Cancer research

Section of breast tissue from a triple negative breast cancer (TNBC) patient, on the right, and healthy breast tissue, on the left. In the cancer patient, the cancer cells (indicated in light blue) surround cells in their microenvironment that express a high level of CD84 (indicated in purple)

burn the bridges of cancer

The institute's scientists revealed how aggressive breast cancer disrupts the immune response against it, and developed a treatment using an antibody that may be suitable for many types of cancer
Comparing the effects of fasting on the health of the digestive system. The image was prepared using DALEE and is not a scientific image

Intermittent fasting: health benefits alongside an increased risk of cancer

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immunotherapy. Illustration: depositphotos.com

Faster, stronger

Weizmann Institute scientists have developed a new approach to increase the rate of division of immune cells in the laboratory, while preserving their ability to kill cancer cells, and have identified optimal time windows in which the cells are particularly lethal. The method may promote
The astronauts of Polaris Dawn put on the special space suits developed by SpaceX and designed for an environment saturated with radiation before the launch. Photo: NASA/SPACEX

Historic launch: SpaceX's Polaris Dawn mission in which the first private spacewalk is expected

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Lung cancer. Illustration: depositphotos.com

Research at the Faculty of Biology at the Technion paves the way for innovative lung cancer treatment

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genetic scan. Illustration: depositphotos.com

Artificial intelligence revealed cancer causes hidden in "junk" DNA

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Research at the University of Sydney suggests that non-coding DNA, which makes up 98% of our genome and was previously considered "junk" – that is, lacking a defined function or redundant, may play a crucial role in cancer diagnosis and treatment.
A researcher examines a killifish fish. The image was prepared using DALEE and is not a scientific image

Cracking the code for longevity? A breakthrough in understanding the relationship between sex and life expectancy

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A study by Hebrew University researchers opens innovative avenues in understanding the influence of sex cells on life expectancy and sheds light on the central role of sex cells and fertility on longevity
Personalized Medicine Illustrated: depositphotos.com

The discovery that will advance personalized medicine for infectious diseases

This is the first time that researchers succeed in developing personalized tools for infectious diseases, which until now have only been developed for specific diseases such as cancer and Alzheimer's
Prof. Yitzhak Weitz. Photo: Tel Aviv University

Prof. Yitzhak Weitz won the Saint-Georges Prize for the promotion of cancer research for 2023

His important contribution included a host of breakthrough insights and discoveries, publications and collaborations in the field of cancer research
A new study by Prof. Ofra Bani from the School of Pharmacy at the Hebrew University of Jerusalem and Dr. Sharon Marims - dermatology specialist and senior physician at the dermato-oncology clinic at the Hadassah Medical Center and the Hadassah Cancer Research Institute, published in Science Translational Medicine courtesy of the Hebrew University

A new way to solve side effects of cancer treatment

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Researchers at the Hebrew University and the Hadassah Medical Center have developed an ointment to treat the severe side effects of targeted cancer treatment and significantly improve the quality of life of patients.
Photo: depositphotos.com

Artificial intelligence in the service of cancer medicine

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A technology based on artificial intelligence may quickly and simply decode genetic and molecular information about cancer tumors. On the horizon: personalized medicine for cancer patients
The chemotherapy treatment increases the secretion of LOX from T cells, and as a result the extracellular environment in the lungs changes in a way that encourages the formation of metastases. Photo: Technion spokespeople

Cancer metastases sometimes form following successful chemotherapy treatment

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Cancer treatment. Illustration: depositphotos.com

Break the boundaries of immunotherapy

The method that may make the new generation of cancer treatments accessible to more patients
Bacteria (in green) establish a home in cancer cells and settle comfortably in the cell nucleus area. Source: Weizmann Institute

Cell within a cell: the bacteria that live inside cancerous tumors

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Prof. Gideon Ravavi, Head of the Cancer Research Department at the Sheba Medical Center. PR photo

Israel Prize in Medical Sciences to Prof. Gideon Ravavi of Shiba, head of the "Genome-Based Hospital" program

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Blood test to detect the risk of lung cancer. Hekra and Ira - Dr. Tamar Paz-Elitzur

The smoking gun of DNA

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Cancer cell genome. Illustration: shutterstock

Biomarkers that may predict the chances of success of cancer immunotherapy

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Dr. Itai Tirosh and Julie Lafi. The most common and violent brain cancer

Against four cells - why is there currently no effective drug for the treatment of glioblastoma brain cancer?

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Lungs of an untreated mouse with Ewing's sarcoma (left) containing many cancer cells (highlighted) that have spread from the bones, compared to almost completely clean lungs of a mouse treated with a drug that reduces glucocorticoid production (right)

The causes of the spread of bone cancer were revealed in Ewing's name

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Prof. Lucio Friedman. Photo: Weizmann Institute Spokesperson

It is possible to "watch" brain metabolism using MRI

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The cells labeled with fluorescent dyes in the primary tissues of the wing (left), eye (center) or leg (right) in the fruit fly larva, do not migrate when they have normal caspase activity (top row). When the caspases are removed, these cells begin to migrate after irradiation to other parts of the tissue (bottom row)

What happens when the mechanism for programmed cell death is removed from the cell

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Fighting the most violent cancer that has no cure

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Dr. Ayelet Erez. Photo: Weizmann Institute of Science Spokesperson

A new option for cancer detection: detection of disturbance in nitrogen metabolism

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Illustration of the dual roles of caspase-3 - cell death and cell division - on the cover of Molecular Cell, courtesy of the journal

Researchers have uncovered the complex role of the caspase-3 protein in cancer * a way to a new therapeutic approach

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Medical crystal ball: a new method for selecting chemotherapy treatment

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Computing in medicine. Image shutterstock

How do you reduce the transfer time of genomic data from six years to a few months?

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Cytotoxic T white blood cells (in red) attack a cancer cell. Illustration: Elena Serda, Duncan Comprehensive Cancer Center at Baylor College of Medicine, National Cancer Institute, National Institutes of Health.

A new treatment eliminates cancerous tumors of various types throughout the body

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Cancer cells, illustration. Source: National Cancer Institute.

Not all cancer cells are created equal

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Aspirin has been found to be effective in the treatment of various diseases. Evidence shows that it can also prevent the formation of malignant metastases. Illustration: Jill Watson.

Aspirin against cancer

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The mystery has been solved: why a small percentage of pancreatic cancer patients survive much longer than others

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Metastatic melanoma cells. Illustration image. Source: National Cancer Institute.

The central role of the sherpin protein in the development of cancerous tumors has been revealed

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Illustration: K. Raskoff, Monterey Peninsula College, Arctic Exploration 2002, NOAA.

The hunt for cancer cells inspired by the jellyfish

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In the future, will lung cancer patients be able to receive chemotherapy using an inhaler at home? Source: illustration - Nic McPhee.

Inhaled chemotherapy for lung cancer

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Cancer metastasis in the brain, originating from lung cancer. Photo: Marvin 101, Wikimedia.

Two genes responsible for the development of brain metastases among lung cancer patients have been identified

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Illustration: The Trojan horse represents the virus, which enters the cell and causes the creation of proteins. Their purpose is to call the immune system, so that it attacks the cancer cell only, without harming healthy cells. Source: Courtesy of the Hebrew University.

Researchers have developed a "switch" that activates the immune system to attack cancer cells when it detects signs of the disease

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Hepatocellular carcinoma liver cancer. Source: Ed Uthman.

New liver cancer research reveals potential targets for treatment

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The attached images show how E260 dramatically affects the mitochondria of metastatic cells. From the study.

Researchers have developed a substance that kills cancer metastases without harming normal cells

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Bacteria (in green) inside pancreatic cancer cells (AsPC-1 cells). The nuclei of the cells are colored in blue and the intracellular fluid in orange. Source: Weizmann Institute magazine.

Fifth brother-in-law: bacteria that live inside cancerous tumors disrupt the drug treatment

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CAR T cells attack a cancer cell. Source: Rita Elena Serda, Duncan Comprehensive Cancer Center at Baylor College of Medicine, National Cancer Institute, National Institutes of Health.

The army to destroy cancer

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Fluorescent actin fibers. Produce rounded folds on the cell membrane. Source: Weizmann Institute magazine.

Reshaping the surface: wave fronts create folds in the cell membrane

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Embryonic stem cell colonies as seen under a microscope: the cells differentiated in an orderly manner when their genome contained a normal copy of the p53 gene (left), but not when p53 was missing (right). Source: Weizmann Institute magazine.

The new role of the guardian of the genome

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Cancerous breast cells (in blue). Source: NIH.

Researchers were able to reduce the risk factors for the spread of cancer metastases after resection of the primary tumor

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leukemic cells. Evolve from "cancer stem cells". Photo: Mary Ann Thompson / Wikimedia.

Is it possible to identify, already in the initial diagnosis, signs that the cancer is going to return?

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Prototype of the Watson system, 2011. Photo: Clockready / Wikimedia.

Watson set a record in analyzing the genetic makeup of cancer patients

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The area of ​​operation in the peritoneal membrane of a mouse. The red marking shows the expression of LOX; The green marking shows the hypoxia (lack of oxygen) in the cells. Source: Courtesy of the Technion.

Battle of Lima

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waves in the cell membrane. Source: From the study - Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles.

Researchers shed new light on the movement of waves across cell membranes, which may affect cancer research and treatment

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Dr. Ayelet Erez. Photo: Weizmann Institute of Science Spokesperson

The connection between a rare childhood disease and the fight against cancer

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Photomicrograph of senescent cells in a mouse - cells that "retire" and stop dividing, but do not die - are always present and even play some important roles in the body, for example in wound healing. But in aging organs, these cells are not eliminated at the proper rate, and can accumulate and damage Source: Y tambe, Wikimedia.

Get rid of old hair

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Schematic diagram of the system and the DNA molecules conjugated to a synthetic molecule that pulls them through the hole. Right: an example of the optical signal (in two colors) indicating the level of methylation. Courtesy of the Technion.

Unimolecular cancer diagnosis

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Diagram from the article, which presents the innovative method developed: "We pack tiny amounts of the anti-cancer drugs inside dedicated nanoparticles that we developed. The uniqueness of these nanometer packages is that they flow in the bloodstream to the tumor and there are swallowed by the cancer cells. To these packages we attach "In advance, artificial DNA sequences are used as barcode readers of the drug's activity in the cancer cells. After 48 hours, a sample (biopsy) is taken from the tumor, and the barcode analysis provides accurate information on the cells that were destroyed (or not) by each drug." Source: Zvi Yaari et al., Theranostic barcoded nanoparticles for personalized cancer medicine, Nature Communications 7, 2016.

Personalized medicine for cancer treatment

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