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Yaakov Hana

A mouse fetus grown six days outside the womb. His developing organs were marked with fluorescent genes

Weizmann Institute scientists grew mouse embryos outside the womb

For seven years, through trial and error, fine-tuning and repeated tests, in the laboratory of Prof. Hana, who specializes in embryonic stem cells, they developed a two-stage method that makes it possible to grow normal mouse embryos outside the womb from the initial stages of pregnancy in order to study the different stages of development of the embryo, Something that was not possible in mammals until now
From the right: Dr. Noam Stern-Ginosar, Aharon Nachshon, Julie Tai-Schmidel and Roni Winkler. Uninvited guests. Photo: Weizmann Institute spokeswoman

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Mouse embryonic stem cells were observed using a spinning disk confocal microscope. The levels of the protein that prevents stem cells from differentiating (green) decrease in the presence of high levels of another protein (purple) that causes mitochondria to elongate

The elongation of mitochondria in embryonic stem cells affects the process of differentiation into the various body tissues

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Prof. Dan Farr, Tel Aviv University

7 scientists joined the Israeli Young Academy * Israel officially joined the Horizon 2020 program

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From the right: Assaf Tzviran, Dr. Yaacov Hana, Yoach Reiss, Dr. Noa Noverstern and Shai Gaola. a decisive step

A method for increasing the production efficiency of the stem cells

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Completely neutral human induced stem cells, produced by Dr. Hanna's method (in green and yellow), integrate into different tissues of a mouse embryo (in red) Video: A video showing the integration of neutral human induced stem cells, produced by Dr. Hanna's method (in green and yellow) in the tissues of a mouse embryo (in red). Photo: Dr. Yaakov Hana, Weizmann Institute

For the first time: completely "neutral" human stem cells, which developed into tissues inside a mouse embryo

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Dr. Yaakov Hana. Photo: Weizmann Institute

A new method for increasing the production efficiency of stem cells

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Doctor Shagiv Shipman (right) and Eyal Ben-David. Photo: The Hebrew University

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Embryonic stem cells that develop into gametes, from which the gene encoding the Utx enzyme has been deleted, are labeled with a bright green fluorescent protein. In each of the columns is marked (in red, purple or orange) a gene essential for the survival and development of the gametes. A comparison of the tenth day of cell development (top row) with day 12 (bottom row) shows that the expression of the four essential genes is stopped. As a result, the stem cells do not develop into sperm or egg cells, but die. Photo: Weizmann Institute

back to the Future

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