In May 2020 preliminary results from CORONADO with a smaller sample showed that 10% of patients with diabetes and corona died within 7 days of hospital admission.
Updated results from the CORONADO study, which analyzes the outcomes of patients with diabetes who were hospitalized with Corona, show that one in five patients dies within 28 days while approximately half are discharged. The study is published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) and was written by Professor Bertrand Carreau and Professor Sami Hege, diabetes specialists at the Chest Institute, Nantes University Hospital, INSERM, CNRS, and the University of Nantes, France , and colleagues.
In May 2020 preliminary results from CORONADO with a smaller sample showed that 10% of patients with diabetes and corona died within 7 days of hospital admission.
This updated analysis included 2796 participants from 68 centers across France: almost two-thirds (64%) were men, average age 70 years, with an average body mass index of 28 kg/m44 (in the overweight range). Diabetic complications in small and large blood vessels were found in 39% and XNUMX% of the participants, respectively.
Within 28 days, 1405 (50%) of the patients were discharged from the hospital with a median length of hospital stay of 9 days, while 577 patients died (21%). Of the remaining patients, 12% remained in the hospital at day 28, while 17% were transferred to facilities other than their first hospital.
A computer model revealed various factors such as younger age, routine diabetes treatment with the drug metformin and longer duration of symptoms at admission were associated with a greater chance of discharge from the hospital.
A history of small vessel complications, routine anticoagulation (to prevent blood clots), shortness of breath on admission, abnormal levels of liver enzymes, higher white blood cell counts, and higher levels of the systemic inflammation marker C-reactive protein were all associated with a lower chance of discharge and greater risk of death. Patients whose diabetes was regularly treated with insulin (a possible indication of a more advanced state of diabetes) were 44% more likely to die than those who were not treated with insulin.
An unusual finding from this study was a 42% increase in the risk of death in patients with diabetes who were treated with statins for high cholesterol - but the authors make it clear that since this is an observational study, it is difficult to draw firm conclusions about any link to statins, or any other treatment.
The study also found that long-term control of the blood sugar level assessed by glycated hemoglobin (HbA1c) before admission or at admission did not affect the fate of corona patients, with no significant relationship to death or discharge within 28 days. In contrast, an increased level of plasma glucose on admission was a strong predictor of death and, accordingly, of a lower chance of discharge.
The authors conclude: "The identification of positive variables associated with discharge from the hospital and negative variables associated with death can lead to a reclassification of patients and help to use appropriate resources according to the profile of the specific patient."
More of the topic in Hayadan:
