Weizmann Institute

Researchers in the lab simulate the evolution of the coronavirus to identify dangerous variants

A fast-moving pandemic: Researchers simulated an entire pandemic in the lab – and predicted how a dangerous variant might emerge

Scientists from the Weizmann Institute and Charles University in Prague have succeeded in simulating in the laboratory, within months, an evolutionary trajectory that resembles the development of the coronavirus throughout an entire pandemic. The research may help in the early identification of dangerous variants and in preparing for pandemics.

Immune system memory cells may help in long-term fight against ovarian cancer

A study from the Weizmann Institute of Science reveals that memory cells of the immune system do not only work against viruses and bacteria. In women with ovarian cancer, memory B cells were found that are able to reach the tumor and produce antibodies.
Iron-rich rock in the Lake Mead area in the USA. Illustration: depositphotos.com

Israeli research offers a solution to the mystery of life's directionality

New research from the Weizmann Institute and the Hebrew University of Jerusalem offers a solution to a 150-year-old mystery: why the molecules of life chose one orientation. The researchers found that chiral molecules that appear as mirror images respond differently when

Stem cells in the gut sacrifice themselves to stop bacterial infection

A study by the Weizmann Institute and the Hebrew University reveals a new immune defense mechanism: stem cells infected with Salmonella accelerate their maturation, stop reproducing, and help save intestinal tissue.
Protein structure. Illustration: depositphotos.com

This is how molecular machines form tangled proteins

Weizmann Institute of Science research reveals how AAA+ family machines use an energy-efficient mechanism to thread proteins through a tiny channel, providing inspiration for the development of artificial molecular machines

First genetic atlas of the human liver reveals eight areas of activity and vulnerability to fatty liver

Scientists from the Weizmann Institute, Sheba, and Mayo Clinic have mapped the healthy human liver for the first time at a resolution of 2 microns, discovering that the division of functions in it is more complex than in other mammals, explaining why certain areas are sensitive to

Not all cold traps at the moon's south pole preserved ice equally well

New scientific evidence suggests that ice has been accumulating on the moon for the past billion and a half years, revealing where it's best to look for it.

Ants that build in the tops: This is how one colony solves complex problems with living tools

Research by the Weizmann Institute of Science shows that weaver ants connect their bodies into zipper-like chains and weights, build stable nests on treetops, and may even demonstrate advanced group cognition.

Weizmann Institute research: Yeast chooses mates that increase the success of offspring

Mass mating event in the lab reveals how yeast cells choose mates and what predicts the success of offspring
Virus-sponge proteins that attack viruses. Illustration: Prof. Rotem Sorek's laboratory, Weizmann Institute

The miracle sponges of phages

A study published in Science shows how viruses attacking bacteria capture or cut immune alarm molecules, using new "sponge" proteins identified by a combination of AlphaFold, artificial intelligence, and experimental biology.
Distracting red color: Parasitic RNA molecules (red dots) that managed to penetrate cell nuclei (blue) of monocytes (green)

The secrets of the malaria parasite's nucleus: How the parasite penetrates the command center of immune cells

A study by Weizmann Institute of Science scientists reveals that the malaria parasite sends RNA molecules to the nucleus of immune system cells, disrupting their splicing mechanism and diverting the body's defense response from its target.
HIV virus. Illustration: depositphotos.com

The microbiome as a hidden protector: Gut bacteria partially compensate for HIV damage to the intestinal mucosa

A new study conducted in Israel and Ethiopia, led by researchers from the Weizmann Institute and Hadassah, reveals that the microbiome partially compensates for the damage that HIV causes to immune system cells in the intestinal mucosa and may lead to treatment directions.
Alzheimer's. Illustration: depositphotos.com

From cancer to Alzheimer's: Engineered immune cells reduce protein deposits in the brain

In a study published in PNAS, T cells were engineered to recognize amyloid proteins in the brain; the injections reduced the extent of deposits and markers of brain inflammation—offering a new direction for degenerative brain diseases
Increasing life expectancy. Illustration: depositphotos.com

Life expectancy is more hereditary than we thought: Study in Science suggests about 50% genetic influence

New mathematical model and analysis of twin databases from Sweden, the United States and the United Kingdom separate “external” mortality from aging – and double previous estimates
Passing “behind” Jupiter: Blocking and bending the radio signal allows for a more precise measurement of the planet’s shape.

New measurements shrink Jupiter: The giant planet is smaller and flatter than we thought

Analysis of 26 radio measurements from the Juno mission, when the spacecraft passed behind Jupiter, found that the planet is about 8 km narrow at the equator and about 24 km flat at the poles – a change that refines models of the internal structure and winds.
Five whisker follicles in a 100-micron-thick piece of tissue. Each follicle is surrounded by a thick collagen capsule and contains hundreds of mechanoreceptors, some of which have tuft-like tips. These unique external touch sensors are located near the follicle's center of mass (center of image), anchored to a collagen ring (an open C-shaped ring) that acts as a stabilizing weight, and are isolated from shocks caused by the whisker's own motion.

How rats don't get confused by their own whiskers: Evolutionary "patents" in whisker follicles separate self-motion from external touch

A study in Nature Communications reveals a subtype of touch sensors in the whisker follicle that is located near the center of mass and rests on a collagen ring that acts like a “stabilizing weight” — so the rat ignores whisker vibrations and responds precisely
Satellite image of a winter storm in the American northwest. Source: CIRA

Pacific winter storm track moving north faster than forecast

Shifting storm tracks due to climate change is warming and drying out large areas of the American Northwest.
The quantum interference experiment as seen under an electron microscope. Using bilayer graphene, scientists controlled the trajectory of an anion in the material (in red). They made its wave go around an island containing a magnetic field and other anions (in green) and then brought it back together with the original wave to study its properties. The electrical gates (in dark gray) allow scientists to direct the anions along specific paths in the material and also determine the density of electrons in the island.

Weizmann Institute scientists identify quantum "memory particles" – a step towards a durable quantum computer

Weizmann Institute of Science scientists have found new evidence for the existence of a system of particles that "remembers" which quantum states it was in before, taking another step toward a fault-tolerant quantum computer.
Prostate cancer. Illustration: depositphotos.com

Making drug resistance a weak point in metastatic prostate cancer

A new computational tool, SpotNeoMet, developed at the Weizmann Institute, detects resistance mutations that recur in many patients and create neoantigens – a possible target for “precision” immunotherapy for broad patient groups
DARE cells (their bodies are marked in green) and NARE cells (their bodies are not marked) in the epithelial tissue from which the fly wing develops. In red – the nuclei of the cells as they divide. The scientists discovered that NARE cells receive signals from neighboring DARE cells that tell them to divide

Resurrected tissues

The ticking of the biological clock in a human cell throughout the day. A fluorescent marker allows scientists to see "what time is it" at any point in time

New study reveals key role of sex hormones in our biological clock

The findings may shed new light on disruptions in the biological clock during menstruation, pregnancy, and menopause.
Dr. Ohad Waneshk and the biochip. Photo: Weizmann Institute Spokesperson

The biochip that is already ready for the next pandemic

A new DNA chip from the Weizmann Institute of Science produces dozens of viral antigens on silicon in a single experiment and rapidly maps the immune “fingerprint” of subjects – a tool that could accelerate the development of tests, vaccines,
Human lung cancer tissue under the microscope. The helper macrophages (in red) are surrounded by enzymes (in yellow) that activate the stimulating part of the antibodies they develop. This targeted action prevents damage to healthy tissue.

Neutralize the defense, go on the offensive: Smart antibodies to fight cancer

Researchers from the Weizmann Institute of Science have identified immunosuppressive macrophages in tumors and developed smart molecules called MiTEs that target the TREM2 receptor and locally activate IL-2 – with the aim of overcoming resistance to immunotherapy without causing side effects.

Man accelerates, nature declines: Two studies shed new light on 170 years of intensifying human activity

If we quantify the extent of human movement on Earth, we find that we move 40 times more than all land animals combined; if we look at the timeline, we see that while the weight of farm animals has skyrocketed
The gas giants Jupiter and Saturn have strong easterly winds around the equator, while the ice giants Uranus and Neptune have westerly winds. The new model establishes a direct relationship between wind direction and atmospheric depth.

As deep as the atmosphere

New model explains wind direction on giant planets
Latham Island – more than 40 kilometers east of the coast of Tanzania and about 50 dunams in size

Bat Island: Going to the Edge of the World to Understand the Brain

Neuroscientists from the Weizmann Institute traveled to a remote island near Zanzibar to record the brain activity of mammals in the wild for the first time and study how the internal compass they use to navigate works.
A brain that runs away from losses. Illustration: depositphotos.com

Brain runs away from loss: This is how the brain makes adventurous decisions to avoid losses

Weizmann Institute and Ichilov Institute study reveals, using electrodes deep in the brain, how loss avoidance mechanisms affect learning, memory, and anxiety and post-traumatic stress disorders
The developing brain of a two-week-old mouse pup under the microscope. The oxytocin system is highlighted in green and a light-sensitive protein is highlighted in red. The combination of colors causes the oxytocin cells that also successfully express the protein to be colored yellow. In blue - the cell nuclei

Spotlight on the developing brain: Separation in early childhood alters the oxytocin system

Weizmann Institute of Science scientists have developed a new optogenetic technology that allows them to study the activity of the oxytocin system deep in the young brain. Their findings show that this protein, known as the "love hormone," influences the coping of mouse pups.
A prototype Mars rover built by students at Tel Aviv University. Photo: Tel Aviv University

From Tel Aviv University to Mars

A group of students from the Fleischmann Faculty of Engineering at Tel Aviv University initiated, designed, and built a space rover – as part of the TAUverIL project led by Prof. Yoram Reich and Danny Berko, with the aim of participating in an international competition in Poland.
Five-day-old zebrafish embryos under a microscope: the normal embryo (top) and the transgenic embryo (bottom) carrying the gene with the disease-causing mutation. It can be seen that in the transgenic embryo the main lymphatic vessel is abnormally enlarged

From the clinic to the aquarium: New zebrafish-based drugs for a rare lymphatic disease

A unique collaboration between the Weizmann Institute of Science and Sheba Medical Center led to the discovery of two potential drugs for a life-threatening disease of the lymphatic system.
The straw that broke the dam: Archaeological samples of microscopic straw that was embedded in mortar during construction and paved the way for an extraordinary dating achievement. Photo: Dr. Johanna Regev / Scientific Archaeology Unit, Weizmann Institute of Science

Carbon-14 dating determines: The Pool of Siloam in Jerusalem was built in 800 BCE to deal with a climate crisis

New research by the Israel Antiquities Authority and the Weizmann Institute dates the impressive dam wall from the time of the Judean kings Joash or Amaziah, which was built in Jerusalem some 2,800 years ago as a solution to the climate crisis and water shortage.
After the Big Bang, an interstellar cloud of gas and dust composed of the elements silicon (gray), sulfur (yellow), and argon (purple) remained.

Giant star caught naked, revealing source of silicon and sulfur formation

An international team of scientists, led by Northwestern University and the Weizmann Institute of Science, has identified a new type of supernova that provides a rare glimpse into the depths of stars and reveals sites of production of heavy chemical elements.
From right: Dr. Naama Darzi, Prof. Ayelet Erez, Dr. Natalie Rosenfeld and Dr. Elizaveta Bab-Dinitz. Photo by Weizmann Institute Spokesperson

It's all in the head: Blocking the communication channel between the brain and liver may prevent life-threatening weight loss in cancer patients

Research at the Weizmann Institute of Science demonstrates how communication between the brain and the body's organs plays a critical role in health and disease
Magnetic resonance imaging (MRI) findings of the brain in three children with a missing copy of Chaser. Scans taken at 8 months or 4 years of age (top row) show structural changes in the brain: shrunken frontal regions, a relatively small brainstem (indicated by asterisks), and abnormal development of the nerve sheath (myelin) in deep areas of the brain (indicated by arrows). These changes were barely visible in scans taken at XNUMX month of age (bottom row)

A global genetic pursuit

Artificial intelligence acceleration. Illustration: depositphotos.com

Collaboration between Weizmann Institute and Intel accelerates AI performance

Algorithms developed by Weizmann Institute of Science scientists and Intel Labs researchers enable millions of AI developers worldwide to harness the combined power of artificial intelligences that "think" together.
AI double will test personalized medicines. Illustration: depositphotos.com

A personal AI double will predict diseases – and help prevent them

Based on the advanced database of the Human Phenotype Project and artificial intelligence models, Weizmann Institute of Science scientists created a "digital twin" that will help predict the medical future of each participant.
A fluorite crystal containing atoms of the radioactive substance thorium-229, which was used to precisely measure the absorption spectrum of atomic nuclei at the PTB institute in Braunschweig, Germany. Previously, researchers had to capture several atomic nuclei in each experiment and test them with a single radiation frequency, which took a long time to achieve accurate measurements. The PTB measurement used a crystal in which about a quadrillion (a thousand trillion) atoms are embedded, allowing many tests to be performed simultaneously using precise laser beams. Credit: PTB

The dark side of time: A nuclear clock may reveal dark matter

A nuclear clock is the next big promise in measurement. Weizmann Institute of Science scientists have devised a method that allows us to harness tomorrow's technology to search for dark matter today.
Overexpression of B2-SINE family genes in retinal ganglion cells (top) led to accelerated growth after injury. Below: Ganglion cells after injury without overexpression of B2-SINE

Weizmann scientists discovered hundreds of molecules that accelerate nerve regeneration – including in the brain

The study, published in the journal Cell, reveals a new role for rare RNA molecules that help peripheral nerves and even encourage the regrowth of nerve cells in the brain. A breakthrough in the treatment of degenerative diseases and rehabilitation from injuries
Large-scale quantum computing. Illustration: depositphotos.com

Quantum Art Unveils Roadmap: Quantum Computer with a Million Qubits by 2033

The Israeli company that grew out of the Weizmann Institute is setting ambitious goals for developing commercial quantum computing – with a technological advantage as early as 2027.
Human fat cells. Illustration: depositphotos.com

The Fat Sense: How the Nervous System Affects Metabolism and Obesity

Weizmann Institute researchers have found that nerve cells sense mechanical changes in fat tissue and regulate the body's energy burning. Suppressing this mechanism makes mice immune to obesity and diabetes
Tolerance Patrol: Mouse lymph tissue with a cluster of immune system cells (marked in green, red, and blue) that communicate with each other and lead to food tolerance

The immune system knows when not to fight — and thus prevents food allergies

Weizmann Institute of Science scientists reveal how the immune system allows us to eat whatever we want, without developing an allergy or disease.
Various modern concrete objects with dramatic lighting on a dark background.

MRI with one nanometer resolution

Weizmann Institute scientists have developed a nano-MRI method that allows imaging of single molecules at room temperature
"The results suggest that whiskers are an integrative and multisensory sensory system. It may have evolved this way throughout evolution to help mice locate food or protect themselves from predators." Illustration: depositphotos.com

The whisker that hears: Mice identify objects by the sounds their whiskers make

New research from the Weizmann Institute presents a fascinating turn in sensory research – mice whiskers not only sense touch, but also produce sounds that are captured by the auditory system and used to identify objects.
The exterior of the Atlas experiment at CERN. Illustration: depositphotos.com

The prestigious Breakthrough Prize was awarded this year to the Atlas experiment at the Ceren particle accelerator, which involves about a hundred Israeli researchers.

The ATLAS experiment involves four groups from Israel, consisting of approximately 100 researchers from Tel Aviv University, the Technion, the Weizmann Institute, and Ben-Gurion University.