Salmonella

Stem cells in the gut sacrifice themselves to stop bacterial infection

A study by the Weizmann Institute and the Hebrew University reveals a new immune defense mechanism: stem cells infected with Salmonella accelerate their maturation, stop reproducing, and help save intestinal tissue.
Couple therapy of bacteria. Weizmann Institute illustration

in couples therapy

Figure - on the left: the atomic structure of the protein segment that forms the biofilm fibers in E. coli and Salmonella. This structure is very similar to the structures of amyloid fibers associated with Alzheimer's disease, and this structural similarity led to the idea of ​​damaging the bacterial biofilm fibers using the substances developed against Alzheimer's fibers. Above (in black and white): images taken with an electron microscope. On the left are visible fibers that are formed by the bacterial protein and are used to build the biofilm; On the right is shown the damage to fiber formation as a result of the addition of the substance that opens Alzheimer's fibers (ANK6) Below (in black-red): 6D images taken with a confocal microscope after red fluorescent staining of the bacterial biofilm. Left: high density of biofilm; Right: a significant decrease in the amount of biofilm following the addition of the substance ANKXNUMX.

Scientists at the Technion succeeded in damaging the defense mechanism of salmonella bacteria using substances originally developed against Alzheimer's disease

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