Researchers from Ben Gurion University discovered that the compatibility between the proteins in the tissue and the quality control system begins to operate already in the life of the fetus during pregnancy and during development and is damaged in aging and age-dependent degenerative diseases
a
A new study of The National Institute of Biotechnology in the Negev, led by the female researchers Prof. Esti Yager-Lotam and Prof. Anat Ben-Zvi Recently published in a magazine Nature Communications
Many degenerative diseases, including Parkinson's, affect one tissue and sometimes only one cell type, but are caused by a defect in a protein that is expressed throughout the body. There are several possible answers to the question of how this happens.
A new study at Ben-Gurion University of the Negev tackled the question: Do quality control systems that repair damaged proteins (chaperones) affect this phenomenon? Quality control systems of proteins exist in all tissues of the body, but until now it was not known whether their action is uniform in all tissues or adapted specifically to the tissue.
The research, led by Prof. Esti Yager-Lotam from the National Institute of Biotechnology in the Negev and the Department of Clinical Biochemistry and Pharmacology and Prof. Anat Ben-Zvi from the Department of Life Sciences, examined 30 central tissues in the human body during development and adulthood and revealed with the help of computational tools and the use of extensive sources of information from humans that the system exists And necessary in all cells but adapted to the needs of each tissue - both in the amount of proteins and in the interaction between them. The compatibility between the proteins in the tissue and the quality control system begins to operate already in the life of the fetus during pregnancy and during development and is damaged in aging and age-related degenerative diseases.
The study revealed a new organization of the quality control system in humans and this organization affects the outbreak of diseases caused by mutations or aging. During aging, the protein loses its correct structure and accumulates in protein clumps (aggregates), but the specific quality control system of the brain changes with age and loses its ability to maintain the correct structure of the proteins.
Prof. Esti Yager-Lotem: "The discovery that certain proteins play a central role in a certain tissue and in a certain disease can make them a target for drug treatment that will preserve their ability to perform quality control even in old age and influence the rate of development of degenerative diseases. The research provided an infrastructure that may, in the long run, assist in the development of new drugs to treat degenerative diseases that are currently difficult to deal with."
More of the topic in Hayadan:
One response
I suffer from a very high c.pk in the values of 3000-4000. I did all the tests and photographs possible and there is no ointment. They just say that the protein is high and there is nothing to do. Moreover, in 10 years I will not be able to walk on my feet and it is only getting worse. I am being treated at a pain clinic in Tahash with Prof. Vera Nikitin I would be happy if there is a specialist doctor that I can go to