Medicines

The residents of Easter Island did not receive a penny from the medicine discovered in their country. Illustration: depositphotos.com

A drug worth billions was discovered on Easter Island – but the healers were left out of the story

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Rapamycin, one of the most important drugs in modern medicine, was discovered in soil collected by a medical expedition in 1964 – but the indigenous people received no credit or compensation.
Tylenol. Illustration: depositphotos.com

Trump warns against using Tylenol during pregnancy and promotes new autism drug – Medical community: No conclusive evidence

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President Trump has declared that acetaminophen, the active ingredient in Tylenol (paracetamol), may increase the risk of autism in pregnancy, and has promoted the use of leucovorin as an experimental treatment. Researchers and medical associations emphasize: There is no evidence of causation, Tylenol is considered
Dr. Noa Shankar dives to investigate stone corals in the Gulf of Eilat. Photo: Tel Aviv University

Antibiotics and laxatives - in corals at a depth of 40 meters

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Elimination of lymphoma cells in mice. Courtesy of the researchers

focus on the goal

Researchers created a composition of nanoparticles that was able to destroy lymphoma cells in mice
drug development. Illustration: depositphotos.com

New insights into polymorphisms could influence drug development

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Researchers have used a variety of methods in order to reveal the different polymorphs that can be prepared from a common crystalline material and the paths of conversion of one configuration to another depending on the temperature and the method of preparation
The illustration is courtesy of Medidata

Medidata opens access to its Patient Insights Program to research organizations

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This is a system that allows research organizations to leverage the Patient Centricity by Design process to plan clinical trials, among other things to be able to follow the patients who participated in the clinical trials after the trial
Pharmaceutical factory. Illustration: depositphotos.com

Dassault Systèmes collaborates with Sanofi in the planning and optimization of pharmaceutical factories

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Sanofi will build a factory in virtual space that will operate during an epidemic and produce vaccines to accelerate the development of vaccines
mRNA. Illustration: depositphotos.com

Moderna and IBM will investigate the development of mRNA-based therapies with the help of quantum computing and artificial intelligence

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As part of the collaboration, IBM will provide modern scientists with access to quantum computing systems, and they will learn how quantum computing technologies can be applied to problems that were previously intractable for classical computers.
The type of side chain affects the anchoring ability of the ring peptide to the cell membrane. Stephanie M. Linker et al. Journal of Medicinal Chemistry 2023 66 (4), 2773-2788

How drugs enter the blood

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First, the molecule anchors itself to the surface of the membrane, before it penetrates the membrane in a direction perpendicular to it. In the next step it changes its 3D structure as it passes through the membrane, rotating once
when age Photography: Elad Malka

AION Labs is establishing the startup DenovAI that will deal with the design of antibodies and drugs

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DenovAI will combine machine learning and computational biophysics to discover antibodies with a wider scope, faster and cheaper, and to improve the probability of success of drug candidates. This is the second company established on
The macrocyclic compound P6AS can trap a variety of drugs that can cause overdose, including opioids, hallucinogens and stimulants, thanks to a hydrophobic internal niche. [Courtesy: © Brockett et al., Chem 9, 1–20 April 13, 2022 Elsevier Inc]

A molecular trap capable of trapping drugs after overdoses

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An innovative macroring material can trap a variety of drugs in overdose cases, including opioids, hallucinogens and stimulants, thanks to its hydrophobic niche
Technion researchers with Pfizer Chairman and CEO Dr. Albert Borla. From right to left: Dr. Uri Shalit, Dr. Dvir Aran, Prof. Shai Shen-Or, Dr. Albert Borla, Prof. Tomer Shlomi and Dr. R. Nega Ron-Harel Photo credit: Nitzan Zohar, Technion spokespeople

The Technion and Pfizer signed a cooperation agreement to accelerate scientific breakthroughs through artificial intelligence

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The Technion recently launched Tech.AI, a center that consolidates the Technion's biomed activity in the field of AI and makes research and application at the forefront of AI accessible to researchers from all units at the Technion
From right to left - Itai Katzir and Der Ila Lampal. Tel Aviv University spokeswoman photo

New technology will allow the isolation of many molecules in a single storage cell and their release through exposure to UV radiation

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The researchers estimate that the development will advance the construction of systems for storing biomolecules and drugs and their efficient and controlled release when needed by external stimulation, using light
Prof. Yosef Shaul. The virus ignited his imagination

FDA approval for a third generation vaccine for viral hepatitis B

The component was developed based on the research of Prof. Yosef Shaul
A clinical trial from the patient's perspective. Illustration: depositphotos.com

Designing clinical trials with a patient-oriented approach

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Medidata opens access to its Patient Insights Program, enabling research organizations to leverage the Patient Centricity by Design process to plan clinical trials
Illustration: depositphotos.com

The innovation laboratory AION Labs, with the support of BioMed X, publishes a first call for the discovery of therapeutic antibodies using artificial intelligence

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AION Labs, the Israeli innovation laboratory of AstraZeneca, Merck, Pfizer, Teva, Israel Biotech Fund and Amazon Web Services (AWS), is launching a first procedure to create a new venture based on the innovation model of
Mati Gil and Yair Benita, ALON LABS. Photography: Elad Malka

A laboratory was launched for the use of AI for drug development in collaboration with Pfizer, Teva, AstraZeneca, Merck and Amazon

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AION Labs unites the pharma companies, technology and foundations including IBF to invest in the start-up companies to integrate the developments in the field of cloud computing and artificial intelligence to improve the ability to develop medicines
clinical trial. Illustration: depositphotos.com

Medidata Adjudicate A unified solution for examining clinical endpoints

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A uniform digital solution for all endpoints of clinical trials, integrated with the Medidata Clinical Cloud
Medicines. Image: depositphotos.com

Many find it difficult to swallow medicines because of their repulsive taste - will a new method make them friendlier to humans?

Clinical Trials. Image: depositphotos.com

Medidata will help manage the clinical studies of the pharmaceutical company Horizon

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Horizon will access a wide range of clinical trial solutions through the Medidata Rave Clinical Cloud platform, to accelerate clinical research through a suite of applications that includes data collection and management, trial design and management
Fungal infection. Illustration: shutterstock

The European Research Council (ERC) will grant approximately 10 million euros to researchers from Tel Aviv University and the Charita University of Medicine Berlin

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The goal of the research is to lead to the development of antifungal drugs and combined treatments that will be effective against life-threatening invasive fungal infections
fire Currently approved for the treatment of prostate cancer patients in early stages in Europe, Mexico and Israel

New light on "Toked"

Follow-up using a new imaging method, changes were discovered that lead to the eradication of the tumor in a selective manner and without damage to the adjacent tissues
Teva and the Technion announce a collaboration to promote innovative research and development in the fields of cancer and the brain. PR photo

Teva and the Technion announce a collaboration to promote research and development in the fields of cancer and the brain

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drug search. From Jumpstory.com

Britain and Switzerland have joined the consortium led by IBM to accelerate research to find a vaccine and a cure for the corona virus

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Introducing a "prodrug" into the body. From the scientific article. Courtesy of the Weizmann Institute

Trojan drug

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The corona virus. Illustration: Jumpstory.com

Your computer can help scientists find a treatment for Corona

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Bacterial resistance to antibiotics. Illustration: shutterstock

Artificial intelligence has discovered a surprising new antibiotic

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From right to left: Prof. Itai Benhar, Almog Biton and Prof. Ariel Munitz. Courtesy of Tel Aviv University

Researchers in Tel Aviv discovered a central mechanism that causes "asthma of the skin"

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Artist's rendering of a macroring binding to a target protein (image courtesy: University of Basel, Basilius Sauter | CC BY-SA 3.0)

Learning from nature - new substances for use as medicines

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Structure of a protein molecule. Illustration: shutterstock

Protein: advantage and disadvantage

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The value chain in drug discovery. Illustration: shutterstock

An innovative method for converting hydrogen atoms into fluorine atoms for the production of more effective drugs

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the liver Image: Shutterstock

27 new molecules with extensive medicinal potential were discovered with the help of a groundbreaking algorithm

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A platform for the development of accessible drugs for rare genetic metabolic diseases

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The species Candida albicans at a magnification of 200 times. From Wikipedia

Researchers at the Faculty of Biotechnology and Food Engineering at the Technion cured fungal skin infections using a tiny "bacterial factory"

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The preparation of the platform (polymeric micelles) for transporting the tyrosine kinase inhibitor, marked with blue spheres. Illustration: Prof. Alejandro Sosnik, and Alex Bookchin. The Technion

A nanometer system for transporting drugs to treat children with cancer

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Chiral molecules. Photo courtesy of Yossi Peltiel and Ron Naaman. PR photo

This creates purer drugs with fewer side effects

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The general concept: the drug is injected into the blood system but is activated only in the selected place, using external illumination into the relevant tissue. Courtesy of the Technion spokesperson.

Light medicine: release of drugs in a precise place in the body without invasive intervention

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Comparison between computer models (in green) and experimental structures (in purple). Accuracy at the single atom level in both the overall structure (left) and the loop segments (right). Source: Weizmann Institute magazine.

A computerized method for the production of artificial proteins

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Cross section of the large subunit of the bacterial ribosome. In yellow - the exit tunnel of the proteins from the ribosome. In red - the binding pocket of erythromycin at the entrance to the tunnel. Bottom right (marked in light blue) – the ribosomal protein L22. In structural and chemical terms, the protein is distant from the binding pocket of the antibiotic. Source: Weizmann Institute magazine.

Researchers have discovered how a mutation in a ribosomal protein helps bacteria develop resistance to antibiotics

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Source: pixabay.

A unique algorithm allows shortening the discovery time of drugs from years to months

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Tiny silk capsules that resemble silkworm cocoons may be used to transport antibodies and drugs

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Source: pixabay.

Hidden side effects: Medical studies often omit negative results

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Dr. Zvi Chioka. Source: Courtesy of the Hebrew University.

Researchers have developed antibiotics against antibiotic-resistant bacteria

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The graphene layer (gray) leads the nanomedicine (white, red and blue) to the outer wall of the cell (yellow and red). Source: Courtesy of IBM.

Researchers at IBM have discovered a new way to stimulate an immune response in the body using nanomaterials

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Dr. Omri Koren, Bar Ilan Faculty of Medicine in the Galilee. Source: Bar Ilan University.

What is the effect of giving penicillin in early stages of life?

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Livestock animals, who are raised in high density, are given antibiotics that encourage resistance in bacteria, which eventually end up in our food. Source: pixabay.

The pathway of drug-resistant bacteria from the farm to the dinner table

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The plant Arabidopsis, after genetic engineering (right) during which 11 genes involved in the production of cholesterol were inserted into it, produces cholesterol in a quantity 15 times greater than a normal white Arabidopsis (left). Source: Weizmann Institute magazine.

green cholesterol

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antibiotic drugs. Illustration: pixabay.com.

"Antibiotics are like an atom bomb on the microbiome"

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Photo from a malaria vaccination project in the Solomon Islands. Source: Jeremy Miller, AusAID, Department of Foreign Affairs and Trade, Flickr.

I know you from where?

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Compugen company employees on the eve of the offering

Immune Control Protein Discovered by Compugen Shows Potential for Developing New Cancer Immunotherapy Drugs

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