aging

SIRT6 reversed signs of aging in the liver of old mice

SIRT6 reversed signs of aging in the liver of old mice

Increased expression of the protein changed chromatin accessibility in the liver of 24-month-old male mice within a month and returned gene activity patterns to a more youthful direction; there is still no evidence that this is a treatment for young people.
A diagram comparing the gradual aging of cells in a tissue and the accelerated aging of a few individual cells.

Not all cells age together: neighboring cells may also be of different biological ages

Researchers from the Hebrew University of Jerusalem have found that cells that age slowly and cells in which epigenetic changes accumulate rapidly coexist within the same tissue. The study, published in Nature Communications, was conducted at the single-cell level.
Tech entrepreneurs and influencers are combining drugs, supplements and experimental treatments in an attempt to slow aging. To date, none of these protocols have been proven to extend the lives of healthy people. Illustration: The News website using AI

Billionaires are trying to “hack” aging – but science has yet to prove that the methods extend life

Tech entrepreneurs and influencers are trying rapamycin, hormones, ketones, plasma exchange and other substances in an attempt to slow aging. Animal studies provide some promising clues, but in-person trials don’t prove efficacy—and some
Israeli study: Repeated cosmetic treatments may take on addictive properties

Israeli study: Repeated cosmetic treatments may take on addictive properties

One in five women in the sample who had undergone cosmetic treatments was at moderate to high risk for a pattern of compulsive use. The factors most strongly associated with this were low body image and problematic use.
Astronaut Scott Kelly and cosmonaut Mikhail Kornienko on the International Space Station. The pair spent 340 days in space as part of a mission designed to study the effects of prolonged spaceflight on the human body. Credit: NASA

Radiation and microgravity caused changes in the liver that resemble accelerated aging in astronauts who spent a long time in space.

Researchers at the University of Central Florida exposed an animal model to simulated microgravity and radiation that simulates deep space travel. The liver showed changes associated with cellular aging, inflammation, and fibrosis. Some of the genetic signatures resembled data from samples
The killifish is an emerging research model for studying the genetic architecture of aging and age-related pathologies, which often exhibit sex-dependent patterns between females (left) and males (right). Credit: Itamar Harel

The gene that speeds up the start of life – and may take a toll in old age

New research led by the Hebrew University points to a gene that demonstrates a rare evolutionary compromise: it aids in rapid growth and early sexual maturation, but may shorten life expectancy and increase the risk of tumors later in life.
Sleep test in a laboratory. Illustration: depositphotos.com

Not just snoring: Obstructive sleep apnea damages muscles

Researchers at Ben-Gurion University and Soroka have found a significant link between obstructive sleep apnea and a decline in skeletal muscle quality, in addition to a previous link to a decline in bone density. The findings may aid in the early detection of
Increasing life expectancy. Illustration: depositphotos.com

Life expectancy is more hereditary than we thought: Study in Science suggests about 50% genetic influence

New mathematical model and analysis of twin databases from Sweden, the United States and the United Kingdom separate “external” mortality from aging – and double previous estimates
Greenland shark. From the study Nature Communications, 17(1), 39. https://doi.org/10.1038/s41467-025-67429-6

Greenland shark retains sight for centuries. Possibly with DNA repair

A study in Nature Communications found adaptations for low-light vision and hints at maintenance mechanisms that prevent retinal degeneration in extreme old age. However, despite the evolutionary and environmental distance, it may be possible to learn something about the preservation of vision in humans.
Microscopic photograph: In the top row - a photograph of the brain of a normal fly, and in the bottom row - the brain of a fly with neurodegeneration, showing holes in the brain. Credit: Shai Kloksi

An enzyme that prevents sleep and mood disorders

The researchers showed that a deficiency in SIRT6 (which declines with age) diverts tryptophan into the neurotoxic kynurenine pathway at the expense of serotonin and melatonin production; inhibiting the enzyme TDO2 in fruit flies reduced brain damage and neuromotor deterioration. The findings were published in Nature

A leap in body rejuvenation: Engineered stem cells and exosomes restored many systems in macaque monkeys

Dr. Roy Tsezana, former principal investigator at XPRIZE for aging, talks about the $101M competition to rejuvenate humans — and new research that rejuvenates cognition, immunity, and bone in monkeys, reduces senescent cells, and turns back “age clocks” by 5–7 years
A sample from a tumor of a human patient with the most common lung cancer (adenocarcinoma). The presence of senescent cells expressing the proteins P16 (in red) and PD-L1 (in green) can be detected. The cell nuclei in the sample are marked in blue

to open blockages in the immune system

Photomicrograph of a biopsy from a patient's lungs. Illustration: depositphotos.com

Towards a new generation of treatments for old age diseases

A researcher examines a killifish fish. The image was prepared using DALEE and is not a scientific image

Cracking the code for longevity? A breakthrough in understanding the relationship between sex and life expectancy

A study by Hebrew University researchers opens innovative avenues in understanding the influence of sex cells on life expectancy and sheds light on the central role of sex cells and fertility on longevity
Smoking and ultraviolet radiation end the effects of aging. Credit: The Science website via DALEE

The cause of aging: cumulative damage from factors such as radiation and smoking causes low expression of long genes

Dutch researchers found that this process happens all the time and damages all genes, but the longer the genes, the more likely they are to be damaged because they have more sites. Especially the big damage is
What is needed to prolong life. Illustration: depositphotos.com

A new competition to stop aging with prizes of 101 million dollars

A new competition to stop aging with prizes of 101 million dollars
blind rat Illustration: depositphotos.com

Build muscle and stay young

Researchers have discovered that the skeletal muscle composition of the blind rat is preserved throughout its life, delaying its aging
The colonies of a unique marine creature age in their entirety, rejuvenate again - and God forbid. Botrill flower, photo: Dr. Osherat Ben-Hamo

Phoenix of the sea

The animal that breaks the laws of nature: a new Israeli study reveals that the colonies of the flower botryll, a unique marine creature, age in their entirety - and then return to being young again. The phenomenon was named "Orshina Rhythm"
Urban bat (photo: Yuval Barkai)

Bats also lose their hearing but the process happens in a moderate way in relation to their noisy living environment

Two surprising discoveries: contrary to the popular hypothesis, bats do suffer from hearing loss with age, but they apparently have surprising mechanisms that help them slow down the rate of hearing loss
grow old. Illustration: depositphotos.com

Age slowly, live longer

A study in C. elegans worms found that a type of small RNA molecule is essential for slowing the rate of aging and prolonging the lives of animals with a damaged reproductive system
African killifish. Illustration: depositphotos.com

delay the diseases of aging

On aging fish, folding proteins and a new route for the development of medicinal substances
old age Image: depositphotos.com

About the bitter and the sweet in her old age

Is it happy to grow old? And how to grow old? Can the way we perceive old age be changed for the better? Prof. Ehud Bodner from the master's degree program in gerontology, answers these questions: Is it happy to grow old? and how
Intelligence from artificial intelligence and the study of old age. Corona virus. Illustration: depositphotos.com

Using artificial intelligence to find compounds that inhibit aging

Researchers from the University of Surrey have developed an artificial intelligence model capable of identifying chemical compounds that promote healthier aging - paving a possible path towards pharmaceutical inventions that could extend the lifespan of
Dr. Deborah Tober. Photo: Danny Machlis, Ben-Gurion University of the Negev.

Scientists have been able to identify the genes that influence a healthier aging process

Researchers from Ben-Gurion University of the Negev are leading innovative research on understanding the molecular processes in the aging process and have found genes that can predict healthy aging and help prevent diseases
Happy aging. Illustration: depositphotos.com

About aging - and the research that may show how to stop it

Many theories have been proposed in the past - and are still being proposed - as a way to explain the phenomenon of aging. In recent years, a new theory has been added to them that explains aging. Seemingly, there is nothing new in this, but really
Pressure chamber in a hospital. Illustration: depositphotos.com

Forever young?

The world's first clinical trial of its kind, conducted by researchers from Tel Aviv University and Shamir Hospital (Assaf Harofeh), states that pressure chamber treatment of healthy elderly people can stop the
From right to left: Anatoli Meler, Flonia Levy-Adam, Tahani Kedah, Reot Shelgi, Amal Younis, Shani Hadar and Kinneret Rosales-Shergenheim. Photo: Rami Shloush, Technion speakers

For the first time, a study reveals the decline of the protein control system with aging

The research published in PNAS - the journal of the National Academy of Sciences in the United States - was led by Prof. Reut Shelgi, research colleagues Niv Sabat and Falonia Levy-Adam and doctoral student Amal Younis from the Faculty of Medicine
A dog and its elderly owner. Illustration: shutterstock

Dog age in human years: Why does breed change the calculation?

Labradors, bulldogs, and mastiffs do not age at the same rate. What does the data by breed teach us, and why is there no fixed ratio between dog years and human years?
A significant decrease in the number of senescent cells (blue spots) in the liver and lung tissues of mice following the drug treatment

Forever young - the lab version

Prof. Hiroshi Ishiguro the human (right) and his robot double (left). Source: Florian Voggeneder / Ars Electronica.

"When the population is aging, there is no choice but to use robots"

Image: pixabay.

Mysterium - live forever / Tal Rashef

Exposure to chronic air pollution is equivalent to two years of accelerated aging in terms of cognitive ability. Photo: Wiebrig Krakau.

Aging in a polluted world

Photomicrograph of senescent cells in a mouse - cells that "retire" and stop dividing, but do not die - are always present and even play some important roles in the body, for example in wound healing. But in aging organs, these cells are not eliminated at the proper rate, and can accumulate and damage Source: Y tambe, Wikimedia.

Get rid of old hair

Source: pixabay.com.

Questions for the future of humanity: Will we defeat aging?

up the ascending stairs

Antiaging medicine. Image: iQoncept/Shutterstock

Health sciences - can we stop aging? / Karen Weintraub

Liver cells at high magnification. Photo: shutterstock

A sign that you are young

A Lithuanian elderly couple in a folk dance. From Wikipedia.

Why does our hair bleach and how do we restore its color?

Armond Marie LeRoy's book, with a whole chapter on the aging process

Stop Death Chapter 2: The Evolution That Killed Me

Fred Meyer supermarket.

To stop death - part three: the hunger for life

elders. From Wikipedia

with a good pull

Joshua Sens and Jeff Lichtman

How calorie restriction and exercise inhibit several aging effects