Researchers from the Hadassah Ein-Karem University Hospital report that embryonic stem cells, transplanted into the brains of mice with multiple sclerosis, significantly reduced the clinical and pathological symptoms of the disease
Multiple sclerosis is the most common cause of neurological disabilities in young people. It is an autoimmune inflammatory disease of the central nervous system, in which the immune system attacks the nerve sheath proteins in the brain (myelin). As a result, the nervous system is damaged on several levels and functional impairment is caused in several neurological systems: sensation, motor skills, balance, the sphincter system and vision.
While the accepted and main goal of stem cell transplantation is to renew the pool of myelin-producing cells and the envelopes of the nerve cells in the brain, this time the use of the stem cells was done with the aim of suppressing the inflammation. In this study, neural stem cells derived from embryonic stem cells were transplanted into the brains of mice with multiple sclerosis. The transplanted human cells merged in the brains of the mice and migrated towards the foci of inflammation. The cell transplantation suppressed and reduced the inflammatory process in the brain and thereby protected the animals from major damage to the myelin and nerve fibers, which are the pathological hallmark of multiple sclerosis. At the same time, the signs of the disease were significantly reduced in the transplanted animals. The results of the study were published in early September 2008 in the scientific journal PLoS ONE.
The research is the result of a long-term collaboration between Prof. Tamir Ben-Hur, director of the neurology department and Prof. Binyamin Raubinoff, director of the Center for Fetal Stem Cell Research at Hadassah. Also, Michal Aharonovich and Dr. Ofira Einstein from Hadassah and Prof. Hans Lassmann from the University of Vienna participated in the study. The researchers believe that the encouraging effects on the course of the disease obtained in animal transplantation will pave the way for further developments towards clinical trials. In addition, the researchers anticipate that the effect of transplantation on the suppression of inflammation, demonstrated in this study, will be combined in the future with the use of embryonic stem cells for the purpose of repairing and renewing the myelin in the brain.
The Selcure company, which is a subsidiary of Hadassat (Hadassa's technological application arm), will promote the application of the findings of this research towards the clinical trial phase, which is planned to begin in about three years. "Selcure" specializes in the development of embryonic stem cells for the treatment of neurodegenerative diseases of the nervous system.
The research work was partially funded by the National Science Foundation and a licensed foundation.
8 תגובות
March:
We forgave!
Sorry? Why are they called "father" cells?! and no "if" cells
"cell therapy" (cell therapy in mature autologous stem cells, (ASC)
A breakthrough in curing serious diseases
To date, two types of stem cells have been isolated:
(1) Embryonic stem cells (ESC), which originate from early embryos about 5 days old, and are pluripotent - capable of developing into any of the 200 different types of cells that make up the body.
(2) Adult stem cells (ASC), are found in various tissues of the adult body as well as in umbilical cord blood, and are multipotent - able to become part of the body's cell types.
The differentiated stem cells are able to migrate to the tissue they differentiated into, in a process called "homing". Embryonic stem cells have the most flexibility to differentiate into different tissues and this flexibility decreases as the source of the stem cells is older. However, the use of embryonic stem cells involves ethical problems.
The treatment with the help of stem cells is defined as "cell therapy" that allows you to stay in the body for a long time, thus they help in long-term healing. Cellular treatments are one of the great hopes of modern medicine, and this treatment includes renewal, repair and replacement of organs and tissues.
Cell therapy is a part of personal therapy in which autologous stem cells are used that are isolated from the patient himself, undergo processes of cloning, differentiation, gene insertion, etc., and are returned to the patient to correct diseases. Using autologous cells will prevent their rejection by the body's immune system.
The biomedical research in stem cells includes:
Organ transplants - restoration of vital functions of the body with the help of stem cells, gene therapy - introducing genes into certain tissues of the body with the help of stem cells, "therapeutic cloning" - a method in which the ability to divide as stem cells can be restored to a person's adult cells in order to grow replacement tissues genetically identical to the patient, and basic research on fetal development, chromosomal changes that cause birth defects and cancer, and more.
Stem cells are currently used for medical treatments:
Bone marrow transplantation from stem cells derived from peripheral blood and umbilical cord blood is a routine procedure for more than sixty different diseases (cancer, genetic, immune, metabolic, autoimmune and more). In addition, experimental stem cell treatments are already being conducted in humans for tissue engineering in diseases such as diabetes, lupus, multiple sclerosis, heart disease, heart failure, liver disease, blood vessel disease, central nervous system cells, eye disease, ear disease, damage In the spine, muscle diseases, bone tissue, Alzheimer's, Parkinson's, treatment of necrosis and damaged cartilage and more. The understandings and abilities on the issue of stem cells are getting more and more advanced in the world, and after the settlement of the political, scientific and ethical issues, it is clear today that
Dealing with the issue of stem cells is a decisive moment for the human race.
And to every sick person for prevention, healing and recovery.
The instigator will produce autologous stem cells to cure various diseases, including diseases that are considered incurable
introduction
Following on from the article on adult autologous stem cells (ESC) this article reviews a number of articles that appeared on the Internet on the healing and rehabilitation capabilities of various diseases of treatment with adult autologous stem cells (ESC). From the professional literature, testimonies and experiences of people in Israel and the USA, it seems that treatment with stem cells Adult autologous cells (ESC) have a healing capacity that has not been found so far with regard to any other treatment in the world. However, it is impossible to expect that a person will be cured of any disease with only this treatment.
In cases of diseases that are difficult to cure, it is very important to adopt this option of treatment with the help of adult autologous stem cells (ESC), and this together with a comprehensive natural health care that will integrate proper nutrition, super nutrition, medicinal plants, edible plants, wild edible plants and supplementing deficiencies and the necessary food supplements For each person according to his physical and mental health condition and age.
The uniqueness of mature autonomous stem cells (ESC)
It is their ability to reach different parts of the body that have been damaged, from disease or accident and injury, and to transform there into the cells of that damaged tissue and organ. Most of the stem cells are created and stored in the bone marrow, where they divide and multiply themselves.
Our blood vessels are damaged every day and every day they need to be repaired. This damage, done to the inner coating layer of the arteries, the epithelium, is caused by oxidized cholesterol, fats, sugar, high blood pressure and more. This is how phenomena such as calcification of arteries, heart disease, stroke and other diseases develop in the body.
In health and natural self-healing there are ways to reduce cholesterol levels, reduce its oxidation through the consumption of food on a proper diet, antioxidant food supplements and a number of herbs with a similar action. There are products like enzymes, which break down any dead protein in the body, without side effects. But, when damage occurs, the ones who can repair it are the body's own stem cells, which are released from the bone marrow, flow in the blood to the target organs and repair the damaged tissues. As a person ages, fewer stem cells are released from their bone marrow. There is less repair of injuries in the body, advanced aging processes and eventually the person dies.
Treatment with mature autologous stem cells (ESC) has been shown to help treat damage from heart attacks and congestive heart failure. Such treatment, by injecting stem cells into a damaged heart, is done in hospitals in Bangkok and Singapore. In such a treatment, a 200 cc blood portion is taken from the person, the stem cells are separated from it and multiplied for 8 days. After that, they are returned to the damaged place, by injection or minimal surgery. Once injected into the injury site, the stem cells transform themselves into the cells of the same damaged tissue and repair what was damaged in it. But, there is another, simpler, cheaper and more practical way. This way is to increase the release of one's own autologous stem cells. Although there are cases where the first method presented here yields results in a shorter time, it is much more expensive and difficult to perform and is not suitable for every patient.
An article in the newspaper Regenerative News focused on the treatment of osteoarthritis, a degenerative disease of the joints. This is one of the more common diseases in middle age and old age, with the pain and disabilities it causes. The main cause of this disease is not only wear and tear of the cartilage and bones in the joints, but also the inability of the body to repair such injuries. This happens because of the reduction that occurs with age in the creation and release of the body's own stem cells. Any way that increases the production and release of stem cells will contribute to the prevention as well as the cure of osteoarthritis. To date, the only treatments have been surgical treatments. Now there is a possibility, with taking the unique food supplement of mature autologous stem cells, to activate internal reconstruction of the cartilages as well as the damaged bones. This is a major innovative treatment, but it must be combined with any other nutritional or rehabilitative treatment from those found to contribute to the relief of the symptoms of this disease. This is a proven and safe treatment, unlike treatment with embryonic stem cells which in some cases may cause the development of a cancerous tumor. This is about restoring and increasing the body's own natural processes.
In an experiment with animals, which were injected with millions of stem cells from the marrow of their own bones into the damaged knees that had previously had osteoarthritis, it was found that after the injection of the stem cells, a significant restoration of the medial meniscus (the middle crescent) began in their knees. The cells transplanted there multiplied considerably and restored the cartilage. Healing began only in those animals that received the treatment with stem cells, not with the placebo. Treatments done with humans, either by injecting autologous stem cells or increasing their autologous release, have shown similar benefit. Such treatments with autologous stem cell injection have been approved by the FDA and the American Medical Association. As for the adult autologous stem cell food supplement, it has been approved by the FDA as a food supplement.
Treatments with mature autologous stem cells (ESC), either by multiplying them and returning them to the body, or by taking the food supplement, have been found to help cure a long list of many different diseases. As for some of them, they currently have no other treatment. A list of diseases will be given here as it appeared on the Internet and it was recorded here as it is, without adding or subtracting. This list has been translated into Hebrew and appears in alphabetical order of the names of the diseases in English.
Diseases in which Stamanhans, which increases the release of autologous stem cells, has helped
1. ALS, muscular dystrophy, Lou Gehrig's disease.
2. Alzheimer's disease
3. Anemia, beta thalassemia, sickle cell anemia, hemoglobin diseases.
4. Angina.
5. Arthritis, gout, inflammation of the jaw (tendonitis).
6. Autoimmune diseases such as scleroderma, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus.
7. Back pain.
8. Building bones, cartilages, ligaments and tendons, artery surgery, carpal tunnel syndrome, mandibular repair.
9. Brain ischemia, stroke.
10. Breast cancer, generalized breast cancer.
11. Burns.
12. Solid cancers, blood cancers, multiple myeloma, myelogenous leukemia, brain tumor, bone cancer, lung cancer, eye cancer, cancer pain, rehabilitation after surgery.
13. Chronic multigranulocyte disease.
14. Platform.
15. Cystic fibrosis.
16. Diabetes (chronic, non-healing wounds).
17. Degenerative diseases of spinal discs.
18. Eye diseases of the cornea, ocular surface, ocular surface reconstruction, conjunctivitis, limbal epithelium.
19. Fetal diseases.
20. Heart diseases such as heart failure, congestive heart failure, myocardial leakage, valve activity, cardiomyopathy (severe ischemia), myocardial infarction, post-myocardial infarction aneurysm.
21 Hernia repair.
22. HIV.
23. Huntington's disease.
24. Knee rehabilitation.
25. Disorders in the production of white blood cells.
26. Acute, chronic myelogenous leukemia, AML.
27. Liver diseases such as hepatitis and liver cirrhosis (cirrhosis).
28. Lupus and severe lupus of its types.
29. Non-Hodgkins lymphoma.
30. Metabolic syndrome.
31. Multiple sclerosis.
32. Muscle rehabilitation.
33. Duchenne's disease, apoulohumeral paciusak muscular dystrophy.
34. Myelogyplastic syndrome.
35. Neuroblastoma.
36. Neurometabolic diseases.
37. Rehabilitation of the nervous system, rehabilitation of peripheral nerves.
38. Organ failure, organ rehabilitation AL amyloidosis.
39. Osteoporosis.
40. PAOD, peripheral arterial occlusion disease.
41. Parkinson's disease.
42. Nonpromyelukitis of children AML.
43. Plastic surgeries, general tissue restoration.
44. POEMS syndrome.
45. Damage from funds.
46. Retinoplasty.
47. Rehabilitation of salivary glands.
48. Sarcoma.
49. Scleroderma, systemic sclerosis, systemic cutaneous sclerosis, scleromyxedema.
50. Sjögren's disease.
51. Repairing skeletal injuries.
52. Skin diseases and skin wounds.
53. Dental restoration.
54. Damage to the spinal cord.
55. Periodontal restoration of the teeth, osteointegration and dental implantation.
56. Urology.
57. Healing wounds.
This list was written by Dr. David A Steenblock, USA
Testimonies of those who recover and are cured using the "autologous stem cells" capsules
And since the FDA, the Food and Drug Administration in the USA, as well as the authorities in the State of Israel, do not allow attributing healing properties to food supplements, there is no clarification left, but only the possibility of bringing personal stories and successes of recoverers who were helped with the use of the food supplement "autologous stem cells" for the purpose of healing and improving their health.
In this article we bring things in the name of Omram
Yes Ami and now the brain is also healthier
Nice progress, it really makes you feel good to hear about such progress made in Israel.
It is beautiful to see that such groundbreaking and practical science begins in the Land of Israel. We have the brain - now we need someone to invest.