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Vitamin D deficiency may lead to an increase in mortality among corona patients

It appears fromA joint study by the Faculty of Medicine of Bar-Ilan University and the Galilee Medical Center. According to the researchers, vitamin D plays an important role in the immune response to respiratory diseases

Dr. Amiel Dror, Bar Ilan University. Photo: Tomesh Solinsky
Dr. Amiel Dror, Bar Ilan University. Photography: Tomesh Solinsky

Vitamin D is often recognized as essential for bone health, but a variety of autoimmune, cardiovascular and infectious diseases have been linked to low levels of the supplement in the body. In October 2020, the Ministry of Health published guidelines for the consumption of vitamin D that can be found on Google "Vitamin D and Corona guidelines for the public and caregivers" in order to encourage people to take vitamin D, because it plays a role in strengthening the immune response and can protect against the corona virus. It is estimated that vitamin D deficiency exists among 70% of the population in Israel.  The study was led by Dr. Amiel Dror and Prof. Michael Edelstein from the Faculty of Medicine of Bar-Ilan University and the Galilee Medical Center, along with Dr. Amir Bashkin, the director of the endocrinology unit at the hospital.

In a study published today in the journal PLoS ONE The researchers from the Azrieli Faculty of Medicine at Bar-Ilan University and the Galilee Medical Center in Nahariya show a clear correlation between vitamin D deficiency and the severity and mortality rate of COVID-19.

The study is among the first to analyze vitamin D levels that were measured weeks to months before infection with the virus, and were found to be a predictive factor for the severity of the corona disease among hospitalized patients.

The findings reported today are based on results first published inMedRxiv.

In the records of 1,176 patients hospitalized between April 2020 and February 2021 at the Galilee Medical Center (GMC) with positive PCR tests, vitamin D levels measured two to two years before infection were examined.

Hospitalized patients with vitamin D deficiency (less than 20 ng/ml) were 14 times more likely to have severe or critical illness from the coronavirus compared to those with more than 40 ng/ml.

Surprisingly, the mortality rate among patients with sufficient levels of vitamin D was 2.3%, in contrast to a mortality rate of 25.6% in the vitamin D deficient group.

The study was adjusted for age, weight, background diseases, and the season of the year in which the subjects fell ill, and in all cases it was found that vitamin D is statistically significantly related to the severity of the disease and even mortality, independently of all the other factors tested in a multivariable model.

"Our results indicate that it is recommended to consistently monitor and maintain normal levels of vitamin D. This will benefit those infected with the virus," says Dr. Amiel Dror, from the Galilee Medical Center and the Faculty of Medicine of Bar-Ilan University, who led the study. Even on normal days, there is a recommendation by health organizations in Israel and around the world to take a vitamin D supplement on a daily basis depending on age and weight." Dr. Amir Bashkin, director of the endocrinology unit at the hospital who participated in the study added, "This is especially true during the corona epidemic when vitamin D plays an important role in the immune response to respiratory diseases", at the same time it is important to avoid excessive consumption of vitamin D and it is recommended to consume according to the guidelines of Ministry of Health. This study contributes to the ever-evolving body of evidence, which indicates that a history of vitamin D deficiency in the patient is a predictive risk factor associated with poor course of the clinical disease and mortality," said research partner Prof. Michael Edelstein from the Azrieli Faculty of Medicine at Bar-Ilan University. "It is still unclear why some people suffer severe consequences from the coronavirus while others do not. Our finding adds a new dimension to solving this puzzle."

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3 תגובות

  1. Good morning Eliyahu. We've been talking about this for years, it's unbelievable, wow everyone knows this hahahaha

  2. A note about an adapter. There are two places where Mitham is reported without specifying his direction. Although there is an explanation later, it is better to be precise from the beginning.

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