Zebra fish

A Mexican axolotl in the regeneration lab of biologist Josh Curry of Wake Forest University. Credit: Wake Forest University

New study points to genetic pathway for organ regrowth

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Identifying genes shared by different animals opens the door to developing gene therapy treatments that will enable limb reconstruction in humans in the future.
Five-day-old zebrafish embryos under a microscope: the normal embryo (top) and the transgenic embryo (bottom) carrying the gene with the disease-causing mutation. It can be seen that in the transgenic embryo the main lymphatic vessel is abnormally enlarged

From the clinic to the aquarium: New zebrafish-based drugs for a rare lymphatic disease

A unique collaboration between the Weizmann Institute of Science and Sheba Medical Center led to the discovery of two potential drugs for a life-threatening disease of the lymphatic system.
The list of crystals in the zebrafish: in the gill covers (top row) - long and narrow crystals, in the eye of the fish (middle row) shorter crystals, and in the skin (bottom row) - the shortest

The animals' secret recipe book for creating colorful and versatile crystals has been revealed

Fish trip. Figure: The knowledge site using DALEE. The image is for illustration only and should not be considered a scientific image

Fish trip

The institute's scientists have developed a method for detecting the neurological effects of psychedelic drugs. Middle: Zebrafish on hallucinogenic mushrooms. The goal: to pave the way for more effective treatments for depression and other mood disorders
The pituitary gland of the zebrafish. The variety of cell types are marked in different colors: in purple - phytocytes, in red and green - two types of hormone-producing cells

Where does the fish secrete from: back to the origins of the pituitary gland

Weizmann Institute scientists are challenging a 200-year-old doctrine about the formation of the gland from the secretion of hormones. Their findings may lead to new approaches in the treatment of various medical problems
Zebra fish. Image: depositphotos.com

Thanks to the study of zebrafish, researchers have identified a mechanism that explains fertility problems in humans

University researchers have identified a new type of organelle that has not been discovered in gametes before. According to them, a failure in its function causes infertility because it is responsible for the organization of the chromosomes in the sex cells: "The discovery advances us towards finding
A group of zebra fish in an aquarium. Illustration: depositphotos.com

Someone to swim with

How do zebrafish know how to swim in groups?
Prof. David Sheprincek and research student Udi Binstock from the School of Neurobiology, Biochemistry and Biophysics at Tel Aviv University. PR photo

A new study on the brain of zebrafish has proven that new neurons are formed in the brain in an orderly and coordinated manner

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The researchers found that the activation process of stem cells in the brain responsible for the production of neurons (nerve cells) is not random but ordered and coordinated. According to them, the findings are of great importance for understanding the normal development of the brain.
Cross section of the zebrafish heart 30 days after injury. The injured site (marked by an arrow) without a scar in a fish with normal lymphatic vessels (left) but not in a mutant fish that does not have these vessels (right)

heart of a fish

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Dr. Takashi Kawashima and Dr. Mio Nonke. Photo: Weizmann Institute Spokesperson

The fish will play before us

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The hormone oxytocin (in purple) at the secretion points in the synapses (in green) in the transparent brain of a genetically modified zebrafish. Prof. Gil Levkovitch, Weizmann Institute

the love bubble

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The triumvirate of the neurohypophysis: phytocytes (in purple) scattered between the ends of axons (in green) and blood capillaries (in red)

Discovery: how certain blood vessels in the brain open "windows" that allow the blood-brain barrier to be overcome

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Close-up of a zebrafish eye. A sophisticated and accurate vision system

A look at the fish's eye

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Zebrafish brain imaging results. Left: Optical fluorescence microscopy imaging provides only a blurred image limited to the surface. Right: The optoacoustic FONT approach, on the other hand, provides a high-resolution XNUMXD image and detailed information on the activity of the neurons (orange dots) in real time, all over the brain. Photo: Helmholtz Center, Munich.

A window to the depths of the mind

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The endothelial cells, which make up the blood vessels of the zebrafish embryo (in red). The cell nuclei are marked in yellow. The stem cell pool is marked with an arrow

Wandering with gut feeling

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From the right: Dr. Karina Yaniv, Guy Melkinson, Inbal Avraham-Davidi, Moshe Greenspan, Liron Gibbs Bar, Oded Meisels and Yona Eli. Dialogue. Photo: Weizman Institute

Dialogue in the dark

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