the cell

Protein structure. Illustration: depositphotos.com

This is how molecular machines form tangled proteins

Weizmann Institute of Science research reveals how AAA+ family machines use an energy-efficient mechanism to thread proteins through a tiny channel, providing inspiration for the development of artificial molecular machines

First genetic atlas of the human liver reveals eight areas of activity and vulnerability to fatty liver

Scientists from the Weizmann Institute, Sheba, and Mayo Clinic have mapped the healthy human liver for the first time at a resolution of 2 microns, discovering that the division of functions in it is more complex than in other mammals, explaining why certain areas are sensitive to
Biological glue. Illustration: Dr. Roy Tsezana

Contagious Science: Artificial Intelligence Has Developed an Extremely Strong Medical Glue That Also Works in an Aquatic Environment

New research shows how a combination of natural protein pools and machine learning led to the development of a hydrogel with extraordinary adhesive properties, which may help in medicine and advanced materials in the future.

Not all cold traps at the moon's south pole preserved ice equally well

New scientific evidence suggests that ice has been accumulating on the moon for the past billion and a half years, revealing where it's best to look for it.
Courtesy of Prof. Ariel Monitz

Esophageal alarm protein

Prof. Ariel Monitz's team from Tel Aviv University showed that in allergic esophagitis (EOE) the protein TSLP is active and that its neutralization in an experimental model reduces inflammatory cell infiltration, mucosal thickening, and fibrosis - a hint

Weizmann Institute research: Yeast chooses mates that increase the success of offspring

Mass mating event in the lab reveals how yeast cells choose mates and what predicts the success of offspring
In the graphic summary, from the bottom left corner and clockwise: muscle tissue containing mature cells and blood networks; adipose tissue containing blood vessel and lymph networks; printing of these scaffolds; and immediate feeding of the scaffold by the "host" tissue. Courtesy of Prof. Shulamit Levenberg's laboratory

A first-of-its-kind 3D implant developed at the Technion may dramatically improve treatment of tissue loss

Researchers at the Technion have developed an engineered scaffold containing muscle and fat tissue, a hierarchical blood vessel network, and a lymphatic network, and experiments in rats demonstrated faster and more efficient attachment of the graft to the damaged organ.
Virus-sponge proteins that attack viruses. Illustration: Prof. Rotem Sorek's laboratory, Weizmann Institute

The miracle sponges of phages

A study published in Science shows how viruses attacking bacteria capture or cut immune alarm molecules, using new "sponge" proteins identified by a combination of AlphaFold, artificial intelligence, and experimental biology.
Mitochondria in the cell: not only energy production, but also signals that direct gene expression

When mitochondrial DNA “directs” the immune system

HIV virus. Illustration: depositphotos.com

The microbiome as a hidden protector: Gut bacteria partially compensate for HIV damage to the intestinal mucosa

A new study conducted in Israel and Ethiopia, led by researchers from the Weizmann Institute and Hadassah, reveals that the microbiome partially compensates for the damage that HIV causes to immune system cells in the intestinal mucosa and may lead to treatment directions.
Increasing life expectancy. Illustration: depositphotos.com

Life expectancy is more hereditary than we thought: Study in Science suggests about 50% genetic influence

New mathematical model and analysis of twin databases from Sweden, Denmark and the US separate “external” mortality from aging – doubling previous estimates
Satellite image of a winter storm in the American northwest. Source: CIRA

Pacific winter storm track moving north faster than forecast

Shifting storm tracks due to climate change is warming and drying out large areas of the American Northwest.
DARE cells (their bodies are marked in green) and NARE cells (their bodies are not marked) in the epithelial tissue from which the fly wing develops. In red – the nuclei of the cells as they divide. The scientists discovered that NARE cells receive signals from neighboring DARE cells that tell them to divide

Resurrected tissues

The ticking of the biological clock in a human cell throughout the day. A fluorescent marker allows scientists to see "what time is it" at any point in time

New study reveals key role of sex hormones in our biological clock

The findings may shed new light on disruptions in the biological clock during menstruation, pregnancy, and menopause.
Dr. Ohad Waneshk and the biochip. Photo: Weizmann Institute Spokesperson

The biochip that is already ready for the next pandemic

A new DNA chip from the Weizmann Institute of Science produces dozens of viral antigens on silicon in a single experiment and rapidly maps the immune “fingerprint” of subjects – a tool that could accelerate the development of tests, vaccines,
Human lung cancer tissue under the microscope. The helper macrophages (in red) are surrounded by enzymes (in yellow) that activate the stimulating part of the antibodies they develop. This targeted action prevents damage to healthy tissue.

Neutralize the defense, go on the offensive: Smart antibodies to fight cancer

Researchers from the Weizmann Institute of Science have identified immunosuppressive macrophages in tumors and developed smart molecules called MiTEs that target the TREM2 receptor and locally activate IL-2 – with the aim of overcoming resistance to immunotherapy without causing side effects.
cultured meat. Illustration: depositphotos.com

Beef cells can become immortal without genetic engineering: A breakthrough towards cultured meat

Hebrew University and Believer Meats team shows spontaneous cell renewal in bovine cultures without signs of malignancy, with telomerase and PGC1α activation; potential for stable cell lines and scale-up production
Created in BioRender. Lab, R. (2025) https://BioRender.com/flbu8cx

Research conducted at the Faculty of Biology at the Technion reveals a unique mechanism in the aging of the immune system

In an article in the prestigious journal Nature Aging, researchers present a blueprint for improving the effectiveness of the immune system in old age.

Man accelerates, nature declines: Two studies shed new light on 170 years of intensifying human activity

If we quantify the extent of human movement on Earth, we find that we move 40 times more than all land animals combined; if we look at the timeline, we see that while the weight of farm animals has skyrocketed
A brain that runs away from losses. Illustration: depositphotos.com

Brain runs away from loss: This is how the brain makes adventurous decisions to avoid losses

Weizmann Institute and Ichilov Institute study reveals, using electrodes deep in the brain, how loss avoidance mechanisms affect learning, memory, and anxiety and post-traumatic stress disorders
The developing brain of a two-week-old mouse pup under the microscope. The oxytocin system is highlighted in green and a light-sensitive protein is highlighted in red. The combination of colors causes the oxytocin cells that also successfully express the protein to be colored yellow. In blue - the cell nuclei

Spotlight on the developing brain: Separation in early childhood alters the oxytocin system

Weizmann Institute of Science scientists have developed a new optogenetic technology that allows them to study the activity of the oxytocin system deep in the young brain. Their findings show that this protein, known as the "love hormone," influences the coping of mouse pups.
Five-day-old zebrafish embryos under a microscope: the normal embryo (top) and the transgenic embryo (bottom) carrying the gene with the disease-causing mutation. It can be seen that in the transgenic embryo the main lymphatic vessel is abnormally enlarged

From the clinic to the aquarium: New zebrafish-based drugs for a rare lymphatic disease

A unique collaboration between the Weizmann Institute of Science and Sheba Medical Center led to the discovery of two potential drugs for a life-threatening disease of the lymphatic system.
From right: Dr. Naama Darzi, Prof. Ayelet Erez, Dr. Natalie Rosenfeld and Dr. Elizaveta Bab-Dinitz. Photo by Weizmann Institute Spokesperson

It's all in the head: Blocking the communication channel between the brain and liver may prevent life-threatening weight loss in cancer patients

Research at the Weizmann Institute of Science demonstrates how communication between the brain and the body's organs plays a critical role in health and disease
Diagram of the structure of mitochondria. Illustration: depositphotos.com

When the cell's energy station goes wrong

Researchers from the Hebrew University have identified a neural network that works against the feeling of reward – and offer a new therapeutic approach to dealing with drug addiction by regulating emotional pain during withdrawal.
Overexpression of B2-SINE family genes in retinal ganglion cells (top) led to accelerated growth after injury. Below: Ganglion cells after injury without overexpression of B2-SINE

Weizmann scientists discovered hundreds of molecules that accelerate nerve regeneration – including in the brain

The study, published in the journal Cell, reveals a new role for rare RNA molecules that help peripheral nerves and even encourage the regrowth of nerve cells in the brain. A breakthrough in the treatment of degenerative diseases and rehabilitation from injuries
Human fat cells. Illustration: depositphotos.com

The Fat Sense: How the Nervous System Affects Metabolism and Obesity

Weizmann Institute researchers have found that nerve cells sense mechanical changes in fat tissue and regulate the body's energy burning. Suppressing this mechanism makes mice immune to obesity and diabetes
Tolerance Patrol: Mouse lymph tissue with a cluster of immune system cells (marked in green, red, and blue) that communicate with each other and lead to food tolerance

The immune system knows when not to fight — and thus prevents food allergies

Weizmann Institute of Science scientists reveal how the immune system allows us to eat whatever we want, without developing an allergy or disease.
Various modern concrete objects with dramatic lighting on a dark background.

MRI with one nanometer resolution

Weizmann Institute scientists have developed a nano-MRI method that allows imaging of single molecules at room temperature
A ubiquitin molecule binds to its target. Illustration: depositphotos.com

The protein that is (sometimes) to blame for Alzheimer's disease

A distorted version of a protein that marks damaged proteins causes the formation of deposits in the brain similar to what occurs in Alzheimer's disease
"The results suggest that whiskers are an integrative and multisensory sensory system. It may have evolved this way throughout evolution to help mice locate food or protect themselves from predators." Illustration: depositphotos.com

The whisker that hears: Mice identify objects by the sounds their whiskers make

New research from the Weizmann Institute presents a fascinating turn in sensory research – mice whiskers not only sense touch, but also produce sounds that are captured by the auditory system and used to identify objects.
Broken glass on a black background, intricate cracks, beauty in destruction and the fragility of glass.

How internal disorder dictates asymmetric refraction

Weizmann Institute of Science scientists have uncovered laws of physics that explain why cracks in a material propagate asymmetrically, laying the foundation for developing more durable materials.

Get rid of the fat and lose weight

Weizmann Institute of Science scientists reveal how the mitochondrial protein Mitch affects obesity and muscle endurance, potentially paving the way for an improved weight loss drug that doesn't have the drawbacks of Ozempic

Language beyond words

Weizmann Institute of Science scientists have revealed that the melody of English speech behaves like a language with vocabulary and syntax, paving the way for artificial intelligence to understand it.
Women support breast cancer awareness using the pink ribbon symbol. Illustration: depositphotos.com

To put the cancer to sleep

Weizmann Institute of Science scientists reveal how breast cancer cells enter dormancy, how it is maintained over years – and why they suddenly awaken and form metastases
DNA. Illustration: depositphotos.com

The genetic switch that brings immune cells back into battle

In Prof. Ido Amit's laboratory at the Weizmann Institute of Science, they identified a gene whose silencing reprograms immune system cells and can transform them from cancer supporters to cancer killers.
Infographic: Macedo Veiga Junior (Valve)

The body as a roadmap: New algorithm unlocks the secrets of our proteins

An illegible microscopy image with overlapping fluorescent labels of seven proteins (left) was translated with great precision using CombPlex into an image that allows the different proteins to be distinguished (right)

All embroidery colors

AI-based technology developed in Dr. Liat Keren's lab enables an unprecedented view of processes in body tissues

A new direction for fighting cancer: making it incriminate itself

Prof. Yardena Samuels' lab at the Weizmann Institute of Science has succeeded in making cancer cells surrender themselves to the immune system. The new approach may offer hope to incurable patients

They will die and not learn: The lesson that male worms refuse to internalize

In Dr. Meital Oren-Suisa's lab at the Weizmann Institute, they discovered that male worms learn less well from experience compared to females, and uncovered a neural receptor that is responsible for the difference between the sexes and is also conserved in humans.

New immune mechanism discovered in the cellular trash can

In the laboratory of Prof. Yifat Marbel at the Weizmann Institute of Science, a vast reservoir of antimicrobial substances was discovered that are naturally produced in the body's cells as part of the process of breaking down proteins that have completed their function. The new discovery is
A microscopic image of tissue stained in purple, red, and green to identify various cellular components.

Two ways to a broken heart, two ways to heal

Pull the protein tail

Thousands of proteins depend on their tails to locate themselves in cell membranes and carry out their essential functions. Changes in the tails can lead to rare genetic diseases
chromatin structure. Illustration: depositphotos.com

How proteins and DNA shape cell identity

New research reveals a fascinating mechanism of "guided search," in which DNA and chromatin structure act as a "road map," directing proteins to specific genetic targets. The mechanism provides new insights into the acquisition of cellular identity that may promote
Heart attacks happen at night. The image was prepared using DALEE and should not be considered a scientific image.

Why do more heart attacks and asthma occur at night?

Weizmann Institute of Science scientists have discovered why the small hours of the night may be prone to disaster
3D imaging of protein structure in the bitter taste gland. Figure courtesy of the researchers

A hidden pocket in the bitter taste receptor has been discovered in the human body

The research shows that the TAS2R receptors are involved in many processes such as breathing, digestion and the immune system. "The opposite sense of taste: an unusual sensory mechanism discovered in the detection of bitter taste in humans"