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The polymer conjugated to the peptide and the drug (P-Esbp-DOX) binds to the E-selectin protein, which is expressed on the surface of endothelial cells that line the blood vessels in the tumor environment, enters the cells, releases the drug inside them and kills them.

inhibit the migration of cancer cells

Researchers have developed polymers that bind to proteins that play a key role in cancer and inflammation, thus preventing - in mice - the formation of metastases and slowing down the progression of arteriosclerosis and hepatitis
A fitness pill. Credit: The Science website via DALEE

New 'workout pill' can cause fitness benefits without exercise

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Researchers report new compounds that appear to be able to mimic the physical drive of exercise—at least in rodent cells. This discovery could lead to a new way to treat muscular dystrophy and other medical conditions in humans, including heart failure and neurodegenerative diseases
Smoking and ultraviolet radiation end the effects of aging. Credit: The Science website via DALEE

The cause of aging: cumulative damage from factors such as radiation and smoking causes low expression of long genes

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Dutch researchers found that this process happens all the time and damages all genes, but the longer the genes, the more likely they are to be damaged because they have more sites. Especially the great damage is to nerve cells due to their inability to regenerate
Advances in cancer immunotherapy. The image was produced by DALLE 3 artificial intelligence software and is intended for impressions. It should not be seen as a scientific picture

Technion researchers present a significant improvement in predicting the success of immunotherapy treatments

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The technology developed by Prof. Yuval Shaked's research group was registered as a patent and is now in the process of being commercialized
Entry of an insulin molecule into a human cell. Illustration: depositphotos.com

Why are diabetics more susceptible to respiratory infections?

35% of the corona patients who died in the epidemic were diabetics. In a new study, Weizmann Institute of Science scientists reveal that high blood sugar levels disrupt the immune system's ability to fight lung infections and present a therapeutic approach that may save lives
A girl with juvenile diabetes injects insulin. shutterstock photo

How to manage diabetes in war and crisis situations

Stress and anxiety can worsen health conditions, including diabetes. Awareness and preparation reduce risks
DNA sequencing. Illustration: depositphotos.com

Proteins in the cancer network

Researchers are trying to find treatments adapted to protein networks that characterize cancer tumors
blind rat Illustration: depositphotos.com

Build muscle and stay young

Researchers have discovered that the skeletal muscle composition of the blind rat is preserved throughout its life, delaying its aging
Tissues removed from mice implanted with lung cancer cells engineered to produce high amounts of PSME4 (left column) or unmodified cancer cells (right column). When the protein is expressed in a high amount, the tumor is larger (top row, the tumor cells are marked in intense and concentrated purple), the number of T cells that can fight the tumor is lower (middle row, in white), and there are more cells that suppress the immune response (bottom row, in green)

The cancer to the basket and eliminated

The cell's garbage disposal system changes in cancer and allows it to escape the immune system
Histological sections of the leg muscles without injury (left) and five days after it (center, right) in a control mouse and a transgenic mouse. It can be seen that the area of ​​the muscle fibers that develop after the injury is smaller in the transgenic mouse, which indicates a disturbance in the differentiation of the stem cells into muscle cells

overcome the damage

Researchers have discovered that two epigenetic events (removing and adding methyl from DNA) lead to the differentiation of stem cells into muscle cells and thus to the regeneration and healing of muscles after their injury
The working principle of W. Photo: Ariel University

A robotics system to eradicate lung cancer will allow live imaging during examination and treatment

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The error rate of the existing biopsy tests is 30%. Mistakes that are fatal because the test turns up clay but the cancer exists and continues to spread. Good imaging can improve accuracy
From 0 to 100%: the prediction provided by the model for metasynergy between different drugs

Drug combination in the fight against cancer: an innovative approach that combines biology, chemistry and artificial intelligence

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Illustration: Sally Neve

A breakthrough in the treatment of herniated disc

Tissue engineering offers a solution for the treatment of disc herniations: an implant that combines synthetic hydrogel and living cartilage cells
A "ghost" heart is a pig heart that has been prepared so that it can be transplanted into humans. Provided by Doris Taylor

"Ghost" hearts from a pig and the patient's stem cells will replace the need for heart donations

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Today, patients needing a heart transplant have to join a waiting list, and hearts become available when someone else dies. Because there are not enough hearts, only critically ill patients are put on the waiting list
Damage to the motor nerves in Duchenne patients. Illustration: depositphotos.com

Improving the function of the heart muscle in Duchenne patients

Producing heart cells from skin cells made it possible to discover defects that lead to heart failure
Human lung cancer cells with the L858R mutation in the EGFR gene. In blue - the cell nuclei. In red - a protein that appears in the cell fluid when EGFR receptors are active and push the cell into uncontrolled division. Courtesy of the Weizmann Institute

A new biomarker may improve the treatment of lung cancer patients

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A study of human cancer tissues grown in mice has suggested that a large group of lung cancer patients may be successfully treated with a drug currently approved for other cancers
tanning Illustration: depositphotos.com

Does the tan come in a delay? Say thank you

Revealing the mechanism that delays the appearance of tanning could help create treatments that will protect us from skin cancer
Electron microscope image of a lymphocyte cell on the surface of the chip. Photo: Estee Toledo and Dr. Guillaume Le Soux.

Cells, chips - and cancer research - the National Science Foundation

The ability of the cells of the immune system to inhibit the cancer cells depends to a large extent on the distance between the receptors by means of which they check and identify the "suspicious" cell
A new study by Prof. Ofra Bani from the School of Pharmacy at the Hebrew University of Jerusalem and Dr. Sharon Marims - dermatology specialist and senior physician at the dermato-oncology clinic at the Hadassah Medical Center and the Hadassah Cancer Research Institute, published in Science Translational Medicine courtesy of the Hebrew University

A new way to solve side effects of cancer treatment

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Researchers at the Hebrew University and the Hadassah Medical Center have developed an ointment to treat the severe side effects of targeted cancer treatment and significantly improve the quality of life of patients.
immunotherapy. Illustration: depositphotos.com

Development of new biological sensors to assess cancer patients' responses to treatments

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A team of researchers from Ben-Gurion University of the Negev has developed a breakthrough technology that includes a revolutionary new test that will predict the response of cancer patients to immunotherapy with a higher percentage of accuracy than existing technologies. The results of the research were published in the prestigious magazine "Science Advances"
Melanoma. Illustration: depositphotos.com

Researchers were able to identify how melanoma shapes its environment to spread in the body

Assessment: The new discovery may later lead to the development of a general vaccine against the deadly skin cancer
Ovarian cancer. Illustration: depositphotos.com

The protein that helps the enemy

A certain essential protein increases the expression of another protein in cancer cells in the uterus - and this transforms its skin, encourages them to divide and thus contributes to the spread of the tumor
The thinness of the cancer. Illustration: depositphotos.com

Why do cancer patients lose weight?

The institute's scientists reveal how cancer leads to fatal emaciation and point the way to treatment
A smoker's lung compared to a clean lung. Illustration: depositphotos.com

Smoking on the balcony also harms children's health

Many parents think they are protecting their children by smoking on the balcony or near the bedroom window. But a new study by Tel Aviv University states that contrary to the popular opinion of those parents, restricting smoking to the balcony does not prevent the exposure of most children to the harm of tobacco smoke
Pancreatic cancer. Illustration: depositphotos.com

A breakthrough in the study of deadly pancreatic cancer

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Hebrew University researchers have discovered the molecular mechanism that allows pancreatic cancer to metastasize and become fatal. The discovery offers new treatment methods for the first time
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