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Cancer research - basic

Cancer mutations. Image: depositphotos.com

A fast, accurate and cost-effective method for detecting cancer-causing mutations

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The new technology we developed provides accurate data on the nature of the mutation based on the RNA sequencing of the tumor only - that is, without the need for DNA sequencing of the tumor and any sequencing of the healthy tissue
Right: Immune clusters in the liver of a mouse containing ILCs, and within them cancer cells (in red). On the left: immune clusters in the liver of a mouse from which ILCs have been removed, and within them cancer cells. The cancer cells thrive more in the mouse liver which contains ILCs

The immune system gets tired - and the cancer spreads

Pools of immune system cells taken from patients and mice with liver cancer and melanoma, partly composed of tired immune cells
A conceptual illustration of the chess battle between the cancer cells and the anti-cancer drugs. Most cancer deaths are related to the development of drug resistance and the formation of metastases. In both processes, the cancer cells face difficult and new challenges and a strain: finding a bypass for the drug, or a way to adapt to a foreign and hostile tissue. Unfortunately, the cells often manage to overcome these challenges. How does this happen? This is a complex process, and among other things, the cells go through a process of learning, which involves trial and error, while searching among a large number of configurations and internal states. The theory of learning theory constitutes a mental and mathematical framework for understanding these processes. A review of the current literature shows that basic concepts of learning theory provide an explanation for results that do not correspond to the popular concept. Linking the search process to a concrete mathematical model demonstrates its feasibility. (Illustration: Harel Spring)

Lethal learning: a new interpretation of adaptive mechanisms of cancer cells

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Natural cancer antibodies (green) bind to ovarian cancer cells. Cell nuclei in blue. Photographed using a confocal microscope

The new players in the war on cancer

Our immune system has a powerful and accurate weapon to destroy bacteria and viruses. It is possible that in the future it will also be possible to harness it against malignant tumors
Using nanoparticles to fight cancer. Courtesy of the researchers, University of Tokyo

Using nanoparticles to fight cancer

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Researchers have recently succeeded in developing innovative bio-nanoparticles derived from corn designed to tune into and destroy cancer cells, thanks to the body's own immune system
Cancer cells are marked with luminescent detector molecules developed in Prof. Margolis' laboratory

The sunrise of the detector warns of cancer

An advanced molecular structure may detect and report intracellular activity that may cause cancer
The chemotherapy treatment increases the secretion of LOX from T cells, and as a result the extracellular environment in the lungs changes in a way that encourages the formation of metastases. Photo: Technion spokespeople

Cancer metastases sometimes form following successful chemotherapy treatment

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Rare crabs. Credit: Shutterstock

Rare crustaceans and genomic sequencing

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Oncologists use genomic sequencing to try to refine the treatment of rare cancers - about this and more in the following interview with Dr. Sharon Pels - an oncology expert
Cancerous brain tumor. Illustration: depositphotos.com

catch the disease

The institute's scientists located a molecule that irreversibly attaches to a protein that contributes to the development of malignant tumors. Their findings may lead to the creation of a new cancer drug
cancer cell a href="https://depositphotos.com. ">Illustration: depositphotos.com

Medical technology developed at the Technion improves the effect of anti-cancer drugs

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The technology, based on the Nano-Ghosts platform, makes it possible to reduce the dose of the drug a million times without harming its effectiveness
blood vessel. Illustration: depositphotos.com

The distribution of attention of blood vessels

The scientists of the institute discovered that the blood vessels "separate" between cell division and branching in new directions. The findings imply that chemotherapy treatments may encourage the growth of blood vessels in the tumor
Schematic description of the research findings - dependence of the cell capture on the density of the cells

Nanofibers that prevent the spread of cancer cells in the brain

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Researchers have used high-density nanofibers that mimic the brain's microenvironment to trap cancer cells in research that paves the way for the development of innovative therapeutic solutions for aggressive brain cancers
Cancer treatment. Illustration: depositphotos.com

Break the boundaries of immunotherapy

The method that may make the new generation of cancer treatments accessible to more patients
Oncology drugs. Illustration: depositphotos.com

The dual agents of the immune system

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Prof. Mira Barda. Photo: Bar Ilan University

Blood cancer treatment without endangering healthy cells

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A cancer cell divides. Illustration: depositphotos.com

"Silent" mutations can predict the development of cancer cells

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Researchers from Tel Aviv University have shown that silent mutations, i.e. those that do not change the amino acid sequence of the proteins, are also not innocent
Blood cancer cells compared to normal blood cells. Illustration: depositphotos.com

Another component in the mechanism that causes leukemia was discovered

In a study conducted on blood samples from patients and those recovering from leukemia, unique sequences were found that control genes that contribute to the spread of the disease. "By investigating these genes we can learn how to prevent the disease from progressing and even develop future drugs to prevent it"
The most common types of brain cancer. Illustration: depositphotos.com

A new immunotherapy helps the cells of the immune system locate the deadly glioblastoma brain cancer cells and eliminate them

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The researchers relied on the CAR-T technology, which uses genetic engineering to improve the function of the immune system's T cells in their war on cancer cells. According to the researchers, the method they developed may help patients with various types of brain cancer, as well as solid tumors in other organs
Drug transport into cells. Courtesy of Prof. Dan Farr, Tel Aviv University

Progress in transporting drugs only to cells infected with cancer or viruses without harming healthy ones

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Prof. Dan Farr, Tel Aviv University: "Our development actually changes the world of antibodies. Today we flood the body with antibodies that are indeed selective, but also damage the healthy cells. We removed non-inflammatory cells from the game, and with a simple injection we succeeded in damaging only the inflammatory cells at that moment Given"
A lung lobe of a mouse with cancer cell metastases expressing phosphorylated protein, to allow quantification and measurement of the metastases. Credit: Dr. Avi Maimon.

Groundbreaking research: a new protein has been found that significantly inhibits cancer metastasis

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A protective protein, which was generally known to be effective against blood clots, was found to be capable of inhibiting the most violent means of cancer in the human body - metastasis. Prof. Tal Borshtin-Cohen, the leader of the research, believes that the surprising discovery explains why there are quite a few anti-cancer treatments that fail: "The understanding that protein S helps the body fight metastases is a warning light for anti-cancer treatments, which are designed to inhibit this protein's pathway"
Prof. Ronit Sachi Fainero and Elam Yeni. Photo: Tel Aviv University

Activating the brain's immune system against the deadly glioblastoma cancer makes it possible to stop its spread

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Researchers from Tel Aviv University have identified a failure in the brain's immune system that increases the division and spread of glioblastoma cancer cells instead of inhibiting them. Now they are looking for ways to turn the situation around
Prof. Yaakov Nachmias. Photo: Hebrew University Spokesperson

Rapid development of medicines with the help of bionic chips, without the need for animal experiments

Targeted elimination of a cancer cell. Photo: depositphotos.com

Researchers at the Technion have developed a new approach for the selective elimination of cancer cells

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The research group of Prof. Tomer Shlomi from the Faculty of Computer Science, the Faculty of Biology and the Lockey Center for Life Sciences and Engineering at the Technion discovered a process based on which it is possible to selectively and specifically damage cancer cells without causing damage to healthy tissue
The consequences of damage to the control mechanism for the separation of chromosomes (SAC) and the KIF18A enzyme in normal cells compared to aneuploid cells

New research reveals a weak point in cancer cells

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Researchers from Tel Aviv University shed light on a 140-year-old mystery in an article published in Nature. The research shows for the first time how an abnormal number of chromosomes (aneploidy) - a unique feature of cancer cells that has been known to researchers for decades - can become a weak point of these cells. The research may in the future lead to the development of drugs that will take advantage of this weak point for targeted damage to cancer cells
T cells of the immune system attack a cancer cell. Illustration: shutterstock

Cancer cells' secret recipe for protein production may become a weapon against them

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