were published in the international journal Nature Communications. Offer new ways to deal with the disease to prevent the damage.
The team of researchers examined the relationship between the endocannabinoid system, which is activated by the cannabis plant and is responsible for maintaining internal balance in relation to changes in the external environment, and the mTORC1 protein coupling system in the kidney. The goal was to understand how this relationship leads to the development of diabetic kidney disease and what is its effect on the health status and normal metabolism. As of today, no research has linked the operation of these two systems with reference to diabetic kidney disease or the normal functioning of the kidney. "The research was carried out in animal models and tissue cultures bAcceptable research methods. First, we had a pharmacological and genetic effect on each of these systems, and then we tested the metabolic function of the kidney in a normal state versus a diseased state", Prof. Tam shares.
Blocking the carbanoid receptor in the kidney can stop the deterioration
The study found that excess sugar leads to an increased secretion of endogenous cannabis substances in the proximal tubule cells of the kidney, which increases the activity of the mTORC1 protein coupling system. Such a situation increases the entry of sugars into the kidney, which harms its normal function. The research team claims that blocking or lowering the cannabinoid receptor or the glucose pump in the tubular cells in the kidney can significantly prevent the development of the disease. However, in non-diabetic patients the receptor maintains the balance of proteins and amino acids in the cells through tight control. Dr. Hinden emphasizes that blocking the tested cannabinoid receptor or the glucose pump has potential among diabetic patients for effective treatment of diabetic kidney disease. Among non-diabetic patients, one must be careful of using blockers for this receptor, which may lead to a deterioration in renal function. Currently, drugs that block the cannabinoid receptor are in clinical development stages in humans "And thanks to the current research, we will be able to adjust the medical treatment for each patient, diabetic and non-diabetic, thus preventing the development of the disease and the damage it causes", concludes Dr. Hinden.
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