Bar Ilan University: A research breakthrough in the field of drug rehab

This is a natural substance that is injected into the brain and develops immunity to the drug in those who are weaned • Researchers Dr. Gal Yadid, Dr. Rachel Ma'ain and Prof. Avraham Weizman completed the research in rats and about two weeks ago the treatment in humans began in a rehab center • If it succeeds to the same extent, it will be a global breakthrough • At the conference where it will be shown for the first time

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A research breakthrough in the field of drug rehab emerges from a new study at Bar Ilan University. This is a natural substance that is injected into the brain and develops immunity to the drug in those who are weaned. The research will be presented for the first time at an international conference at the Multidisciplinary Brain Research Center in Moshav on "Drugs: Effects on Brain Function, Addiction and Treatment" Thursday, June 17, 2004.
"Today there is no treatment for drug addiction, perhaps our research will lead to a breakthrough," says Dr. Gal Yadid, head of the neuropharmacology unit at Bar Ilan University. "In the attempts to detoxify drugs that are accepted in the world today, addicts simply become addicted to a replacement substance given to them, and remain a wreck." Rabbi Gal Yadid, who heads the chair for research on addiction and control of emotional expression, has devoted the last two years to research on the subject. "In today's rehab attempts, the addict receives a drug, a substance called methadone, which blocks receptors in the brain that cause a feeling of pleasure. The blocking is supposed to prevent the pleasure from the drug and the craving for it.
The concept is that without pleasure - a person will stop consuming the drug and eventually quit," says Dr. Yadid, "There is a big problem with this method: the critical phase of returning to the drug is the first month in the detoxification process, and the body's systems are so stimulated that the addict is unable to restrain the Craving for the drug. Most of the addicts drop out and withdraw from the process. A person who consumes a drug at this stage will not enjoy it, but the brain "remembers" the drug and exposure One drug after a long withdrawal, returns him to regular consumption, and his withdrawal attempt is simply erased as if it had not happened."
Dr. Gal Yadid's conceptual breakthrough version is exactly the opposite: the controlled replacement of the drug with a substance that will cause a similar stimulation will reduce the need for the drug. Instead of blocking the pleasure, encourage it. Instead of withholding a substance from the body, add more, flood it. The substance, DHEA, A steroid that is produced in the brain, is used in the US as a food additive, and during treatment is injected into the brain. Adding the substance in increased doses causes the brain to defend itself from the excess, return to a normal level of receptors, and the body no longer reaches such a high level of excitement. A person who goes through the process of injecting the substance, and then consumes a dose of a drug, will react to it similarly to the first time he consumed a drug. "The body simply develops an immune system," says a friend, "it is immune to the drug, and that tremendous crash, the immediate return to the drug that exists in the detoxification process known today, simply does not exist."
The results of the experiments in the laboratory were more successful than expected, and following the promising results, the researchers began about two weeks ago similar treatment for addicts at the Jaffa rehab center under the management of Dr. Issachar Herman. If the experiment succeeds to the same degree as its success in the laboratories, then it is a global breakthrough.
The study, conducted with the support of the Anti-Drug Authority, began in Israel and brought together three expert researchers: Dr. Gal Yadid - Head of the Neuropharmacology Unit and Head of the Chair for Research on Addiction and Control of Emotional Expression at Bar Ilan University. Dr. Rachel Maayan - Felzenstein Institute, at the Beilinson Medical Center, an expert in neurosteroid research and Prof. Avraham Weizman - a veteran doctor and researcher from the "Gaha" Medical Center.
They knew innovations in medicine

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