Innovative results from a European Union research project headed by Prof. Avidan Neuman from the Faculty of Life Sciences at Bar-Ilan University were presented at the conference of the "American Association for the Study of Liver Diseases" in Boston, USA
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Predicting the response to the standard hepatitis C treatment is possible from the first week of treatment. Innovative results from a European Union research project headed by Prof. Avidan Neuman from the Faculty of Life Sciences at Bar-Ilan University were presented at the "American Association for the Study of Liver Diseases" conference in Boston, USA.
The currently accepted treatment for hepatitis C is prolonged, has side effects for the patient, is expensive for the system and its success is limited. It is therefore of great importance to predict as early and accurately as possible which patients will not respond to treatment.
The use of the method presented in this study makes it possible to predict the patient's response already after 1-4 weeks of treatment compared to 12 weeks in the currently accepted method. Also, already at this early stage it is possible to accurately identify a larger part (2 times) of the patients who will not respond to treatment.
This is the first major clinical study in which bio-mathematical dynamic models are used in real time, with the aim of adapting the treatment personally to each patient. The bio-mathematical model used in the research is based on the viral dynamics model of HCV published by Prof. Neumann in the journal Science in 1998.
Prof. Avidan Neuman, head of the laboratory for biomathematical models in viral dynamics at Bar-Ilan University, began the research in collaboration with four leading researchers in the field of viral hepatitis
Type C, HCV from Europe. Currently, 13 clinical and scientific centers are participating in this study, which is supported by the European Union.
In the study, 270 HCV patients were treated, from 9 European countries, including 35 patients from Israel who were treated by Dr. Yoav Luria from the Liver Clinic at the Sourasky Medical Center in Tel Aviv (Ichilov Hospital).
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