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receptors

4D structure of the stemalnotide drug molecule (pink) and calcium ion (green) in the binding pocket of the MCXNUMX receptor

The Hunger Games: the mechanism of action of the switch in the brain responsible for the feeling of satiety

Understanding the mechanism is expected to help in the development of new anti-obesity drugs
When the level of PYK2 is lowered through genetic engineering, metastatic breast cancer cells (left) revert to a non-invasive state (right). In this state they come into contact with each other and take the form of healthy tissue cells. Source: Weizmann Institute.

On the occasion of International Women's Day 2016: three goals

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synapses in the brain. Illustration: shutterstock

A receptor in the brain - a possible key to prolonging life and developing a cure for Alzheimer's

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In the framework of the 'rotational model', a ligand that binds to the extracellular part of the receptor causes the internal part of the receptor to rotate within the cell membrane, thus essentially regulating the activity inside the cell. In the process, the structural flexibility of the receptors also changes. [Courtesy of Okinawa Institute of Science and Technology, OIST]

A new mechanism for receptor activation

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A person itches. Image - Orrling and Tomer S. CC license from Wikipedia

The molecular mechanism that causes itching was discovered

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Prof. Robert Lebkovitch, winner of the 2012 Nobel Prize in Chemistry

An injection of adrenaline for science: two researchers in the field of intercellular communication won the 2012 Nobel Prize in Chemistry

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