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Caspases

The cells labeled with fluorescent dyes in the primary tissues of the wing (left), eye (center) or leg (right) in the fruit fly larva, do not migrate when they have normal caspase activity (top row). When the caspases are removed, these cells begin to migrate after irradiation to other parts of the tissue (bottom row)

What happens when the mechanism for programmed cell death is removed from the cell

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Confocal microscope observation of two mature fruit fly testes filled with dividing germ cells (in green). About a quarter of these cells (in red and pink) die in the alternative death pathway

Alternative death

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Prof. David and Lech. Photo: Weizmann Institute

A warning call

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In the photo: 80-fold magnification of a developing wing in a fruit fly larva showing different aspects of apoptosis activated as a result of radioactive radiation - in a normal fly (left) and a mutant fly lacking Drice (right). In the top row: the expression area of ​​the "reporter" protein colored with green fluorescent color. In the middle row: fluorescent marking of the cutting of the "reporter" protein by the caspases after activation of apoptosis. Bottom row: fluorescent labeling of dead cells. In the normal fly many cells die after exposure to radioactive radiation, but in the fly without Drice there is almost no apoptosis

the exterminator

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The cellular "steam valve" discovered by Prof. David Valech. Illustration: Weizmann Institute

The scientists of the institute discovered a group of genes that suppress increased cell division

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