metastases

Prostate cancer. Illustration: depositphotos.com

Making drug resistance a weak point in metastatic prostate cancer

A new computational tool, SpotNeoMet, developed at the Weizmann Institute, detects resistance mutations that recur in many patients and create neoantigens – a possible target for “precision” immunotherapy for broad patient groups
The D'20 peptide inhibits the cancer-causing enzyme MMP7. The image was prepared using DALEE and is not a scientific image

A new stable and selective inhibitor of a cancer-causing enzyme has been revealed in a new study

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Researchers from the Hebrew University, the Weizmann Institute and the University of Tokyo have developed an innovative peptide that suppresses the activity of the MMP7 enzyme associated with cancer progression, with the potential for targeted therapies in aggressive cancers.
Cross-sectional image from a confocal microscope: breast cancer cells with high metastatic potential push into a polyacrylamide gel with a stiffness of 2.4 kPa, where this section is at a depth of 10.6 microns below the surface of the gel. In the picture you can see the cell nuclei (red), the actin element in the intracellular skeleton (green) and the connections of the cells to the surface at connection centers (blue).

A fatal warning: researchers have developed a method for estimating the metastatic potential of cancerous tumors

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Thyroid cancer cells. Source: NASA / Team Daniela Grimm.

Carcinogenic groups

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When the level of PYK2 is lowered through genetic engineering, metastatic breast cancer cells (left) revert to a non-invasive state (right). In this state they come into contact with each other and take the form of healthy tissue cells. Source: Weizmann Institute.

On the occasion of International Women's Day 2016: three goals

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From the right: Benny Shapiro, Dr. Nancy Gebert and Prof. Avri Ben-Zev. Standing behind: Anna Shoab and Gal Haz. "The Good Hero". Photo: Weizmann Institute

The double life of the cancer gene

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