* 11 awards for innovative developments will be awarded next week at the session of the Board of Trustees of the Hebrew University
Above: The open film. Below on the right is a gelatin capsule containing a multi-layer film containing the drug and on the left the preparation after 8 hours in the stomach of dogs
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The progress made in recent years in drug delivery technologies has not yet provided a solution for the delayed and controlled release of a wide variety of drugs whose absorption is limited to the upper part of the digestive system (small intestine). After ingestion, these drugs pass relatively quickly through the absorption site and it is not possible to obtain a prolonged and controlled absorption for them, which allows the reduction of the number of daily doses of the drug.
Researchers at the School of Pharmacy at the Hebrew University have developed a new technology to prolong the absorption of these drugs. This is a system based on a multi-layer film containing the drug.
The film is folded and stored inside a standard gelatin capsule and after swallowing it, the gelatin melts and the preparation opens to its initial dimensions. Thanks to the mechanical properties of the preparation and its dimensions, it stays in the stomach for several hours. At the same time, the drug is released in the stomach, over time and continuously, and its prolonged absorption from the intestine into the blood is possible, and accordingly the duration of the drug's activity in the body is extended.
The new technology can be used to carry various active substances with a variety of physicochemical properties in large quantities (up to 400 mg); It is of particular importance for various drugs that have absorption problems and in which maintaining a stable level of drug concentration in the body is critical - including drugs for the treatment of immunodeficiency (AIDS) as well as disorders of the heart and blood vessels and of the central nervous system. The new method also minimizes side effects (which result from high concentrations of the drug) and reduces the frequency of drug treatment.
For their research into the development of the new technology, Prof. Amnon Hoffman and Prof. Michael Friedman from the School of Pharmacy at the Hebrew University and Dr. Eran Lavie from the Kurt University School of Veterinary Medicine will receive the Kay Award for Innovative Developments.
The Hebrew University's R&D implementation company has registered a patent for the method and the first steps towards commercial development are being taken these days with the start-up company "Intech-Pharm" in Mount Hahotsavim in Jerusalem.
The eleventh annual Kay Awards ceremony will be held on Tuesday, June 08, 2004, at 10:00 am, in the Independence-Mexico Hall, the Hebrew University of Jerusalem, Kiryat Har Ha Scopus. The ceremony takes place as part of the 67th session of the Board of Trustees of the Hebrew University of Jerusalem.
The Kay Award ceremony for innovative developments has been held at the Hebrew University every year since 1994. Yitzhak Kay from England, a prominent industrialist in the pharmaceutical industry, founded the practice of awarding awards to encourage university faculty and students to develop innovative methods with commercial potential that will benefit the university and society.
They knew innovations in medicine
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