The scientists of the institute hypothesized that the location of non-coding genes might teach about their function. The scientists showed that the non-coding gene "Chaser" regulates the coding gene next to it, which was previously linked to epilepsy and autism
Just knowing where a person spends his time can teach a lot about him. Researchers at the Weizmann Institute of Science used this idea to study a certain part of the human genome - genes that do not code for proteins but are transcribed into control molecules, called long non-coding RNA molecules (lncRNA for short). Very little is known about the role of these thousands of segments scattered throughout the human genome, but the institute's scientists hypothesized that their location could provide a clue: since the lncRNAs tend to be found in DNA regions involved in the control of protein production, the researchers hypothesized that they also play a role Supervised this manufacturing plant.
In a study recently published in the scientific journal Nature Communications, Dr. Igor Olitsky and his group members in the Department of Biological Control focused on the lncRNA gene, which they named Chaserr. The researchers assumed that this gene plays an important role in the genome, as it has been preserved during evolution from fish to humans. Chaser is located in the genome near the beginning of another gene - Chd2, which participates in the control of protein production. Mutations in Chd2 have previously been linked to epilepsy and autism. Due to the physical proximity between the two genes, the researchers hypothesized that Chaser constitutes another control layer, in addition to Chd2, which regulates, among other things, processes necessary for normal neurological function.
In order to find out what the function of Chaser is, Dr. Olitsky and his colleagues created transgenic mice without this gene, and discovered that they die shortly after birth or do not develop properly - a fact that indicates that Chaser's role in the genome is indeed essential. Additional studies have shown that without a chaser the expression of Chd2 clearly increases. In other words, Chaser apparently suppresses Chd2, making sure that this gene produces protein at adequate levels.
In some people with epilepsy and autism, insufficient activity of the Chd2 gene has been identified. This research may one day produce a solution in the form of a small molecule that blocks the chaser, loosens its grip on the Chd2 gene and boosts its expression to normal levels"
Additional studies have shown that too high levels of the protein produced by Chd2 cause problems in mouse embryos. "When Chd2 is excessively active, the excessive amounts of the protein it produces probably cause a sort of traffic jam at the junctions between the genes, thereby disrupting the production of proteins in hundreds of different places in the genome," says Dr. Olitsky. These "traffic jams" also hint at how Chaser works: the gene probably participates in a feedback mechanism that regulates the expression of Chd2 by creating a traffic jam near it, when its protein level increases excessively.
But insufficient expression of Chd2 is no less problematic than its excess expression. In fact, insufficient expression is precisely the genetic defect identified in people with epilepsy and autism. The mutation has indeed been identified in a small proportion of people with these syndromes, but for those whose problem is indeed due to insufficient activity of the Chd2 gene, this research may one day produce a solution in the form of a small molecule that blocks Chaser and thereby releases its hold on the Chd2 gene, jumps the Its expression reaches normal levels and corrects the genetic defect.
The research group included Aviv Rom, Lilia Melamed, Naa Gil, Micah Goldreich and Dr. Rotam Ben-Tov Perry from the Department of Biological Control, Matan Golan from the Department of Molecular Cell Biology and Dr. Inbal Biton from the Department of Veterinary Resources - all from the Weizmann Institute of Science, and Dr. R. Rotem Kadir from Ben-Gurion University in the Negev.
Similar to Chaser, there are about 100 genes for long non-coding RNA molecules conserved among the different vertebrate species - from humans to fish.
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Beyond the hashing of the writer's words.. just two points.. the first: who told you?.. all the prophets laugh at me in their own name.. as if they have a direct connection with the Creator.. and they tell stories.. as if they have a mission on behalf of someone. Even rabbis and other self-proclaimed charlatans have this superior quality - I wonder who explained it to them and in which media channel.
The second point.. really simple.. if he and others like him had devoted a few hours to studying the theory of evolution and the laws of natural selection they would have realized that there is simply no need for that sublime power and there is a scientific explanation.. and surprisingly even quite simple that explains the whole development and how we got to our current form which is wonderfully suited to our environment... and that we left behind all those that did not fit the environment, such as the dinosaurs, for example. So I know.. it's hopeless.. and a waste of time.. but still.. for the benefit of those who think and hesitate.. God is simply not needed to explain almost any phenomenon... those who want to believe.. please.. I respect.. but enough With the pretense of understanding or passing messages on his behalf.. they just don't need him anymore.. the process is generally understandable.. and the last building blocks are falling into place.
Is this what Prostitotska in Tel Baruch thinks? ?
In light of all the plans and discoveries of science, which is just beginning to dig in the gardens and in the gardens and in the gardens and wells, you have not yet received the token that these are not coincidences, things are being implemented so much, and this biological nanotechnology is being implemented at the levels of violent engineering, not nature, and nonsense. A day will come and you will discover what it is said that God created us in his image, what is enough there is no island of his and that is why we investigate and in the end you will come to the predicament that I have come to since time due to signs and knowledge like a riddle that God left that God is the creator and these are the signs that I learned in life from the Tanach and the holy books and let there be light? The Big Bang Resurrection? DNA replication and consciousness recording projects? Did they not know about these things thousands of years ago? Can God be everywhere all the time? Quantum entanglement? A strange cough from a distance has no scientific explanation, but the communication is instantaneous everywhere without a limit, a distance of a billion light years or a kilometer? Evidences of angels in creation and ascensions to heaven in chariots of fire (Elijah the prophet) and more? God acts with words and there will be light and the earth will open its mouth and blow its nose. All of these point to technologies like the remote control. We don't understand them, but we already know today that devices can be operated with commands to spacecraft and satellites, similar to light commands from a keyboard and remote controls for activity from a distance of hundreds of millions of kilometers and even from a distance of light years? Creation of the universe And the birth of the primordial generation, followed by the second generation of the Kubites, and the knowledge that stands behind the creation of generation XNUMX and generation XNUMX and the creation of planets and then life, all of which is made from a primordial light explosion whose outcome is known in advance to the Creator, indicating that the Creator creates universes and fills the darkness with light and life, he simply sows universes teeming with life And the marble of its diameter is the sound, there is no island, and the genome that they are intertwined in the light of the bang, all the seeds of life are the big plan, what's next, wait a billion years?