Comprehensive coverage

The brain - serious diseases

Neurological disorders and memory loss. Illustration: depositphotos.com

An existing drug will be substituted for the treatment of an orphan disease

A large-scale international study led by Tel Aviv University found that an experimental drug that received orphan drug status from the FDA for the future treatment of a rare developmental syndrome, may also cure a variety of symptoms related to autism, intellectual disability and Alzheimer's
neurological diseases. Illustration shutterstock

A main mechanism in the development of muscular dystrophy is deciphered

  • No comments
Mutations causing S1R dysfunction are one of the causes of ALS (muscular dystrophy) and hereditary motor neuropathy. In another context, this receptor is a target site for the drug cocaine
The puzzle - the symbol of autism. Illustration: depositphotos.com

A surprising link between autism and Alzheimer's

A new study led by Dr. Haitam Amal reveals a common molecular mechanism for autism and Alzheimer's, which will help in understanding the pathological mechanism in both disorders
Nerve cells of a healthy person (above) compared to a similar cell of a Parkinson's patient. The lack of dopamine causes neurological disorders. Illustration: depositphotos.com

Pioneering Israeli development will facilitate surgeries for Parkinson's patients

Researchers at the Hebrew University and the Hadassah Medical Center have developed a method of anesthesia that will allow Parkinson's patients to undergo surgery that significantly alleviates the disease even in a state of confusion. Prof. Hagai Bergman: "This is a significant development for patients who, until today, most had to undergo brain surgery in an alert state"
Hippocampal dentate gyrus in HSHA mice, showing significant activation of astrocytes (GFAP: white) and oxidative stress (8OHdG: green) surrounding brain capillaries (laminin-a4: reddish). Nuclei are stained with DAPI (blue). Credit: John Charles Lewis Mammo, Lam V et al., 2021, PLOS Biology. Credit: John Charles Louis Mamo, Lam V et al., 2021, PLOS Biology

Protein from the liver may cause Alzheimer's disease in the brain

  • No comments
Summary: Amyloid-beta proteins formed in the liver are carried in the bloodstream by lipoproteins to the brain. This causes neurodegradation, brain degeneration and inflammation, common features of Alzheimer's disease.
both halves of the brain. Illustration: depositphotos.com

The sac that connects the two parts of the brain has a role in communication between them in different behavioral situations

  • 3 תגובות
Surgeries to sever a lobe of the brain were the solution to epilepsy, but it turned out that we did more harm than good. Now researchers at the Weizmann Institute of Science explain the mechanism that links the two parts of the brain, and why damage to it endangers the patient
wakefulness and sleep cycle. Illustration: depositphotos.com

You should sleep before an exam: lack of sleep sabotages the storage of new memories in the hippocampus

  • No comments
Mice that suffered from a lack of sleep increased the activity of inhibitory neurons in the hippocampus, thereby disrupting the processing and storage of new memories.
Three-week-old organoids from a patient with WOREE syndrome. The organoids are expected to grow significantly and reach up to about 4 mm in diameter. The laboratory of Prof. Akilan, Hebrew University.

"Mini Brain" helps to treat a rare and incurable brain disease in childhood

The research is based on technological breakthroughs of the last decade, which enable the study of human diseases in a personalized model for the patient
Figure: A novel molecular mechanism of a messenger of death that travels from the end of the axon to the cell body and kills the spinal motor neurons after exposure to stress in ALS disease. This finding constitutes a new target for drug development and future treatment.

Why do nerve cells die?

  • No comments
For the first time: a mechanism has been revealed that damages the nerve cells in the terminal muscular dystrophy (ALS) * CRMP4 serves as a "messenger of death" that moves along the nerve extension and kills motor neurons in the ALS disease * Rescued motor neurons in mouse models and human models of the disease
diseases of old age. Photo: depositphotos.com

The organization of the quality control system of proteins affects the onset of neurodegenerative diseases

  • One response
Brain deletion in Parkinson's patients. Photo: depositphotos.com

A new direction for drugs that will slow down the development of Parkinson's

Researchers from the Hebrew University and Penn State University revealed for the first time the structures of the central protein in the early stages of Parkinson's disease. Dr. Eitan Lerner: "The findings may help in the development of drugs that will help slow the pace of the disease and possibly even prevent it"
Prof. David Sheprincek and research student Udi Binstock from the School of Neurobiology, Biochemistry and Biophysics at Tel Aviv University. PR photo

A new study on the brain of zebrafish has proven that new neurons are formed in the brain in an orderly and coordinated manner

  • 2 תגובות
The researchers found that the activation process of stem cells in the brain responsible for the production of neurons (nerve cells) is not random but ordered and coordinated. According to them, the findings are of great importance for understanding the normal development of the brain. The findings may form the basis for the development of future treatments for brain cancer, for degenerative diseases of the brain such as Alzheimer's and Parkinson's, and for various brain injuries
Dr. Deborah Tober. Photo: Danny Machlis, Ben-Gurion University of the Negev.

Scientists have been able to identify the genes that influence a healthier aging process

  • 3 תגובות
Researchers from Ben-Gurion University of the Negev are leading innovative research on understanding the molecular processes in the aging process and have found genes that can predict healthy aging and help prevent diseases
A model for the slowing down of the digestive system following the expression of alpha-synuclein protein in the brainstem. Credit - courtesy of the researchers

Constipation and contraction of brain cells - the key to an early diagnosis of Parkinson's disease?

In a study led by Prof. Yehoshua Goldberg from the Hebrew University, it was found that the contraction of brain cells may explain the constipation symptom among Parkinson's patients. The important finding is expected to help in the future in the diagnosis of Parkinson's disease already in its early stages
Brain wave recording. Photo: depositphotos.com

Researchers at Ben-Gurion University present a new method for diagnosing neurological and psychiatric diseases

  • One response
The method, which is based on EEG patterns in abnormal electrical brain activity, can quickly diagnose and monitor pathologies in the blood vessels in the brain that are observed in conditions such as Alzheimer's disease, stroke, head injuries and psychiatric conditions
the brain. Photo: depositphotos.com

The google maps of the brain: locating RNA fragments in brain cells without removing the tissue

  • One response
Dr. Shahar Alon, who came from MIT to the Faculty of Engineering at Bar-Ilan University, was a partner in the study together with researchers from Harvard and MIT * "Using our technology, researchers and doctors will be able to perform genomic analysis in XNUMXD - to obtain not only the identity of the molecules, but also the Their location within the tissue and thus better and more efficient treatment of complex diseases"
Stroke. Photo: depositphotos.com

This is how the body sets up a unique emergency team against stroke using RNA-guide fragments

Guide RNA fragments, which until recently were known as the breakdown stages of the guide RNA on the way to their elimination from the body, were discovered in a new study led by Prof. Hermona Sorek from the Hebrew University, as molecules of great importance in preventing the collapse of the immune system following a stroke, the risk of which increases in corona patients
Dr. Haitam Amal, Head of the Laboratory for Neuro-Omics, Signal Transduction, and Translational Medicine at the Faculty of Medicine at the Hebrew University. Public Photo

Advances in understanding brain aging

Dr. Haytam Amal from the Faculty of Medicine developed an innovative method that will lead to the development of targeted treatments for various neurological disorders
differences between the sexes. Illustration: depositphotos.com

Differences between the sexes - the worm version

Recently, Weizmann Institute of Science scientists compared neural networks of female and male worms, and discovered a molecular mechanism that may explain how differences between the sexes in neurological diseases in humans arise
neurological diseases. Illustration: shutterstock

A new mechanism for the development of Alzheimer's and Parkinson's

  • 6 תגובות
Dr. Oren Shariki, from the Department of Cognitive and Brain Sciences at Ben-Gurion University. Photographer: Danny Machlis

Researchers at Ben-Gurion University have developed a system for predicting epileptic seizures

  • 2 תגובות
NeuroHelp, the recently established start-up company that received a license for the development and commercialization of the technology, is a portfolio company of the Oasis Accelerator, of the 360 ​​Entrepreneurship Center of Ben-Gurion University
Psychotic disorders. Illustration: shutterstock

A blood test can predict who is likely to develop psychotic disorders

  • No comments
The researchers analyzed blood samples taken from people who are at high clinical risk for psychosis. These people were followed for several years to see who developed a psychotic disorder and who did not.
Dr. Alal Eran. Photo: Danny Machlis, Ben Gurion University

Researchers have linked for the first time between high cholesterol in the mother and the risk of autism

  • 4 תגובות
Prof. Ilana Gozes. Photo: Tel Aviv University

An experimental Alzheimer's drug may help children with autism

  • One response
Yuval El-Hannani, Prof. Yizhar Bar-Gad, Ila Matzner. Bar-Ilan University photo

Brain researchers from Bar Ilan won an international award sponsored by the Michael J. Fox Foundation for Parkinson's Research

  • 2 תגובות
Science website logo
SEARCH