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the cell

Two fruit bats in Australia. Photo: depositphotos.com

When neurons change gears: how the brain copes with sudden changes

New research done in bats reveals far-reaching dynamic capabilities of neural networks
Coca Cola Zero. Image: depositphotos.com

Without calories but not without a price: how sugar substitutes affect the human body

Institute scientists have shown that calorie-free sweeteners affect the composition and activity of intestinal bacteria and may disrupt the body's metabolism; The degree of influence varies greatly from person to person
Illustration of organ transplantation and cell retrieval with OrganEx technology. The blood equivalent that maintains the cells is brought to vital organs an hour after death. Credit: Marin Balaic

Cheating death: Mail scientists restore cell and organ function in pigs after death

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Technology developed at Yale University restores the function of cells and organs in pigs after death, a potential breakthrough in organ transplantation.
Bacteriophages attack bacteria. Image: depositphotos.com

An innovative therapeutic approach mobilizes viruses to intercept disease-causing gut bacteria

In a study published today in the scientific journal Cell, Weizmann Institute of Science scientists demonstrated an innovative therapeutic approach that performs "targeted defeat" of unwanted intestinal bacteria using a creative and precise weapon - viruses that attack bacteria
Image: depositphotos.com

RNA 90210

On the genetic equivalent of postal targeting - and on the decisive differences between linear and circular molecules
Embryonic stem cells. Image: depositphotos.com

The superpower of a newborn fetus

How can cells be returned to their initial and most powerful state?
An AIRE-ILC3 cell (in green) kisses a TH17 cell (in red) and thus commands it to proliferate (top row). In contrast, it does not bind to other T cells that are not designed to fight candida (bottom line)

The cells that prevent candida from returning

Weizmann Institute of Science scientists have uncovered a mechanism of the immune system that helps fight Candida infections
The electronic nose used by the researchers. Smells potential for brave friendships

Humans tend to make friends with those who have a similar body odor to their own

This is according to a new study by Weizmann Institute scientists. Moreover, the scientists were able to predict in the study what the degree of connection between complete strangers would be just on the basis of their smell as picked up by an "electronic nose"
How ketamine works: a schematic diagram of the new mechanism discovered in the study alongside the known mechanism. Ketamine molecule directly inhibits a certain type of receptors for the neurotransmitter glutamate (top left) and produces a chain reaction that leads to increased expression of potassium ion channels (KCNQ) in neurons of the glutamate system in the anterior hippocampus (right)

Crossing the canal: how does today's most promising molecule for the treatment of depression work?

Using advanced methods for genetic sequencing at the single cell level, Weizmann Institute of Science scientists reveal a new molecular mechanism of action of ketamine - and show that combining it with another drug may lead to improved performance and reduced side effects
Cells that produce bone tissue (in red) and lymphatic vessels (in green) in a developing fin of a young zebrafish

Blood relationship

How are blood vessels born? The institute's scientists revealed surprising findings following observations of the fins of young zebrafish
Prof. Michael Sela, 2016. Photo: Yael Ilan

Prof. Michael Sela, former president of the Weizmann Institute, one of the developers of Copaxone and other drugs, has passed away.

From childhood in a factory yard in Poland to the top of world science and the development of best-selling drugs that have helped millions around the world
Winter storms in the Southern Hemisphere / NASA Worldview

Warning storms: the truth data reveals - the climate crisis is progressing faster than expected

A new study led by Weizmann Institute of Science scientists reveals that the intensification of winter storms in the Southern Hemisphere has already reached the level of predictions for the end of the 21st century
Schematic diagram of the pyruvate dehydrogenase (PDC) protein complex. Responsible for the transition between the metabolic pathways for the breakdown of sucralose and the production of energy in the mitochondrion ("Krebs cycle"). On the left: the classic move as it was known until now with the addition of the research hypothesis (marked with a question mark), on the right: the move as observed in transgenic mice without enzymes from the PDK family. The backup plan revealed in the study is highlighted with an exclamation mark

Opening a circle

Institute scientists are updating a version of one of the most classic diagrams in biochemistry books - the Krebs circle
Schematic diagram of the bacterial operon (top) versus the eukaryotic transferron (bottom). According to the researchers, instead of "beads on a string" a kind of genetic "stroke-na" game developed during evolution that allows using the same "letters" - that is, messenger RNA molecules originating from genes located on different chromosomes - to create different "words", i.e. different transferrons

make from an elephant bacterium

How did evolution overcome the lack of order in the storage of genetic information in the transition from bacteria to more developed creatures?
genetic editing. Photo: depositphotos.com

protect the cell from the immune system

Between the genetic editing mechanism of RNA and the evolution of DNA
Prof. Yosef Shaul. The virus ignited his imagination

FDA approval for a third generation vaccine for viral hepatitis B

The component was developed based on the research of Prof. Yosef Shaul
Spirulina. Illustration: depositphotos.com

Breakfast of champions

When did unicellular algae become so nutritious - and how the change paved the way for an evolutionary leap
XNUMXD structure of an enzyme from the versatile peroxidase family generated through artificial intelligence-based prediction. The yellow dots mark mutations introduced by the algorithm developed in Prof. Fleishman's laboratory, with the aim of increasing the stability of the enzyme

The proteins of the future are already here

A combination of artificial intelligence and protein design algorithms allows for the first time access to a gold mine: millions of natural proteins that can be used in a variety of environmental, medical and industrial applications
In healthy skin tissue samples (left) ScAF cells show thin and elongated "tails" (in green), while in patients with limited scleroderma (center) - and even more so in patients with diffuse scleroderma (right) - there are fewer and fewer ScAF cells, and those that remain gradually lose their Their elongated tails show different expression levels of some proteins (marked in blue and red)

In a new skin: transforming every cell on the way to understanding a rare autoimmune disease

Weizmann Institute of Science scientists in collaboration with Hadassah and Rambam doctors present a new road map for the study of diseases in which there is still much that is hidden on the open
Microglial cells that were "ripened" in the laboratory from stem cells derived from ALS patients (in green), the cell nuclei - in blue. Photographed using a confocal microscope

The good mutation

Weizmann Institute of Science scientists have discovered a new pathway that may protect nerve cells in the brain and slow down the development of degenerative brain disease
A new study sheds light on an important mechanism in the degradation of white blood cells. Illustration: Maya Factor, courtesy of Tel Aviv University

A new study sheds light on an important mechanism in the degradation of white blood cells

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Natural cancer antibodies (green) bind to ovarian cancer cells. Cell nuclei in blue. Photographed using a confocal microscope

The new players in the war on cancer

Our immune system has a powerful and accurate weapon to destroy bacteria and viruses. It is possible that in the future it will also be possible to harness it against malignant tumors
The Fantastic Five: strontium ions in a vacuum chamber trapped in an array of electric fields and cooled using laser beams to a temperature several millionths of a degree above absolute zero

Israel enters the quantum computing club

Weizmann Institute of Science scientists present the first Israeli quantum computer; In its construction, innovative methods were applied that will help advance the field towards unprecedented computational capabilities
How the body packs 2 meters of DNA into a tiny cell nucleus. Courtesy of Tel Aviv University

How does the human body pack 2 meters of DNA into a tiny nucleus that is only a few thousandths of a millimeter in size

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Since the genes are found along the length of the DNA, then the staggered way in which the DNA is arranged inside the nucleus separates the genes according to the content of their building blocks and thus the DNA is actually packed inside the tiny nucleus
Antibodies attack the corona virus. Illustration: depositphotos.com

Not all antibodies are created equal

Critically ill, recovering or vaccinated - how do the antibodies to corona that each of the groups produces differ and what are the unique characteristics of the antibodies acquired following vaccination
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