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the cell

Breast cancer cells that express high levels of NUP93 (left) develop fingers that help them move; In contrast, cells without NUP93 are much more stationary (right)

The fight against breast cancer violence

A mouse intestinal mucosa lined with finger-like protrusions (in white) and containing lymphoid organs (in red) that contain germinal centers (in green). Photographed by confocal microscopy

There is no doubling of promotions: the immune system must choose - short term or long term

When the body's defense systems sacrifice the long term for short term victories
The institute's scientists revealed a communication channel between two key players in the cell - the nucleus and the mitochondria - and showed that the two organelles exchange messages with each other through molecular communication lines

Mitochondria answer, it's me

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The institute's scientists revealed a communication channel between two key players in the cell - the nucleus and the mitochondria - and showed that the two organelles exchange messages with each other through molecular communication lines
Immune system cells fight viruses. Illustration: depositphotos.com

The 2022 Wolf Prize in Chemistry promotes the understanding of the chemistry of intercellular communication

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The laureates also worked on inventing chemical methods to study the role of carbohydrates, fats and proteins in these biological processes.
The beginning of life. Illustration - shutterstock

In the beginning there was soap

What was the first chemical entity that met the basic conditions for life?
An MRI scan of a mouse brain shows with the help of two colors the expression of two different proteins. Weizmann Institute

Through the Tissues: The New Life of MRI Scans

If it were possible, for example, to mark with colors the expression of genes in the cells of the body, vital biological processes that are now hidden from view would unfold before our eyes. The fluorescence revolution makes it possible to illuminate, in the full sense of the word, the activity occurring in the cells, but it does not allow observing the processes occurring in the depths of the body
Image of a cell during inflammatory programmed cell death [Courtesy: Principal Investigator]

Scientists have discovered how to slow down and control the process of cell death

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Researchers now have an innovative way to study diseases related to disturbed cell death processes, such as various types of cancer, and acute inflammations in the body, such as 'sepsis', as well as 'acute respiratory distress syndrome' - one of the main causes of death from Corona
Expression of genes indicating the presence of inflammation (marked in brown-red) in intestinal cell samples. A distinct inflammatory presence in the stool samples (left) but not in the biopsy (right)

Without fasting or anesthesia: a non-invasive method for diagnosing inflammatory bowel diseases may replace colonoscopy examinations

Besides the ability to diagnose Crohn's or ulcerative colitis, the new method may allow personalized treatments depending on the nature of the inflammation
A "topographic map" of a segment on the surface of a T cell. The red areas are the flexible fingers described in the paper (the warmer the color, the higher the labeled area). CCR7 receptors (in black) are located at the highest points on the surface of the fingers

Know when to stop

How do the cells of the immune system know how to brake quickly?
The star Wolf-Raya and the nebula that surrounds it as captured by the lens of the Hubble Space Telescope of NASA and the European Space Agency. In the new study, a supernova was observed for the first time in a star of this type // NASA/ESA Hubble Space Telescope

A boom in the middle of the universe: a supernova of a rare type has been discovered

Weizmann Institute scientists have identified a new type of supernova in a galaxy a billion light years away
A mouse embryo with human cells (in green) contributing to its development. These cells were located mainly in the areas of the heart and brain

The cell of all cells - the scientific magic journey - science news, discoveries and information for the public

Prof. Yaacov Hana's method for growing mouse embryos outside the womb was chosen by Science as one of the scientific breakthroughs of 2021. Another study that came out this year from his laboratory advances us a step towards the ability to grow organs for transplantation
A group of zebra fish in an aquarium. Illustration: depositphotos.com

Someone to swim with

How do zebrafish know how to swim in groups?
Fluorescence micrograph of Salmonella bacteria (green) swallowed by macrophage cells (red) originating from the mouse spleen (in blue - the cell nuclei)

The Surprising Players of the Immune System That May Cultivate Bacteria

The new findings may allow the development of new treatments for infections, such as tuberculosis, salmonella and Shigella, and for life-threatening reactions of the immune system
Cultured meat grown in a lab. Illustration: depositphotos.com

Steak in a saucer: a fast track to building muscle fibers

The new findings of researchers at the Weizmann Institute may advance the cultured meat industry
In the growth plate in the tibia of a mouse (left), the cartilage cells grow gradually, from the smallest, at the edge of the bone (in blue), to the largest, closer to the center (in red). In a mouse with a mutation in the Gdf5 gene (right) the gradual growth goes wrong

How we grow: the XNUMXD version

The institute's scientists developed an innovative method for examining hundreds of thousands of cartilage cells in XNUMXD - and with it revealed new information about bone growth
Similar organization of the FIKL cells discovered in the study (left) and pancreatic beta cells (right): the RNA molecules for insulin production (pink-oval) are located closer to the center of the cell, while the insulin molecules themselves (green) accumulate near the cell wall and readiness for discharge

Not in the pancreas alone: ​​insulin-producing cells have been discovered in the fetal intestine

The surprising discovery of scientists from the Weizmann Institute of Science and Yale University opens up new possibilities for the treatment of diabetes
Bacteriophages attack bacteria. Illustration: depositphotos.com

The common fight of bacteria and plants against viruses

A defense mechanism discovered in bacteria may make it possible to improve the resistance of agricultural crops to pests
Cancerous brain tumor. Illustration: depositphotos.com

catch the disease

The institute's scientists located a molecule that irreversibly attaches to a protein that contributes to the development of malignant tumors. Their findings may lead to the creation of a new cancer drug
Photo illustration of the course of the fMRI experiment. During the experiment, an innovative use was made of pressure measuring balls designed to allow the subjects to express aggression in a way that better simulates a natural situation. Photo: Ofer Pearl. Courtesy of Weizmann Institute spokespersons

A body odor molecule common in babies reduces aggression in men and increases it in women

These findings are among the first to directly link human behavior, brain mechanism and smell molecule
blood vessel. Illustration: depositphotos.com

The distribution of attention of blood vessels

The scientists of the institute discovered that the blood vessels "separate" between cell division and branching in new directions. The findings imply that chemotherapy treatments may encourage the growth of blood vessels in the tumor

Opinion: Enzymes are a well-oiled industrial machine

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The analogy to autonomous cars opens up possibilities for continued future research, in which enzymes will be programmed by scientists using methods of artificial intelligence * Article by Prof. Emeritus Sasson Tchaik from the Institute of Chemistry at the Hebrew University
genetic sequencing. Illustration: depositphotos.com

The cell is minimal

Get to know the clustering tiling: knowing more about the minority (the rare cells) with a little help from the majority
Jupiter's Great Red Spot as captured by Juno's camera lens. Its size is the size of the earth

How deep is the most famous spot in the solar system

Scientists from the Weizmann Institute of Science and their partners on NASA's Juno space mission have revealed a series of new findings about the planet Jupiter and found a surprising similarity to Earth
The origin of life from simple molecules to DNA. Illustration: depositphotos.com

to identify patterns in the ancient soup from which life was created

In a new laboratory at the institute, they are examining how basic chemical reactions led to the creation of complex life
Biological clock. Illustration: depositphotos.com

Cell jam session

To what extent are the different biological clocks in our body coordinated with each other?
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