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Changes in DNA organization during sperm cell development. From left to right: developing sperm cells (beginning of meiosis), developing sperm cells (after meiosis) and mature sperm cells. Top row: microscope images of the cells with the DNA marked in black. Bottom row: Hi-C experiment interaction maps, depicting spatial structures of DNA (rectangular shapes). You can see that at the beginning of meiosis, when the DNA is compacted, the structures are present but weaker; They get stronger after meiosis; And they reach their peak strength in mature sperm cells. Illustration by Prof. Stoshi Namakawa, Cincinnati Children's Hospital

New discoveries about DNA organization during sperm formation

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