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Molecular biology of the cell

Mouse, rabbit and human embryos (right to left) in the same developmental stage - gastrulation (days 8-7.5 of pregnancy in rabbits and mice and around day 18 of development in humans). At this stage the human, rabbit and other vertebrate embryos are almost flat disc-shaped, while the mouse embryo is elongated cylinder-shaped. The images of the mouse and rabbit embryos were created as part of the current study, the image of the human embryo is taken from a study published in 2021 (Richard CV Tyser et al. Single-cell transcriptomic characterization of a gastrulating human embryo. Nature 600: 285-289)

In the rabbit hole

The institute's scientists developed a method that allows real-time monitoring of the development of embryos at the beginning of their journey and applied it for the first time to rabbits. The comparison they made between embryonic development in rabbits and mice gave rise to answers to fascinating questions about the formation of humans
The pituitary gland of the zebrafish. The variety of cell types are marked in different colors: in purple - phytocytes, in red and green - two types of hormone-producing cells

Where does the fish secrete from: back to the origins of the pituitary gland

Weizmann Institute scientists are challenging a 200-year-old doctrine about the formation of the gland from the secretion of hormones. Their findings may lead to new approaches in the treatment of various medical problems
Cancer treatment. Illustration: depositphotos.com

Break the boundaries of immunotherapy

The method that may make the new generation of cancer treatments accessible to more patients
the lungs. From jumpstory

A new approach to personalized cancer medicine: listening to the internal messages inside the tumor cells

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Bacteria (in green) establish a home in cancer cells and settle comfortably in the cell nucleus area. Source: Weizmann Institute

Cell within a cell: the bacteria that live inside cancerous tumors

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Autoimmune diseases of specific organs are manifested, among others, in the thyroid gland, the adrenal gland, and the beta cells in the pancreas. Why does the immune system attack these organs and not others? Illustration Prof. Uri Alon, Weizmann Institute

What causes autoimmune diseases?

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Cancer cell genome. Illustration: shutterstock

Biomarkers that may predict the chances of success of cancer immunotherapy

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Gestational diabetes. Illustration: shutterstock

An algorithm will allow early identification of the risk of developing gestational diabetes

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Dr. Itai Tirosh and Julie Lafi. The most common and violent brain cancer

Against four cells - why is there currently no effective drug for the treatment of glioblastoma brain cancer?

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Skin cancer (melanoma). From Wikipedia

The chances of success of immunotherapy depend on the degree of heterogeneity of the cancer tumor

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Diagram of the spatial interaction between the DNA control regions and the controlled genes. The "reporters" (in red and green) reveal these interactions. The laboratory of Dr. Yonatan Stanzler, Weizmann Institute

A cell following its fate

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The hormone oxytocin (in purple) at the secretion points in the synapses (in green) in the transparent brain of a genetically modified zebrafish. Prof. Gil Levkovitch, Weizmann Institute

the love bubble

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Transient aging: Zebrafish (top row), newborn mouse (middle row) and adult mouse (bottom row) hearts are seen (left column) with almost no senescent fibroblasts (indicated in turquoise). After injury to the heart muscle (accompanying agrin injections in an adult mouse), many fibroblasts went into a state of senescence (middle column), which passed about three weeks later (right column)

Aging cells, young heart

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Image 1: E.coli bacteria at 10,000x magnification. Image source: Agricultural Research Service, via Wikipedia.

Same bacteria - different effect

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Arabidopsis_thaliana From Wikipedia

The eyes of the plants

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The triumvirate of the neurohypophysis: phytocytes (in purple) scattered between the ends of axons (in green) and blood capillaries (in red)

Discovery: how certain blood vessels in the brain open "windows" that allow overcoming the blood-brain barrier

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A significant decrease in the number of senescent cells (blue spots) in the liver and lung tissues of mice following the drug treatment

Forever young - the lab version

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Two endothelial cells in the liver. The cell on the right expresses high levels of the Wnt2 gene (red), and the cell on the left - high levels of the Dkk3 gene, which suppresses Wnt (green)

Friend brings a friend

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T cells of the immune system (in red) attack melanoma cancer cells (in green). T cells that "know" how to read "signposts" on the cancer cells are particularly effective in destroying them. Illustration: Prof. Jordana Samuels, Weizmann Institute

Towards personalized treatment of melanoma skin cancer

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Close-up of a zebrafish eye. A sophisticated and accurate vision system

A look at the fish's eye

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Breast cancer cells in culture as seen under an optical microscope. You can see the bands connecting the cells. Photo: Prof. Geiger, Weizmann Institute

All together and each separately

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Cells. Illustration: shutterstock

The genetic internet

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Calcium carbonate walls that protect a bacterial colony. Illustration: Weizmann Institute

Break down walls - and heal

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Neurons communicate with each other. Illustration: shutterstock

The protein will react at the appropriate time and place

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Nose. Illustration: Spokesperson of the Weizmann Institute

Scientists at the Weizmann Institute of Science inserted a miniature "nose" into a living cell

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