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Silicon and gold to fight cancer

Researchers succeeded in destroying breast cancer cells by irradiating infrared light on special silicon compounds filled with gold atoms

Breast cancer tumor. Photo: from Wikipedia
Breast cancer tumor. Photo: from Wikipedia

Researchers have succeeded in destroying breast cancer cells by projecting infrared light on special silicon compounds filled with gold atoms. If the method also proves itself in human clinical trials, it could provide patients with a non-invasive alternative to surgical excision, and be used in combination with standard treatments against cancer, such as chemotherapy, in order to increase the effectiveness of these treatments.

"Hollow gold nanoparticles are able to generate heat if exposed to a laser that emits infrared light," said Dr. Haifa Shen, lead author of the paper describing the research findings. "Many studies have tried to use gold nanoparticles for the treatment against cancer, but their effectiveness was not quite good - a large amount of gold nanoparticles was needed to treat the tumor." Instead of using this approach, the researchers took advantage of a technology developed by the lead scientist of the study that aims to increase the response of the gold nanoparticles to infrared light.

"We discovered that the generation of heat from the nanoparticles was more efficient when we inserted them into porous silicon compounds," explains the lead researcher. The researchers found that when using light with a wavelength of 808 nanometers, the silicon particles filled with the gold particles heated the solution they were in by about twenty degrees Celsius within seven minutes. The assumption is that water molecules located directly around the particles have become even hotter. The experiments showed that cancer cell development was slower in the presence of silicon nanoparticles loaded with gold in three different types of breast cancer. The special silicon particles are the result of rigorous and meticulous research designed to develop nanoparticles that bind preferentially to breast cancer cells, compared to healthy cells of, for example, the liver or the immune system.

The research group found that the size and shape of the silicon particles, as well as their surface chemistry, all matter. If the silicon nanoparticles are too large or have a different shape, they may bind to several types of cells (and not just cancer cells), or to no cell at all. Polyamine molecules are bound to the silicon particles in order to improve their attraction to the surface of the cancer cells and increase their solubility in the body. The silicon nanoparticles have a diameter of one micrometer, while a typical cancer cell is ten times larger.

"The hollow gold particles that we inserted into the porous silicon particles must be the right size and at the right spacing between them in order to react to the infrared light we use," explains the researcher. "At the same time, it will be necessary to change the wavelength of the infrared light depending on the location of the tumor. If the tumor is close to the skin layer, we can use a lower wavelength. The more the tumor is inside the body, the more we will have to use a higher wavelength in order to penetrate and reach the tumor itself. Because of this, it will be necessary to change the space inside the gold particles depending on the location of the tumor."
Both gold and silicon have low toxicity profiles in the human body, and are popular materials in current research utilizing medical nanotechnology. Silicon is slowly broken down by physiological processes in the body into an acid that is removed from the body through the kidneys. The gold is an inert substance for the body.

Infrared radiation - of the type found in remote controls for televisions and remote controls for opening parking doors - is also less dangerous than radiation with lower wavelengths, such as ultraviolet, which can damage DNA, as well as X-rays.

The explanation for the discovered mechanism lies in the fact that the energy of certain wavelengths in the light spectrum are largely absorbed by the particles, and that this energy is emitted as heat energy. This absorption is affected both by the volume of the spaces found inside the hollow gold particles, and by the properties of the gold itself.

The lead researcher says that he was interested in finding out if this method could be used to eliminate entire tumors, and not just individual cancer cells. "We plan to conduct pre-clinical experiments to examine the effect of the technology on whole tumors, breast cancer cells and pancreatic cancer cells," says the researcher. "We would also like to examine whether this approach could improve the effectiveness of the chemotherapy method, that is - whether we could use a smaller amount of drugs in order to achieve the same level of success for the treatment of tumors. These studies are further down the road."

The news about the study

11 תגובות

  1. Depends on the poor observer
    Who knows what influenced Aharon, everything according to the books was magical, and difficult on the other hand, but it's not for nothing, after all
    Why were fruit trees placed in paradise if paradise is,
    There is a battle here that I will not detail my opinion at the moment between the instinct and the great God, because all human beings and the world are built
    About the course of this battle, for example: We have a beautiful, charming, and engrossing world, and I wish I could find the way
    to enjoy it and what it offers, most of the people are so engrossed in their lives and livelihood, or in the pursuit of something, that we forget that we have such a magical world
    A beautiful world, difficult to enjoy, Paradise and the fruits, Sodom and Lot, Noah and the destroyed generation, money and crime and more.
    The ten commandments are also divided, there is an influence on every living being from above if necessary for the sake of the process
    Example: where is Hitler hell or heaven
    Answer . If he fulfilled his role in causing the establishment of the State of Israel, then why the hell
    After all, there was no other way to wake up our people from their ambush,
    They even gave the Jews time to escape without their property. Many did not flee for reasons of convenience,
    The creature makes sure that you stay there and tell me it won't happen, the positive that sees the truth runs away

  2. Hello Meir,
    The scoring was invented many hundreds of years after the Bible was already signed.
    There were calves in the temples in Israel, as was the case in Solomon's temple in Jerusalem. As it is written explicitly [in the isolated spelling (not a full spelling) and without punctuation] in the book of XNUMX Kings, chapter XNUMX: verses XNUMX, XNUMX, XNUMX; Chapter XNUMX, verse XNUMX; Chapter XNUMX, verse XNUMX (which indeed speaks of the temples of Israel but mentions Jerusalem in this context) and in other places.
    But even without these references, let's think logically for a moment. Do you think it is likely that Aharon the High Priest will turn into a great and mighty god from just some young beast? I would give him a little more credit...

  3. Yuval Shalom
    I don't see a circular writing, I don't see a dot above the gimbal, and the scoring of the calf is accurate
    Regarding Egyptian mythology, I am not particularly knowledgeable, perhaps the reference is to the sun god, who is considered round,

    I don't know if it is possible to connect their sons, and everything is possible, don't forget that the Israelites in the desert were under the influence of the flu
    Egyptian beliefs, after 400 years in captivity do not expect too much,

    That's why God surrounded them for 40 years, almost 2 generations, and this in order to inculcate the belief in God 1,
    The Egyptians also had their own gods, but the snake ate their snake, and the Egyptians also admitted that our god is the strongest,

    Unfortunately, humans, including me, only make believe, and only after many beatings, such as the Israelites in the desert
    They fell for unbelief many times, until they straightened up, and not all of them, and even if there were miracles in front of them,

  4. Gold floating on the surface of the water? Maybe there is no light and heavy in the Torah?
    And did you give your mind to the trivia question? Round (in full spelling, round) and made of gold. The symbol of which god from Egyptian mythology is it?

  5. Pay attention to write
    Viser on the surface of the water = floating
    He both burned the gold and ground it finely
    Have you thought about how you can burn gold and grind it to a fine powder, and all this in order to plate it otherwise, what's the point of the whole process
    If the gold sinks, therefore the gold must be like a wreath on the surface of the water,

  6. Meyer,
    Gold is heavy and sinks in water. The people drank only the ashes. The gold deposit remained in the hands of the priests.
    And a trivia question: What is the shape of the golden calf and what is its color, and to which god from Egyptian mythology can it be attributed?

  7. the calf that they made, and it was burned in the fire, and it was ground, until it was fine; And he sprinkled upon the face of the waters, and watered the children of Israel.

    When Moses came down from the mountain, he was full of energy that could cause disease in humans, cancer, and more
    He shredded the gold into ashes and gave them to eat, some claim that it is the secret to the Mikve immune system
    Very much, he noticed that before he let them eat, he wetted the gold, which means that the gold has to be absorbed by the body
    with the help of minerals

  8. What about re-induction of ErbB-2?
    This will cause the cancer to return, regardless of whether the source has been destroyed.
    After all, breast cancer is caused by various reasons..

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