This is a natural substance that is injected into the brain and develops immunity to the drug in those who are weaned • Researchers Dr. Gal Yadid, Dr. Rachel Ma'ain and Prof. Avraham Weizman completed the research in rats and about two weeks ago the treatment in humans began at a rehab center • If it succeeds to the same extent, it will be a global breakthrough • At the conference where it will be shown for the first time
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A research breakthrough in the field of drug rehab emerges from a new study at Bar Ilan University. This is a natural substance that is injected into the brain and develops immunity to the drug in those who are weaned. The research will be presented for the first time at an international conference at the Multidisciplinary Center for Brain Research in Moshav on the topic "Drugs: effects on brain function, addiction and treatment" Thursday, June 17, 2004.
"Today there is no treatment for drug addiction, maybe our research will lead to a breakthrough" says Dr. Gal Yadid, head of the neuropharmacology unit at Bar Ilan University. "In the attempts to detox from drugs that are accepted in the world today, the addicts simply become addicted to a replacement substance given to them, and remain a broken vessel." Dr. Gal Yadid, who heads the chair for research on addiction and control of emotional expression, has devoted the last two years to research on the subject. "In today's rehab attempts, the addict receives a drug, a substance called methadone, which blocks receptors in the brain that cause a feeling of pleasure. The blockage is supposed to prevent the enjoyment of the drug and the craving for it.
The concept is that without pleasure - a person will stop consuming the drug and eventually quit," says Dr. Yadid, "There is a big problem with this method: the critical phase of returning to the drug is the first month in the detoxification process, and the systems in the body are so stimulated that the addict is unable to restrain the His longing for the drug. Most cases of the addicts dropping out and retiring from the process occur at this stage. A person who consumes a drug at this stage will not enjoy it, but the brain "remembers" the drug and one exposure to the drug after a long withdrawal, returns it to regular consumption. And his rehab attempt was simply erased as if it hadn't happened."
The conceptual breakthrough of Dr. Gal Yadid version is exactly the opposite: the controlled replacement of the drug with a substance that will cause a similar stimulus will reduce the need for the drug. Instead of blocking the pleasure, encourage it. Instead of withholding material from the body, add more, flood it. The substance, DHEA, a steroid produced in the brain, is used in the US as a food additive, and during treatment is injected into the brain. Adding the substance in increased doses causes the brain to defend itself from the excess, return to a normal level of receptors, and the body no longer reaches such a high level of excitement. A person who goes through the process of injecting the substance, after which he consumes a dose of a drug, will react to it similarly to the first time he consumed a drug. "The body simply develops an immune system," says a friend, "it is immune to the drug, and that tremendous crash, the immediate return to the drug that exists in the detoxification process known today, simply does not exist."
The results of the experiments in the laboratory were more successful than expected, and following the promising results, the researchers began about two weeks ago similar treatment for addicts at the Jaffa rehab center under the management of Dr. Issachar Herman. If the experiment succeeds to the same degree as its success in the laboratories, then it is a global breakthrough.
The study, conducted with the support of the Anti-Drug Authority, began in Israel and brought together three expert researchers: Dr. Gal Yadid - Head of the Neuropharmacology Unit and Head of the Chair for Research on Addiction and Control of Emotional Expression at Bar Ilan University. Dr. Rachel Maayan - Felzenstein Institute, at the Beilinson Medical Center, an expert in neurosteroid research and Prof. Avraham Weizman - a veteran doctor and researcher from the "Gaha" Medical Center.
They knew innovations in medicine
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