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Eran Hornstein

Microglial cells that were "ripened" in the laboratory from stem cells derived from ALS patients (in green), the cell nuclei - in blue. Photographed using a confocal microscope

The good mutation

Weizmann Institute of Science scientists have discovered a new pathway that may protect nerve cells in the brain and slow down the development of degenerative brain disease
An eye of a fruit fly engineered to develop an ALS-like disease. Left: Defective protein aggregates leading to ALS-like degeneration. Right: the eye returned to normal following the expression of one of the "sumo" proteins

Heavy weight pellets

Weizmann Institute of Science scientists deciphered the molecular mechanism of "return to normal" and discovered that it is based on labeling proteins for destruction with a special code known as "SUMO"
MRI scan of an ALS patient. Source: Frank Gaillard, Wikimedia.

Searching for the genetic roots of ALS in new territories

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Survival - in the brain

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Medicines. Illustration: shutterstock

Small molecules, big hopes

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Micro RNA. Illustration: Prof. Robert Johnson, Temple University

Between precision and efficiency: how do the cutting machines of the cell maneuver?

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From the right (standing): Roni Oren, Dr. Tali Melkman-Zahavi, Sharon Cardo-Russo. (Sitting): Amitai Mandelbaum, Natalie Rivkin and Dr. Eran Hornstein. a positive factor

micro-macro

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Coloring of the meeting areas between nerve cells (green) and muscle (red). The yellow staining represents complete overlap between the nerve cells and the muscle in normal mice (bottom). In transgenic mice, which lack microRNA in nerve cells that innervate muscles, only the muscle staining is visible (above, in red), because the nerve in the junction area is diseased. Illustration: Weizmann Institute

ALS - suddenly in the middle of life

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The motor neurons, which control voluntary muscle movement, gradually degenerate. As a result, the patient loses the function of most muscles
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