Diseases

Two human heart models, one simulating a healthy heart and the other a diseased one. Photo: Dassault Systèmes

Members of the "Living Heart" project are testing a new generation of a customizable model

  • No comments
Dassault Systèmes enters the next phase of the "Living Heart" project with AI-based virtual twinning * Matching and automation of virtual models of the heart, based on AI, will help simplify and accelerate
Intra-abdominal fat. Illustration: depositphotos.com

New study reveals: The link between intra-abdominal fat and metabolic risk

  • No comments
Comprehensive research by Ben-Gurion University and international partners indicates the importance of reducing intra-abdominal fat for improving metabolic health, even with moderate weight loss.
A microscopic image of tissue stained in purple, red, and green to identify various cellular components.

Two ways to a broken heart, two ways to heal

Illustration: depositphotos.com

"The Early Warning Signs of Cancer: Epigenetic Discoveries That Inspire Hope"

  • No comments
New study reveals that cancer risk may be determined before birth, suggesting new directions for diagnosis and treatment
Minister of Science and Technology Gila Gamliel and the head of the Isfaia Local Council, Munib Sabaa. Photo: Idan Media, for the Government Advertising Bureau

Oral bacteria linked to increased risk of stroke

  • One response
The lead researcher from the National Heart Disease Center in Osaka, notes: "In the future, if a rapid test is developed to identify harmful bacteria in the mouth and intestines, we could use this information to calculate stroke risk."
Transporting medicines. Illustration: depositphotos.com

Innovative technology for biological nanoparticles enables combined treatment against cancerous tumors

Researchers from Tel Aviv University have developed an innovative platform based on nanoparticles, which enables the precise transport of two drugs at the same time to cancerous tumor sites, while improving treatment efficiency and reducing toxicity to healthy cells.
Ground level ozone has negative effects on human health. Photo: pexels, german latasa

How does ozone pollution affect diabetes morbidity?

Heart attacks happen at night. The image was prepared using DALEE and should not be considered a scientific image.

Why do more heart attacks and asthma occur at night?

Weizmann Institute of Science scientists have discovered why the small hours of the night may be prone to disaster
Starving cancer through sugar deprivation. The image was prepared using DALEE and is not a scientific image

Breakthrough in brain cancer treatment: starving cancer cells causes them to burn themselves

  • 6 תגובות
The D'20 peptide inhibits the cancer-causing enzyme MMP7. The image was prepared using DALEE and is not a scientific image

A new stable and selective inhibitor of a cancer-causing enzyme has been revealed in a new study

  • No comments
Researchers from the Hebrew University, the Weizmann Institute and the University of Tokyo have developed an innovative peptide that suppresses the activity of the MMP7 enzyme associated with cancer progression, with the potential for targeted therapies in aggressive cancers.
Lung cancer. Illustration: depositphotos.com

A new blood test for the early detection of tissue damage caused by cancer treatments

  • No comments
A method developed at the Hebrew University allows early detection of lung damage among cancer patients receiving antibody-based treatments, using a simple non-invasive blood test
Fruit flavored electronic cigarettes are dangerous. can cause lung cancer and other diseases. The image was prepared using DALEE and is not a scientific image

A new study in PNAS reveals that fruit-flavored e-cigarettes harm the immune system of the lungs

  • One response
The Cancer Society: "The reason for using sweet flavors is an attempt to bring teenagers into the circle of users. Their sale must be banned immediately"
Section of breast tissue from a triple negative breast cancer (TNBC) patient, on the right, and healthy breast tissue, on the left. In the cancer patient, the cancer cells (indicated in light blue) surround cells in their microenvironment that express a high level of CD84 (indicated in purple)

burn the bridges of cancer

The institute's scientists revealed how aggressive breast cancer disrupts the immune response against it, and developed a treatment using an antibody that may be suitable for many types of cancer
Prof. Carmit Levy and Prof. Yaron Carmi

Researchers from Tel Aviv University have discovered a new cancer mechanism, the activation of which eliminates cancerous tumors

  • One response
Prof. Carmit Levy: Immunotherapy has revolutionized cancer treatment," explains Prof. Carmi, "but about 50% of patients do not respond to the standard treatment - the PD-L1 protein. We found a new protein Ly6a against which treatment with an antibody
A sample from a tumor of a human patient with the most common lung cancer (adenocarcinoma). The presence of senescent cells expressing the proteins P16 (in red) and PD-L1 (in green) can be detected. The cell nuclei in the sample are marked in blue

to open blockages in the immune system

Heart Attack. Illustration: depositphotos.com

Discovery of violations

Copaxone may protect heart muscle cells and improve its function after a heart attack
Lung cancer. Illustration: depositphotos.com

Research at the Faculty of Biology at the Technion paves the way for innovative lung cancer treatment

  • No comments
The layers of glioblastoma tumors: first layer of necrotic tissue in the center of the tumor that does not receive oxygen supply (red), second layer of cancer cells that mimic fetal connective tissue (yellow), third layer of immune cells (green) and blood vessels (white) and fourth layer of tumor cells that receive oxygen and imitate normal tissues in the brain (in pink and light blue)

peel back the layers from the brain tumors

In two recently published studies, Weizmann Institute of Science scientists mapped common brain cancer tumors with unprecedented resolution, and identified a possible reason why some patients do not respond to a new treatment
cancer cell Illustration: depositphotos.com

What predicts your cancer type?

  • One response
Diabetic neuralgia. Illustration: depositphotos.com

Lexicon Pharmaceuticals selects Medidata to promote first non-opioid drug in two decades for diabetic nerve pain

  • No comments
Imaging of human small intestine tissue using a fluorescence staining method that allows marking a large number of proteins at the same time and thus mapping which proteins are produced in the entire basal area of ​​the intestine

navigate the digestive tract

genetic scan. Illustration: depositphotos.com

Artificial intelligence revealed cancer causes hidden in "junk" DNA

  • No comments
Research at the University of Sydney suggests that non-coding DNA, which makes up 98% of our genome and was previously considered "junk" – that is, lacking a defined function or redundant, may play a crucial role in cancer diagnosis and treatment.
Histological section of the nasal cavity and turbinates of a mouse that received a nasal vaccine

The immune cells discovered under the nose

The scientists of the Weizmann Institute of Science have discovered antibody-producing cells in the bone tissue of the nasal concha and thereby plant hope for the development of more effective nasal vaccines and new treatments for allergies and neurological and autoimmune diseases
the muscles and the skeleton. Illustration: depositphotos.com

between the muscles and the skeleton

Researchers discovered that in mice lacking a protein that is responsible for muscle contraction, fusion developed between the vertebrae of the spine, which may lead to scoliosis and other orthopedic diseases
Cells with cancerous p53 proteins (in red), in the presence of the accompanying protein DNAJA2 (left) and in the presence of its version without a "hairpin" (right). In its presence, the structure of the cancerous proteins is stabilized and they do not stick to each other and therefore remain scattered throughout the cell. In its absence, the cell is not colored red since the proteins form aggregates (red dots) that the cell can recognize and destroy (in blue - the genetic material in the cell nuclei)

stick a pin in the tumor

Weizmann Institute of Science scientists have discovered a new cellular mechanism for identifying proteins whose 3D structure has been unraveled, thereby revealing a targeted target for cancer treatment
How the "aging" mechanism called senescence is activated for a short time after an injury to the heart of mice as an essential part of the heart's healing process. Courtesy of the researchers

Researchers have discovered a mechanism of heart tissue regeneration

  • 3 תגובות
Researchers from the Weizmann Institute found that the biological processes associated with aging, it turns out, also do the opposite and help the regeneration of heart tissue * The study emphasizes the need to be careful when using drugs that aim to get rid
The skulls were examined using microscopic analysis and CT scanning. Credit: Tondini, Isidro, Camaros, 2024.

A 4,000-year-old Egyptian skull reveals surgical attempts to treat cancer

  • No comments
Scientists were amazed by the discovery of cut marks around cancerous tumors on an ancient Egyptian skull, which allowed them to better understand how the ancient Egyptians tried to treat the disease
Transplantation of an engineered kidney in a patient. Science site credit via DALEE. The image should not be seen as a scientific image.

A person received a pig kidney - with 69 genetic changes

  • 3 תגובות
The changes are intended to prevent the body from becoming infected with dormant viruses that may be present in the kidney, and in any case the kidney is designed to fit the specific patient
Brain cancer cells. On the right: cells in which the gene coding for 4EBP was silenced that failed to grow a tumor, on the left: the control cells in which a tumor is detected. Credit: Dr. Tal Levy

Glucose starvation also as an anti-cancer treatment

  • 3 תגובות
A new approach to treating brain cancer forces glucose-starved cancer tumor cells to burn themselves out. The method was developed in the laboratory of Prof. Barak Rothblatt at Ben-Gurion University in the Negev and is based on a decade of research
The polymer conjugated to the peptide and the drug (P-Esbp-DOX) binds to the E-selectin protein, which is expressed on the surface of endothelial cells that line the blood vessels in the tumor environment, enters the cells, releases the drug inside them and kills them.

inhibit the migration of cancer cells

Researchers have developed polymers that bind to proteins that play a key role in cancer and inflammation, thus preventing - in mice - the formation of metastases and slowing down the progression of arteriosclerosis and hepatitis
A fitness pill. Credit: The Science website via DALEE

New 'workout pill' can cause fitness benefits without exercise

  • No comments
Researchers report new compounds that appear to be able to mimic the physical drive of exercise—at least in rodent cells. This discovery may lead to a new way to treat muscular dystrophy and other medical conditions in people,
Smoking and ultraviolet radiation end the effects of aging. Credit: The Science website via DALEE

The cause of aging: cumulative damage from factors such as radiation and smoking causes low expression of long genes

  • No comments
Dutch researchers found that this process happens all the time and damages all genes, but the longer the genes, the more likely they are to be damaged because they have more sites. Especially the big damage is
Advances in cancer immunotherapy. The image was produced by DALLE 3 artificial intelligence software and is intended for impressions. It should not be seen as a scientific picture

Technion researchers present a significant improvement in predicting the success of immunotherapy treatments

  • No comments
The technology developed by Prof. Yuval Shaked's research group was registered as a patent and is now in the process of being commercialized
Entry of an insulin molecule into a human cell. Illustration: depositphotos.com

Why are diabetics more susceptible to respiratory infections?

35% of the corona patients who died in the epidemic were diabetics. In a new study, Weizmann Institute of Science scientists reveal that high blood sugar levels disrupt the immune system's ability to fight lung infections and present
A girl with juvenile diabetes injects insulin. shutterstock photo

How to manage diabetes in war and crisis situations

Stress and anxiety can worsen health conditions, including diabetes. Awareness and preparation reduce risks
DNA sequencing. Illustration: depositphotos.com

Proteins in the cancer network

Researchers are trying to find treatments adapted to protein networks that characterize cancer tumors
blind rat Illustration: depositphotos.com

Build muscle and stay young

Researchers have discovered that the skeletal muscle composition of the blind rat is preserved throughout its life, delaying its aging
Tissues removed from mice implanted with lung cancer cells engineered to produce high amounts of PSME4 (left column) or unmodified cancer cells (right column). When the protein is expressed in a high amount, the tumor is larger (top row, the tumor cells are marked in intense and concentrated purple), the number of T cells that can fight the tumor is lower (middle row, in white), and there are more cells that suppress the immune response (bottom row, in green)

The cancer to the basket and eliminated

The cell's garbage disposal system changes in cancer and allows it to escape the immune system
Histological sections of the leg muscles without injury (left) and five days after it (center, right) in a control mouse and a transgenic mouse. It can be seen that the area of ​​the muscle fibers that develop after the injury is smaller in the transgenic mouse, which indicates a disturbance in the differentiation of the stem cells into muscle cells

overcome the damage

Researchers have discovered that two epigenetic events (removing and adding methyl from DNA) lead to the differentiation of stem cells into muscle cells and thus to the regeneration and healing of muscles after their injury
The working principle of W. Photo: Ariel University

A robotics system to eradicate lung cancer will allow live imaging during examination and treatment

  • No comments
The error rate of the existing biopsy tests is 30%. Mistakes that are fatal because the test turns up clay but the cancer exists and continues to spread. Good imaging can improve accuracy
From 0 to 100%: the prediction provided by the model for metasynergy between different drugs

Drug combination in the fight against cancer: an innovative approach that combines biology, chemistry and artificial intelligence

  • One response
Illustration: Sally Neve

A breakthrough in the treatment of herniated disc

Tissue engineering offers a solution for the treatment of disc herniations: an implant that combines synthetic hydrogel and living cartilage cells
A "ghost" heart is a pig heart that has been prepared so that it can be transplanted into humans. Provided by Doris Taylor

"Ghost" hearts from a pig and the patient's stem cells will replace the need for heart donations

  • 2 תגובות
Today, patients needing a heart transplant have to join a waiting list, and hearts become available when someone else dies. Because there are not enough hearts, only critically ill patients are put on the waiting list
Damage to the motor nerves in Duchenne patients. Illustration: depositphotos.com

Improving the function of the heart muscle in Duchenne patients

Producing heart cells from skin cells made it possible to discover defects that lead to heart failure
Human lung cancer cells with the L858R mutation in the EGFR gene. In blue - the cell nuclei. In red - a protein that appears in the cell fluid when EGFR receptors are active and push the cell into uncontrolled division. Courtesy of the Weizmann Institute

A new biomarker may improve the treatment of lung cancer patients

  • No comments
A study of human cancer tissues grown in mice has suggested that a large group of lung cancer patients may be successfully treated with a drug currently approved for other cancers
tanning Illustration: depositphotos.com

Does the tan come in a delay? Say thank you

Revealing the mechanism that delays the appearance of tanning could help create treatments that will protect us from skin cancer
Electron microscope image of a lymphocyte cell on the surface of the chip. Photo: Estee Toledo and Dr. Guillaume Le Soux.

Cells, chips - and cancer research - the National Science Foundation

The ability of the cells of the immune system to inhibit the cancer cells depends to a large extent on the distance between the receptors by means of which they check and identify the "suspicious" cell
A new study by Prof. Ofra Bani from the School of Pharmacy at the Hebrew University of Jerusalem and Dr. Sharon Marims - dermatology specialist and senior physician at the dermato-oncology clinic at the Hadassah Medical Center and the Hadassah Cancer Research Institute, published in Science Translational Medicine courtesy of the Hebrew University

A new way to solve side effects of cancer treatment

  • One response
Researchers at the Hebrew University and the Hadassah Medical Center have developed an ointment to treat the severe side effects of targeted cancer treatment and significantly improve the quality of life of patients.
immunotherapy. Illustration: depositphotos.com

Development of new biological sensors to assess cancer patients' responses to treatments

  • No comments
A team of researchers from Ben-Gurion University of the Negev has developed a breakthrough technology that includes a revolutionary new test that will predict the response of cancer patients to immunotherapy with a higher percentage of accuracy than existing technologies. The results of the study have been published
Melanoma. Illustration: depositphotos.com

Researchers were able to identify how melanoma shapes its environment to spread in the body

Assessment: The new discovery may later lead to the development of a general vaccine against the deadly skin cancer