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Figure 1. Methods for vaccine production before the corona epidemic. (Courtesy of the Committee for the Nobel Prize in Physiology or Medicine): Use of a weakened or inactive virus and a recombinant protein (the virus) that is transferred to the body via a viral vector and activates the immune system. Courtesy of the Nobel Prize Committee

Nobel Prize in Medicine 2023 for the pioneers in the field of mRNA who accelerated the vaccines for Corona

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Kariko and Weissman immediately realized that their discovery was of enormous significance for the possible use of messenger RNA in medicine. These important findings were published in 2005, 15 years before the outbreak of the Corona epidemic.
mRNA. Illustration: depositphotos.com

Moderna and IBM will investigate the development of mRNA-based therapies with the help of quantum computing and artificial intelligence

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As part of the collaboration, IBM will provide modern scientists with access to quantum computing systems, and they will learn how quantum computing technologies can be applied to problems that were previously intractable for classical computers.
grow old. Illustration: depositphotos.com

Age slowly, live longer

A study in C. elegans worms found that a type of small RNA molecule is essential for slowing the rate of aging and prolonging the lives of animals with a damaged reproductive system
mRNA. Illustration: depositphotos.com

Scientific breakthrough: for the first time in the world an mRNA vaccine against deadly bacteria

Researchers succeeded for the first time in the world in developing a vaccine against a deadly bacterium, opening the door to mRNA vaccines also against antibiotic-resistant bacteria
Caution: The Omicron strain of the corona virus is spreading. Illustration: depositphotos.com

Are the booster vaccines for corona effective against the Omicron strain? Everything you need to know

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It seems that leumicron has the ability to bypass existing immunity, either from a vaccine or in convalescents. However, it seems that it is more difficult to cause a serious illness in those vaccinated with the booster shot, so experts recommend getting vaccinated as soon as possible
A variant or omicron strain of a corona virus. Illustration: depositphotos.com

Is Omicron more contagious than Delta? A virus evolution expert explains what researchers know and don't know

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The omicron variant contains many mutations in the spike protein, which facilitate the penetration of the virus into cells
Stroke. Photo: depositphotos.com

This is how the body sets up a unique emergency team against stroke using RNA-guide fragments

Guide RNA fragments, which until recently were known as the breakdown stages of the guide RNA on the way to their elimination from the body, were discovered in a new study led by Prof. Hermona Sorek from the Hebrew University, as molecules of great importance in preventing the collapse of the immune system following a stroke, the risk of which increases in corona patients
3. In the diagram: on the left: the vaccines. mRNA vaccines are based on introducing artificial mRNA into cells so that it will serve as a template for building the viral protein that will activate the immune system. Shortly after the entry of the mRNA molecules into the cell, they begin to initiate the production of the immune proteins required by the cell. mRNA contains several chemical changes, which improve its activity in the cell. Right: the natural mechanism. The study published in Nucleic Acids Research shows how similar chemical modifications, naturally present in mRNA, serve as binding sites for regulatory factors. This link affects the activity of the ribosome and thus enables the production of proteins in more precise quantities and in accordance with the needs of the organism.

Dynamic, sophisticated and sensitive to the environment: this is how the mRNA formulates its instructions to the ribosome

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Illustration of the study Photo credit: Ella Maru Studio.

The development of the corona vaccine can also lead to a gene therapy process for cancer

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Researchers from Tel Aviv University, led by Prof. Dan Parr, succeeded in eliminating cancerous tumors from the inside using messenger RNA (mRNA), which is used to develop vaccines for corona, and instead of corona proteins, they expressed crisper proteins that interrupted the tumor
mRNA vaccine for corona. Illustration: depositphotos.com

Moderna's COVID-19 vaccine achieved 94.5% efficacy in the clinical trial

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A first interim analysis of the experiment's findings included 95 participants who were infected with Corona, 90 of whom are from the control group * All five who got sick despite the vaccine were asymptomatic or in a mild condition * Israel is among the first in line when the vaccine is approved
Prof. Ilana Gozes. Photo: Tel Aviv University

An experimental Alzheimer's drug may help children with autism

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Illustration: pixabay.

When the genetic messenger discovers independence

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"Throughout evolution, the cells that knew how to produce proteins in the most 'cheap' way acquired a huge advantage. You can say that the one who was the most economical survived." Source: Weizmann Institute magazine.

A traffic light of bacteria

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common denominator at the cell level. Embryonic (A) and evolutionary (B) development. Illustration courtesy of the Technion

Evolution between the layers

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The act of genetic translation using mRNA. From Wikipedia

Technion researchers have developed a new approach that simplifies a complex biological model

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From the right (standing): Roni Oren, Dr. Tali Melkman-Zahavi, Sharon Cardo-Russo. (Sitting): Amitai Mandelbaum, Natalie Rivkin and Dr. Eran Hornstein. a positive factor

micro-macro

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Prof. David Gavol and Prof. Shmuel (Shapilka) Rosenblatt

A new method for creating induced stem cells

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Coloring of the meeting areas between nerve cells (green) and muscle (red). The yellow staining represents complete overlap between the nerve cells and the muscle in normal mice (bottom). In transgenic mice, which lack microRNA in nerve cells that innervate muscles, only the muscle staining is visible (above, in red), because the nerve in the junction area is diseased. Illustration: Weizmann Institute

ALS - suddenly in the middle of life

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The motor neurons, which control voluntary muscle movement, gradually degenerate. As a result, the patient loses the function of most muscles
From the right: Dr. Oleg Raitskin, Dr. Eyal Kimchi, Prof. Yosef Sperling and Prof. Ruth Sperling.

Copy quality control

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Mapping the translation process of DNA into proteins using RNA

Splicing code cracker

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Root Canal

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The molecular basis of Down syndrome

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It was discovered how "molecular machines" begin to activate the genes

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DNA sequence

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Collaboration between Rosetta Genomics and Rabin-Bilinson Medical Center in microRNA-based diagnostic tools

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