epigenetics

An illustration of epigenome editing: A CRISPR-guided system binds to a specific region of DNA and changes chemical marks that affect gene activity, without cutting the genetic sequence itself.

The Next Generation of CRISPR: Epigenome Editing Moves to Human Trials

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New systems use CRISPR's navigational capabilities to silence or activate genes without cutting DNA. First clinical trials in FSHD and hepatitis B are testing whether epigenetic modification can be targeted, safe
In recent decades, there has been a growing understanding that small parts of a city – specific street segments – may have a greater impact on crime. Illustration: depositphotos.com

Crime Hotspots: Does the Street We Live On Change Hormones Related to Aggression and Anxiety?

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A planned Israeli study will map street sections in Tel Aviv and examine whether living in areas with high crime is linked to testosterone and cortisol levels and measures of mental well-being.
Mitochondria in the cell: not only energy production, but also signals that direct gene expression

When mitochondrial DNA “directs” the immune system

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Liver infected with hepatitis. Illustration: depositphotos.com

When the virus leaves a mark: Epigenetic “stamp” after hepatitis C cure may explain ongoing risk of liver cancer

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Research led by Prof. Meital Gal-Tanaami of Bar-Ilan University and supported by the Israel Science Foundation is examining how a virus that remains in the cytoplasm manages to change genetic control in the nucleus, and is attempting to map points of intervention to reduce cancer risk as well.
CRISPR. Illustration: depositphotos.com

CRISPR Breakthrough: Epigenetic Editing Without Cutting DNA Could Transform Treatment of Genetic Diseases

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Australian researchers have developed a third-generation CRISPR method that allows genes to be turned on and off without damaging DNA, offering a safer way to treat diseases such as sickle cell anemia.
Prof. Oded Rechavi. Photo: Tel Aviv University

Tel Aviv 360 Podcast: Epigenetics – What Really Passes From Generation to Generation?

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With the participation of Professor Oded Rechavi, Department of Neurobiology, Faculty of Life Sciences and School of Neuroscience, Tel Aviv University (Hebrew only)
DNA methylation. Illustration: depositphotos.com

DNA Methylation Atlas: The Secret Map of Inheritance

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A study led by researchers from the Hebrew University reveals over 325,000 regions in the genome with methylation differences between the paternal and maternal copies – new insights into epigenetics and parental imprinting
The venom sac (Photo: Elad Hayal Laboratory, University of Haifa – Oranim Campus)

A bacterium is passed from generation to generation through wasp venom.

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Research reveals a unique way in which a bacterium hitches a ride on the venom of a parasitic wasp to pass from generation to generation, offering a new direction for studying the interactions between insects and microorganisms
epigenetics. Illustration: depositphotos.com

Breakthrough in epigenetics research: DNA methylation mapping reveals hidden genetic switches

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New Hebrew University research maps for the first time the differences in maternal and paternal DNA coding in the body's cells, providing new insights into genetic control, parental inheritance, and the impact of genetic diseases
Illustration: depositphotos.com

"The Early Warning Signs of Cancer: Epigenetic Discoveries That Inspire Hope"

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New study reveals that cancer risk may be determined before birth, suggesting new directions for diagnosis and treatment
Gene therapy. Illustration: depositphotos.com

Can we control genetic inheritance? New RNA research suggests it may be possible

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Researchers at the University of Maryland have discovered new pathways for double-stranded dsRNA to enter cells, revealing how RNA influences gene regulation over many generations – insights that could improve RNA-based drugs
Illustrative epigenetics: depositphotos.com

The Technion will award the Harvey Prize to three groundbreaking researchers in the field of cancer epigenetics

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Prof. Peter Jones, Prof. Steven Bailin and Prof. Andrew Feinberg will receive the Harvey Award in the field of science and technology for their contribution to the diagnosis of diseases and the development of treatments based on the understanding of epigenetic mechanisms
Evolution of man: display of skulls of our ancestors. Illustration: depositphotos.com

New research may explain why the human brain is so large and developed

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A new study conducted at the Hebrew University of Jerusalem presents an innovative method for inferring DNA methylation patterns in tissues that did not come from ancient skeletons, and provides a deeper understanding of the evolutionary processes that shaped the human brain and its functions
epigenetics. Illustration: depositphotos.com

 Podcast: What is 'epigenetics' and how our emotions affect DNA | In the end it's all a matter of chemistry (chapter 2)

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Tel Aviv 360 podcast of Tel Aviv University. Interviewed, Prof. Yuval Ebenstein (Hebrew only)

Who will win the Nobel Prize in Physics this year? All predictions

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The Nobel Prizes are announced at the beginning of October every year, and about a month before that rumors, predictions and speculations are spread about the identity of the candidates and the chances of winning. In recent years, using innovative data analysis tools, forecasting experts
genetic scan. Illustration: depositphotos.com

Artificial intelligence revealed cancer causes hidden in "junk" DNA

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Research at the University of Sydney suggests that non-coding DNA, which makes up 98% of our genome and was previously considered "junk" – that is, lacking a defined function or redundant, may play a crucial role in cancer diagnosis and treatment.
Chromosomes A Hrefhttps Depositphotoscom Illustration Depositphotoscom A

The silent competition within us: How our organs choose between mom's and dad's genes

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Research conducted by the MRC Medical Sciences Laboratory reveals that cells in different organs selectively express maternal or paternal X chromosomes. This variability, which has been shown in both human data and
Canaanite finds from Megiddo Hill (courtesy of Megiddo Archaeological Expedition)

Researchers have analyzed the genetics of the Canaanites and its relationship to modern populations such as Jews, Palestinians and Bedouins

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The DNA analysis showed that the Canaanites were created from the mixing of populations that migrated to the southern Levant mainly from the Caucasus region (or western Iran) with ancient local populations that stayed there, a process that lasted at least 1,000 years
Histological sections of the leg muscles without injury (left) and five days after it (center, right) in a control mouse and a transgenic mouse. It can be seen that the area of ​​the muscle fibers that develop after the injury is smaller in the transgenic mouse, which indicates a disturbance in the differentiation of the stem cells into muscle cells

overcome the damage

Researchers have discovered that two epigenetic events (removing and adding methyl from DNA) lead to the differentiation of stem cells into muscle cells and thus to the regeneration and healing of muscles after their injury
Mouse brain section. The parts illuminated in red - communication pathways between nerve cells that express the mosquito protein. In blue - the cell nuclei

Mosquito on the head

Weizmann Institute of Science scientists have developed a research tool that will shed new light on communication pathways between nerve cells in the brain
mildew. Illustration: depositphotos.com

The surprising genetic evolution of ancient plants

cancer cell Image: Shutterstock

The memories of a cancer cell

A group of scientists at the Weizmann Institute of Science recently investigated what happens to cellular memory in cancer. Their findings illustrate how "memory loss" may affect the course of malignant diseases
epigenetics. Illustration: shutterstock

Three laws that dictate intergenerational epigenetic inheritance - not through changes in the DNA sequence

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Prof. Oded Ravavi's laboratory previously discovered that worms bequeath to their offspring small RNA molecules that contain information about the parents' environment, such as nutritional status, infection with viruses and even the brain activity of the parents.
The evolution within the evolution. Illustration: Maya Shleifer

The evolution within the evolution

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Diagram of the spatial interaction between the DNA control regions and the controlled genes. The "reporters" (in red and green) reveal these interactions. The laboratory of Dr. Yonatan Stanzler, Weizmann Institute

A cell following its fate

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From the right: Dr. Ronit Nir, Ran Shahar, Miguel Engel Garcia-Campos, Dr. Modi Safra, Dr. Sharit Adelheit-Flor and Dr. Shraga Schwartz. There are many tags in the cell. Photo: Weizmann Institute Spokesperson

The golden tag: How does the m6A chemical tag involved in the control of the human genome work?

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A family tree of worms, based on a neuron (nerve cell), and RNA molecules that transmit information between generations. Credit: Beata Edyta Mierzwa

A mechanism has been deciphered that allows the inheritance of brain activity from generation to generation - not through DNA

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Embryonic stem cell colonies as seen under a microscope: the cells differentiated in an orderly manner when their genome contained a normal copy of the p53 gene (left), but not when p53 was missing (right). Source: Weizmann Institute magazine.

The new role of the guardian of the genome

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Epigenetics - illustration: shutterstock

Researchers from Tel Aviv University have revealed laws that dictate epigenetic inheritance other than through DNA

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Illustration of DNA being transported through a nanometer pore. Courtesy of Prof. Amit Meler, Technion

Beyond the sequence

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A centriole as photographed with an electron microscope. Photo: © Pierre Gönczy/EPF

Beyond genes: do centrioles carry biological information?

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Prayer for the healing of a terminally ill patient. Illustration: shutterstock

About New Age "science".

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identical twins. Photo: shutterstock

What makes some identical twins look different from each other?

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Three chromosomes 21 instead of two in Down syndrome patients. Illustration: shutterstock

Scientists have demonstrated the ability to silence the redundant chromosome responsible for Down syndrome

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An adult fruit fly exposed to an environmental challenge (poison) during its development (left), compared to a fly that developed in a favorable environment (right)

challenges in the environment

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From the right: Alina Molchedsky, Gilad Landan, Naomi Goldfinger, Dr. Zohar Mochmal, Prof. Verda Rutter, Netta Mendelson Cohen, Dr. Amos Tanai and Amir Bar. adolescence

Epigenetics: It all depends on education

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The experimental system: two nostrils from which exit ultrasonic beams of excited helium atoms (in blue) and of argon atoms or hydrogen molecules (in red). The blue beam passes through a magnetic device (in yellow) which causes it to bend, and merges with the red beam - then the argon atoms or hydrogen molecules undergo ionization, and enter the detector. The picture above shows a cross-section of the magnetic device

expression and control

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Chimpanzee and man. From Wikimedia - CC license

The human is "allowed" from the chimpanzee - cancer and autism

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Prof. Haim Sider, Hebrew University

Spotlight: Epigenetics - heredity not only in genes / Dorit Ferns

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Epigenetics, from the website integratedhealthcare.eu

Epigenetics: the hidden switches of the mind / Eric J. Nestler

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A rat in London. Photo: from Wikipedia

Rats exposed to stress during childhood passed on the effects of this early exposure to their offspring

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An autistic boy who arranged his toys in a straight line. From Wikipedia

On the genetics of autism

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Prof. Aharon Chachanover

Who is for life and who is for death

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Stem cells that then differentiate into all cell types

Stem cells with problematic memory

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Agamemnon From Wikipedia

The Genetics of the Trojan War: On Sex, Free Will, and DNA

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Brain parts associated with autism.

Autism: a curable condition?

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A four-legged robot learned to change its movement style to traverse a forest and jump over obstacles

Dr. Erez Brown from the Faculty of Physics at the Technion: first the traits change, then the genes

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A four-legged robot learned to change its movement style to traverse a forest and jump over obstacles

The genome project - success or failure?

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A four-legged robot learned to change its movement style to traverse a forest and jump over obstacles

A new base in DNA may cause a revolution in the field of epigenetics

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A four-legged robot learned to change its movement style to traverse a forest and jump over obstacles

Galileo/Inherited via RNA?

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