immunotherapy

T cells attack a cancer cell. Illustration: depositphotos.com

The weapon against cancer: T cells based on chip manufacturing technology

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The rise of the clones. Illustrator: Itay Chen (student at the Rappaport Faculty of Medicine and professional illustrator of scientific illustrations).

Technion discovery: Genetic "fingerprint" may improve the personalization of immunotherapy treatments

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Researchers at the Rappaport Faculty of Medicine have identified a genetic "fingerprint" that helps predict the effectiveness of these treatments.

A new direction for fighting cancer: making it incriminate itself

Prof. Yardena Samuels' lab at the Weizmann Institute of Science has succeeded in making cancer cells surrender themselves to the immune system. The new approach may offer hope to incurable patients
Schematic description of one of the approaches in the NanoBiCAR project: Nanoparticles, (1) carrying mRNA molecules that encode a genetically modified protein that activates the immune system, are introduced into the system and taken up by white blood cells formed in the bone marrow (2). These cells produce the protein from the mRNA molecules and secrete it (3). The secreted protein has a dual binding ability: on the one hand, it binds the cells infected with the tuberculosis bacterium (4) or the bacterium itself (5), and on the other hand, it binds killer white blood cells from the immune system (6). The dual binding activates inflammatory and immune processes (6) and ultimately leads to the killing of the cells infected with the bacterium or the elimination of the bacterium itself (7).

mRNA – from vaccines to the fight against tuberculosis

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Researchers from the Technion's Faculty of Biology will develop a new approach to combat infectious diseases as part of the European consortium NanoBiCar. This is the first attempt to use mRNA molecules for tuberculosis and other bacterial diseases in light of the difficult problem of bacterial resistance.
A sample from a tumor of a human patient with the most common lung cancer (adenocarcinoma). The presence of senescent cells expressing the proteins P16 (in red) and PD-L1 (in green) can be detected. The cell nuclei in the sample are marked in blue

to open blockages in the immune system

immunotherapy. Illustration: depositphotos.com

Faster, stronger

Weizmann Institute scientists have developed a new approach to increase the rate of division of immune cells in the laboratory, while preserving their ability to kill cancer cells, and have identified optimal time windows in which the cells are particularly lethal. The method may promote
Photomicrograph of a biopsy from a patient's lungs. Illustration: depositphotos.com

Towards a new generation of treatments for old age diseases

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Advances in cancer immunotherapy. The image was produced by DALLE 3 artificial intelligence software and is intended for impressions. It should not be seen as a scientific picture

Technion researchers present a significant improvement in predicting the success of immunotherapy treatments

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The technology developed by Prof. Yuval Shaked's research group was registered as a patent and is now in the process of being commercialized
Battle team: A dendritic cell (right) and a T cell connected by BiCE antibody (in yellow). were produced from a lymph node of a mouse with skin cancer

Together we will win: combining forces between the cells of the immune system may lead to improved cancer treatments

Weizmann Institute of Science scientists have developed a new approach to immunotherapy based on communication between the cells of the immune system
Tissues removed from mice implanted with lung cancer cells engineered to produce high amounts of PSME4 (left column) or unmodified cancer cells (right column). When the protein is expressed in a high amount, the tumor is larger (top row, the tumor cells are marked in intense and concentrated purple), the number of T cells that can fight the tumor is lower (middle row, in white), and there are more cells that suppress the immune response (bottom row, in green)

The cancer to the basket and eliminated

The cell's garbage disposal system changes in cancer and allows it to escape the immune system
Prof. Yitzhak Weitz. Photo: Tel Aviv University

Prof. Yitzhak Weitz won the Saint-Georges Prize for the promotion of cancer research for 2023

His important contribution included a host of breakthrough insights and discoveries, publications and collaborations in the field of cancer research
immunotherapy. Image: depositphotos.com

Trying to treat cancer - and contributing to its aggressiveness

Immunotherapy treatment may cause the spread of cancerous tumors
A small vesicle that knows how to inhibit the binding of PD-1/PD-L1 and remind the immune system that it needs to attack the cancer. Screenshot from the video. Dr. Rita Acúrcio

A small molecule that will make the immunological treatment of cancer accessible to all patients

Prof. Ronit Sachi-Painero: "I believe that in the future the small molecule will be available and will make immunological treatment accessible and effective for cancer patients."
Cancer treatment. Illustration: depositphotos.com

Break the boundaries of immunotherapy

The method that may make the new generation of cancer treatments accessible to more patients
Proliferation of cancer cells in mice without eosinophils Credit: Tel Aviv University

The white blood cells may help to damage and destroy cancerous tumors

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The researchers found that the negative destructive properties of eosinophil-type white blood cells can also be used to damage and destroy cancerous tumors * The researchers discovered that eosinophils fight cancer cells in two ways
Solutions for the Corona epidemic. Illustration: Image by Miguel Á. Padriñán from Pixabay

Five seriously ill corona patients who received an experimental drug at Hadassah have recovered

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Enalivex reports positive results in a clinical trial of Allocetra for the treatment of corona patients in severe/critical condition
Imaging of communication between two cells of the immune system - a "combatant" T cell and a "suppressor" myeloid cell. The yellow sparks are meant to illustrate intracellular processes that can be detected using the new method

New technology allows a "peek" into what is happening inside cells

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fight against corona virus Illustration: Image by Fernando Zhiminaicela from Pixabay

Identifying a trap and finding the ultimate anti-coronavirus

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Blood test to detect the risk of lung cancer. Hekra and Ira - Dr. Tamar Paz-Elitzur

The smoking gun of DNA

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Cancer cell genome. Illustration: shutterstock

Biomarkers that may predict the chances of success of cancer immunotherapy

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The team of researchers. From right to left: Peleg Ryder, Diana Resoloniriana and Dr. Yaron Karmi Photo: Courtesy of Tel Aviv University.

Researchers have succeeded in developing an immunotherapy treatment platform that may be suitable for many types of cancer

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Skin cancer (melanoma). From Wikipedia

The chances of success of immunotherapy depend on the degree of heterogeneity of the cancer tumor

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Illustration: The Trojan horse represents the virus, which enters the cell and causes the creation of proteins. Their purpose is to call the immune system, so that it attacks the cancer cell only, without harming healthy cells. Source: Courtesy of the Hebrew University.

Researchers have developed a "switch" that activates the immune system to attack cancer cells when it detects signs of the disease

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On the left: a cancerous tumor under a microscope: the infiltration of normal T cells (purple) into the tumor tissue is not different from that of T cells that were grown under conditions of oxygen deficiency (green). Right: The amount of the enzyme "granzyme B" (red), which kills cancer cells, is much greater in T cells grown in a low-oxygen environment (top) compared to normal T cells (bottom). Source: Weizmann Institute magazine.

Combat fitness for cells

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Compugen company employees on the eve of the offering

Immune Control Protein Discovered by Compugen Shows Potential for Developing New Cancer Immunotherapy Drugs

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Awarding of the Kay Award to Dr. Pinchas Zuckerman from the Hebrew University. Public relations photo

The Kay Prize was awarded to Pinchas Zuckerman for the development of antibodies that destroy cancerous tumors

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