microglia

Prof. Ronit Saatchi Fainero. Photo: Tel Aviv University spokesperson

Attacking brain tumors

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Prof. Ronit Sacchi-Painero identified two key proteins – CCL2 and P-Selectin – that are involved in cancer cell entry into the brain. Blocking either axis significantly reduced metastatic burden in mouse models and in vitro systems.
Microglial cells (in green) in the hippocampus region of the brain of an adult mouse, forming contact points with a new neuron (in red)

The biology of depression

Degeneration of the cells of the immune system in the brain may be the biological cause of depression, and there may be substances that can restore these cells - and be antidepressants
Mouse brain tissue. The octopus-like microglial cells are marked in red. In green - blood vessels. Courtesy of the Weizmann Institute

calm the microglia in the brain

In degenerative brain diseases, Alzheimer's for example, there is an overactivity of the representatives of the immune system in the brain. Weizmann Institute of Science scientists have revealed the mechanism that allows these cells to return to normal
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