Weizmann Institute

T cells of the immune system attack a cancer cell. Illustration: shutterstock

Cancer cells' secret recipe for protein production may become a weapon against them

The findings of the research findings are presented graphically and tangibly on a website dedicated to the public, created by the scientists in collaboration with the designer Itay Reva. To the website To the website Illustration: Itai Ravehkar are presented graphically and tangibly on a dedicated site open to the public created by the scientists in collaboration with the designer Ai Raveh. Click on the image to go to the website. Illustration: Itai Rava

The globe of concrete

During 2020, human products exceeded the mass of all life in our world. ​The mass of buildings, cars and bottles doubles every 20 years - and the curve is about to flatten
A helical lock (orange) on the DnaJB1 chaperone blocks the binding site for chaperones from the Hsp70 family

Overcome the precipitation

The discovery of a mysterious helical lock may shed light on the development of degenerative brain diseases
An eye of a fruit fly engineered to develop an ALS-like disease. Left: Defective protein aggregates leading to ALS-like degeneration. Right: the eye returned to normal following the expression of one of the "sumo" proteins

Heavy weight pellets

Weizmann Institute of Science scientists deciphered the molecular mechanism of "return to normal" and discovered that it is based on labeling proteins for destruction with a special code known as "SUMO"
differences between the sexes. Illustration: depositphotos.com

Differences between the sexes - the worm version

Recently, Weizmann Institute of Science scientists compared neural networks of female and male worms, and discovered a molecular mechanism that may explain how differences between the sexes in neurological diseases in humans arise
Odors may be measured by their distance from each other. Prof. Noam Sobel's laboratory, Weizmann Institute

The smell index: a new method makes it possible to accurately measure similarity between smells

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The development by Weizmann Institute of Science scientists makes it possible to predict what the smell of any molecular compound will be and may pave the way for the digitization and reproduction of smells
Creative thinking. Illustration: shutterstock

The human mind presents: organized noise is the father of invention

A new study by Weizmann Institute of Science scientists offers an explanation for these magic moments, when new ideas sprout in us
Bacteriophage - a virus that attacks bacteria. Illustration: Illustration: depositphotos.com

A mysterious component in bacteria has been discovered as a last line of defense against viral infection

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Besides solving a 36-year-old mystery, Weizmann Institute of Science scientists have identified thousands of types of these components, which may be used in gene editing
cancer cell Image: Shutterstock

The memories of a cancer cell

A group of scientists at the Weizmann Institute of Science recently investigated what happens to cellular memory in cancer. Their findings illustrate how "memory loss" may affect the course of malignant diseases
Mouse liver tissue under the microscope. Signs of acute liver failure (left) disappeared after administration of a drug that blocks the control protein MYC

Involvement of intestinal bacteria and liver cells in acute liver failure

Weizmann Institute of Science scientists revealed the discovery and outlined a path for future treatment
The scarred surface near the North Pole of the Moon as captured by one of the cameras of NASA's LRO probe. The first step of the researchers was to decipher the two-dimensional images in an attempt to understand how many pits and depressions there are in these areas, what their possible depth is and what proportion of their surface is permanently shaded NASA /GSFC/ASU

The frozen side of the moon

A new study by Weizmann Institute of Science scientists and their research partners in the USA indicates that at least some of the water on the moon may be trapped in much more accessible places - in pits and small depressions.
protein folding. Photo: Mohammed AlQuraishi, Harvard University.

Self contained but not sealed to the environment

Are proteins more "exposed" precisely when they are folded?
Falcons in the window. Photo: Weizmann Institute Spokesperson

Falcons in the window

In the spring of 2019, the pot in the window of Shlomit ben Meshulam in the Department of Veterinary Resources became a falcon's nest. Shlomit, the secretary of the department, accompanied the chicks until they flew from the nest
Cardiac tissue regeneration under the microscope. In the picture you can see thin green stripes that mark the cleavage furrows that form between the heart muscle cells (in red) that are dividing. The laboratory of Prof. Eldad Tzhor, Weizmann Institute

Heal the heart with the help of cancerous processes

Researchers from the laboratory of Prof. Eldad Tzhor from the Weizmann Institute discovered that given the right signal, mature cardiac muscle cells in mice can revert to an earlier developmental state and replace the scar tissue with tissue
Three archaeological items, three different degrees of heat (right, not to scale): blade, chipped spatter, and spontaneously spattered flint shards

Controlled use of fire to create tools - already about 300 thousand years ago

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Researchers at the Weizmann Institute of Science and Tel Aviv University have recently applied their own sophisticated technologies to examine how stone tools were produced at the end of the Paleolithic period found in Kesem Cave near Rosh Ha'Ein
Ice crystals in an environmental scanning electron microscope (ESEM), courtesy of Dr. Anna-Eden Kosoy-Simkov, Department of Chemical Research Infrastructures

go with the flow

In a series of experiments, Weizmann Institute of Science scientists solved the puzzle of the relationship between electric current and the freezing temperature of supercooled water. Beyond the scientific interest, their findings may lead to the promotion of applications in diverse fields
When the scientists inhibited the production of the nucleic acid purine in the cancerous tissue (right), more T cells of the immune system penetrated it during the immunotherapy phase, compared to tissue that had not been pretreated with purine inhibitors (left). Photo production: Dr. Raya Elam

Vulnerability is acquired

Weizmann Institute of Science scientists, in collaboration with researchers from the National Cancer Institute and Ben-Gurion University of the Negev, recently found a genetic signature that differentiates between tumors that may respond to immunotherapy and tumors that are resistant to this treatment method. apart from a tool
A cell of Nicotiana benthamiana under a microscope. On the left: the intraplasmic reticulum (marked in green), in the center: the enzyme SOAP5 (marked in red) and on the right - a combined image revealing that SOAP5 is surprisingly found inside the intraplasmic reticulum

Foam over the spinach

In a new study, Weizmann Institute of Science scientists revealed the chain of biochemical reactions responsible for the production of saponins in plants, and discovered that it includes a surprising case of molecular "hijacking". The scientists even recorded an achievement in the field of synthetic biology:
Brain activity in the hypothalamus in response to body odors. The level of activity in women who had repeated miscarriages (pink dots) was higher than in women in the control group (green dots). The laboratory of Prof. Noam Sobel, Weizmann Institute

Relationship between unexplained miscarriages and women's brain response to men's body odor

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In a new study published today in the scientific journal eLife, the researchers from Prof. Noam Sobel's laboratory at the Weizmann Institute showed that women who suffer from repeated and unexplained miscarriages perceive men's body odors differently than women
Illustration: Courtesy of the Weizmann Institute

the heart key

As the word spread and panic gripped the public, the city officials ordered the killing of London's cats and dogs on the assumption that the fleas they carry were spreading the deadly bacteria. The assumption was not wrong - fleas do indeed carry the disease-causing bacteria - but the trustees of public health forgot an important factor in the equation: the rats. Photo: H. Zell, Wikimedia.

Mustache signature

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A bacteriophage (upper right) penetrates a bacterial cell (center of the picture). Bacteria have highly sophisticated immune systems specially prepared to fight viruses

Antivirals discovered in bacteria may be used as drugs for viral diseases

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These days, the ability of these substances to fight viruses that harm humans, including the flu and corona viruses, is being tested
The virtual signature stand. The President of the Weizmann Institute, Prof. Alon Chen, and the Minister of Industry and Advanced Technology of the United Arab Emirates, Dr. Sultan Ahmed Al-Jaber

The Weizmann Institute and Mohammed Bin Zayed University in the United Arab Emirates signed a collaboration in the field of artificial intelligence

The academic cooperation is made possible thanks to the normalization agreement between Israel and the United Arab Emirates that will be signed this week in Washington, USA, and the relationship between the two institutions was created with the assistance of the Intelligence and Special Operations Agency and its chairman
The silencing of the Piezo2 gene in the neurons of the proprioception system led to deformities in the hip joint in the transgenic mice (right) compared to a normal hip joint (left). Photographed using a micro-CT system

The movement to repair the skeleton

It is possible that movement therapy can become part of the treatment protocol for scoliosis, hip dislocation and other skeletal deformities, the treatment of which is currently generally based on the restriction of movement
Cosmic scene with DNA, stars, solvents and atomic circles in oral flow.

walk between the drops

When the NXF1 protein is in the cells properly (left), the RNA molecules (orange dots) of a particular single-exon gene are exported from the nucleus (marked in purple) into the cell fluid. When NXF1 is silenced (right), RNA molecules are mostly stuck in the nucleus

Export in the slow route

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The "export" of RNA from the cell nucleus - a necessary process in the creation of proteins and the existence of life in a cell with a nucleus - was previously considered to be uniform and fast. In a new study, Weizmann Institute of Science scientists revealed that there are at least
fire Currently approved for the treatment of prostate cancer patients in early stages in Europe, Mexico and Israel

New light on "Toked"

Follow-up using a new imaging method, changes were discovered that lead to the eradication of the tumor in a selective manner and without damage to the adjacent tissues
Tracking the exact locations of the edge states allowed scientists to construct spatial maps of the local twist angles with unprecedented resolution and accuracy. These maps reveal a complex landscape pattern of valleys, peaks and saddle points

put the margin in the center

"The electrical properties of the material depend to a large extent on the exact twist angle. In other words, areas with different twist angles should be treated as different materials connected to each other, says Prof. Eli Zeldov
Illustration: Sharon Tesh, for the Weizmann Institute

On sleep, memory and the sense of smell

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Confocal microscopy image of peripheral nervous system sensory neurons in culture. Courtesy of the Weizmann Institute

A new approach to the development of chronic pain treatment

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Proof that drugs already approved for other purposes can be used to treat chronic pain sufferers. Since the safety of these compounds has been proven in humans, clinical trials for the new use are already possible in the near future.
Electron transition in solid matter. Courtesy of Prof. Nirit Dudovich, Weizmann Institute

New light on solid state: How fast flashes of light might change the properties of solid matter?

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A two-photon microscope image of a direction-coding cell in a mouse retina (the cell and its dendritic tree are marked in red) and around it starburst cells (in green) which are essential for calculating the direction of movement in most of the direction-coding cells

new direction

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Reprogrammed cells: beta cells that produce insulin (marked in green) and their "relatives" - delta cells that produce somatostatin (marked in red). Reprogrammed cells often contain two nuclei (marked in blue) - evidence that they are originally exocrine cells. Prof. Michael Walker's lab, Weizmann Institute

Turn his skin cell?

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On a natural barrier that interferes with the reprogramming of pancreatic cells
Confocal microscopy image of sensory neurons of the peripheral nervous system in culture (the cells and their extensions are marked in red). You can see in the neurons a combination of colors (blue-red-green) created as a result of marking the cell nuclei in blue and marking the transcription factor c-Fos in green. The scientists discovered that c-Fos is introduced into the nuclei by means of importin alpha-3 (the blue markings around - nuclei of other types of cells that are also in the culture)

A new approach to the development of chronic pain treatment

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Imaging of communication between two cells of the immune system - a "combatant" T cell and a "suppressor" myeloid cell. The yellow sparks are meant to illustrate intracellular processes that can be detected using the new method

New technology allows a "peek" into what is happening inside cells

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Strontium titanate at atomic resolution. split personality

Crystalline personality disorder

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The method is based on the superpolarization of the hydrogen nuclei in water molecules at a temperature close to absolute zero and then sprinkling them on biological molecules under physiological conditions

cold shower

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The evolution within the evolution. Illustration: Maya Shleifer

The evolution within the evolution

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Cross section of the zebrafish heart 30 days after injury. The injured site (marked by an arrow) without a scar in a fish with normal lymphatic vessels (left) but not in a mutant fish that does not have these vessels (right)

heart of a fish

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"Protein factory" on a chip. Courtesy of the Weizmann Institute

Weizmann Institute scientists created artificial cells on a chip and managed to assemble synthetic parts of a virus into them

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the lungs. From jumpstory

A new approach to personalized cancer medicine: listening to the internal messages inside the tumor cells

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Visualization of the Temple Mount during Herod's time. Marked with an arrow - Wilson's arch. Courtesy of the Weizmann Institute

on seeds and stones

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A mixed forest plot of carobs, oaks, pines and other trees near Beit Shemesh. The researchers are looking for symbiotic relationships between different species of fungi and trees

The disappearing mushroom

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Schematic representation of individual molecules in a crystal showing the development of order from lowest (red) to highest (blue)

Formation games - about the order emerging from disorder

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the electron dance. Prof. Shachel Ilani's lab, Weizmann Institute

the electron dance

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Is it possible to reconstruct the Earth's magnetic history using glacier samples?

The Earth's magnetic history is written in ice

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Micro-CT imaging of the crystal

Crystal in surprise

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Mouse T cells containing nanobubbles (red) that were secreted by the bilaterian

What does the worm want?

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The heart of the detector in the "Xenon 1 Ton" experiment. The world's most sensitive to dark matter

The scientists of the "Xenon 1 Ton" experiment identified a larger than expected amount of events that may indicate the existence of new physics

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La Rinconada in the Peruvian Andes. One of the hardest places to live in the world (Axel PITTET - Expedition 5300©)

panic for oxygen

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