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Alzheimer's

A fitness pill. Credit: The Science website via DALEE

New 'workout pill' can cause fitness benefits without exercise

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Researchers report new compounds that appear to be able to mimic the physical drive of exercise—at least in rodent cells. This discovery could lead to a new way to treat muscular dystrophy and other medical conditions in humans, including heart failure and neurodegenerative diseases
Brain diseases. Illustration: depositphotos.com

Neurological morbidity is the world's number 1 cause of morbidity and disability, with over 3 billion people with brain diseases

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Neurological morbidity is the world's number 1 cause of morbidity and disability, with over 3 billion people with brain diseases * according to an article published this weekend in the Lancet. The scope of morbidity and disability has grown since 1990 by 18%
scientific picture. A XNUMXD model system of human neurons in a dish. In green and purple: nerve cells expressing a protein that is defective in the ubiquitin system. As a result of this expression, the pathology that characterizes Alzheimer's patients is created - the formation of amyloid clusters (in red) outside the cells

Technion researchers have identified the mechanism leading to the formation of protein aggregates involved in the development of Alzheimer's disease

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Toxic proteins accumulate in the brains of Alzheimer's patients. In the familial Alzheimer's patients, the accumulation mechanism is clear since there is a circumstantial relationship between the mutations and the identity of the defective proteins. In the random disease, on the other hand, the reason for the accumulation of the defective proteins was unknown
Left: cells with a mutant FUS protein that causes accumulations (in green) and leads to ALS disease. Right: the cells with the protein/chaferon (in pink) that manages to prevent the accumulations

fight degenerative diseases

The proteins and mechanisms required to fight the protein accumulations that lead to neurodegenerative diseases have been identified
Personalized Medicine Illustrated: depositphotos.com

The discovery that will advance personalized medicine for infectious diseases

This is the first time that researchers succeed in developing personalized tools for infectious diseases, which until now have only been developed for specific diseases such as cancer and Alzheimer's
Microglial cells (in green) in the hippocampus region of the brain of an adult mouse, forming contact points with a new neuron (in red)

The biology of depression

Degeneration of the cells of the immune system in the brain may be the biological cause of depression, and there may be substances that can restore these cells - and be antidepressants
Prof. Hermona Sorek (right). Photo: Yosef Edst, courtesy of the Hebrew University

Breakthrough in Alzheimer's research among women

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Professor Hermona Sorek, one of the world's leading researchers of gene expression in the brain, was able to find, in collaboration with her research colleagues, a molecular mechanism that occurs in the brains of Alzheimer's patients, which does not occur in men and which explains the acceleration of cognitive deterioration in Alzheimer's patients
Prof. Michal Schwartz. Photo: Weizmann Institute Spokesperson

Prof. Michal Schwartz from the Weizmann Institute won the Israel Prize for research on the relationship between the immune system and the nervous system

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Prof. Schwartz challenged the convention that nerve cells do not regenerate or recover, and discovered that the immune system also takes care of them. She also studied the blood-brain barrier and discovered that it prevents the cells of the immune system from helping in cases of brain damage such as Alzheimer's
Link to the figure with a diagram showing the pathophysiological changes of Alzheimer's disease which the VBIT-4 molecule prevents by binding to the VDAC1 protein

A new approach to treating Alzheimer's

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The research carried out at Ben Gurion University focused on the VDAC1 protein that controls mitochondrial activity and controls cell life and death
John McCarthy, Head of Life Sciences and Health at Dassault Systèmes. Photo: Avi Blizovsky

The target is the brain

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The living brain project of Dassault Systèmes makes it possible to develop treatments for epilepsy patients who do not respond to drugs, says John McCarthy, head of life sciences and health at Dassault Systèmes in an interview with the science website at the CES conference
The beta amyloid protein. Image: depositphotos.com

Alzheimer's theory undermined by allegations of manipulated data - but does not bring dementia research to its knees

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A seminal 2006 article in Nature claiming that beta-amyloid protein was the main cause of Alzheimer's was found to be partially fabricated. Long years of attempts to develop medicines were lost in vain * Twenty more articles by the same author are now being examined
The Alzheimer's conundrum. Illustration: depositphotos.com

The balance point - on the way to understanding Alzheimer's disease

Disruption of the activity rate of neural networks is related to the development of Alzheimer's disease
differences between the sexes. Illustration: depositphotos.com

Differences between the sexes - the worm version

Recently, Weizmann Institute of Science scientists compared neural networks of female and male worms, and discovered a molecular mechanism that may explain how differences between the sexes in neurological diseases in humans arise
neurological diseases. Illustration: shutterstock

A new mechanism for the development of Alzheimer's and Parkinson's

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Imaging of communication between two cells of the immune system - a "combatant" T cell and a "suppressor" myeloid cell. The yellow sparks are meant to illustrate intracellular processes that can be detected using the new method

New technology allows a "peek" into what is happening inside cells

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Prof. Ilana Gozes. Photo: Tel Aviv University

An experimental Alzheimer's drug may help children with autism

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Alzheimer's. Illustration: Image by Gerd Altmann from Pixabay

Researchers at Tel Aviv University: many genetic mutations that characterize autism and intellectual disability also appear in the brains of Alzheimer's patients

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The cover image in Small magazine, dedicated to research. The silicon chips are inserted into the mouse's brain by safe implantation or by means of a gene gun. The chips break down while releasing nerve growth factor, a protein that prevents the death of nerve cells in Alzheimer's disease

Researchers at the Technion and Bar Ilan University have developed a new technology for transporting drugs to the brain inside silicon chips with a nanometer structure

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The new inhibitor (in purple) that the researchers discovered binds with extraordinary efficiency to the MKK7 protein from the kinase group (in gray). Courtesy of Prof. Nir London, Weizmann Institute

Cellular censorship

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the brain. Illustration from PIXABAY.COM

A team of researchers from Belgium received a million dollars from the Chan Zuckerberg Foundation to develop a chip that will interface with the brain

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Fluorite crystal - the mineral is mentioned in writings from the 16th century, is used, among other things, for ornamental purposes and is considered one of the most colorful minerals in the world. Photo: Rob Lavinsky, iRocks.com – CC-BY-SA-3.0

What does the crystal signify?

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I will produce. Illustration from PIXABAY.COM

Gene therapy may cure Alzheimer's

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Alzheimer's. Illustration - from pixabay.com

Does disruption of blood flow to the brain cause Alzheimer?

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The discovery will make it possible to treat a series of diseases that arise as a result of the accumulation of proteins in cells. Illustration: pixabay.

Researchers have identified a biological mechanism for breaking down protein clumps

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Illustration of a pressure chamber at Assaf Harofeh Medical Center. Credit: Tamir Noi, courtesy of Tel Aviv University.

Pressure chamber treatment resulted in significant improvement in mice with Alzheimer's

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