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Eran Perelson

Figure: A novel molecular mechanism of a messenger of death that travels from the end of the axon to the cell body and kills the spinal motor neurons after exposure to stress in ALS disease. This finding constitutes a new target for drug development and future treatment.

Why do nerve cells die?

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For the first time: a mechanism has been revealed that damages the nerve cells in the terminal muscular dystrophy (ALS) * CRMP4 serves as a "messenger of death" that moves along the nerve extension and kills motor neurons in the ALS disease * Rescued motor neurons in mouse models and human models of the disease
Stephen Hawking at the Science Museum in Jerusalem, December 2006. Photo: Avi Blizovsky

A new discovery paves the way for the development of a treatment for the degenerative disease ALS

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Neurons in XNUMXD. Illustration: shutterstock

Researchers at Tel Aviv University have identified the mechanism that causes the death of neurons in familial dysautonomia - and are offering a first-of-its-kind treatment

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