Antibodies

Immune system memory cells may help in long-term fight against ovarian cancer

A study from the Weizmann Institute of Science reveals that memory cells of the immune system do not only work against viruses and bacteria. In women with ovarian cancer, memory B cells were found that are able to reach the tumor and produce antibodies.
Breastfeeding. Illustration: depositphotos.com

It's all thanks to mom: Babies "recycle" antibodies from the mother into saliva: A new mechanism keeps the mouth protected even between feedings

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Hebrew University study suggests that infants actively transfer maternal IgG antibodies to the salivary glands – thus protecting the oral cavity and tuning the immune system early in life
Dr. Natalia Freund. Photo: Tel Aviv University Spokesperson

A long and winding journey to discover new ways to fight tuberculosis

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A study from Tel Aviv University identified two families of human antibodies that bind to the PSTS1 protein of the tuberculosis bacterium, and in a mouse experiment, the antibody treatment led to a 50% reduction in the bacterial load in the lungs.
Dr. Ohad Waneshk and the biochip. Photo: Weizmann Institute Spokesperson

The biochip that is already ready for the next pandemic

A new DNA chip from the Weizmann Institute of Science produces dozens of viral antigens on silicon in a single experiment and rapidly maps the immune “fingerprint” of subjects – a tool that could accelerate the development of tests, vaccines,
Prof. Pamela Bjorkman wins the 2025 Wolf Prize in Medicine. Photo: Wolf Prize Foundation

Wolf Prize in Medicine 2025: Recognition of Prof. Pamela Bjorkman for her pioneering contributions to the understanding of viral defense mechanisms

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Prof. Pamela Bjorkman from the California Institute of Technology won the prestigious award for developing innovative antibody-focused approaches to combat viruses and establishing an infrastructure for advanced vaccine research.
Histological section of the nasal cavity and turbinates of a mouse that received a nasal vaccine

The immune cells discovered under the nose

The scientists of the Weizmann Institute of Science have discovered antibody-producing cells in the bone tissue of the nasal concha and thereby plant hope for the development of more effective nasal vaccines and new treatments for allergies and neurological and autoimmune diseases
Antibody engineering. Illustration: depositphotos.com

humanize the messenger

An algorithm developed by the institute's scientists heralds a leap forward in the field of humanizing antibodies and may enable the rapid, efficient and cheaper development of new drugs. The key: stability
A segment of the lymph node. Illustration: depositphotos.com

New information about phagocytic cells of the immune system may lead to treatments for incurable autoimmune diseases

The origin of the mysterious macrophages, known in scientific language as Tingible Body Macrophages (TBM), originates from progenitor cells of the blood system that emerge from the bone marrow and settle in the lymph nodes, where they quickly and efficiently digest cell remnants
A niche inside a lymph node where the antibody-producing cells are formed. The laboratory of Prof. Ziv Shulman

Learn from the body to neutralize the corona

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fight against corona virus Illustration: Image by Fernando Zhiminaicela from Pixabay

Identifying a trap and finding the ultimate anti-coronavirus

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The active part of the molecule "Erncept" (threads in the colors of the rainbow) binds to the receptor of the Machupu virus (in gray). honey trap

A molecule that effectively neutralizes deadly viruses that pass from animals to humans

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Early detection of cancer. Illustration: Image by Mohamed Hassan from Pixabay

A nanotechnological biochip for detecting minimal levels of disease markers

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Illustration of a primary Cornell spot (left) attached to an antibody fragment (center) while binding to the HER2 cancer cell receptor (right). The dot and the antibody attached to it together are less than 8 nanometers in diameter, the size threshold for removal from the body by the kidneys.

An effective weapon to fight cancer - antibodies

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Cell T (in red) selects cell B (in blue) for the "training camp". In green - B cells lacking ICAMs. Photographed using a two-photon laser scanning microscope. Source: Weizmann Institute magazine.

Corrective immune discrimination

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Comparison between computer models (in green) and experimental structures (in purple). Accuracy at the single atom level in both the overall structure (left) and the loop segments (right). Source: Weizmann Institute magazine.

A computerized method for the production of artificial proteins

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Tiny silk capsules that resemble silkworm cocoons may be used to transport antibodies and drugs

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Super antibody against bacteria. Illustration: The Hebrew University.

A breakthrough immunological approach targets the person instead of the bacterium

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Vaccination. Illustration: shutterstock

Signs of whooping cough / Tara Hal

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Monoclonal antibodies to cancer

Drugs delivered to cancer cells using antibodies

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A model of a bNAb antibody. The binding sites are seen in light blue, the areas prone to mutations in pink

Map the crystal structure of antibodies to the AIDS virus

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And plastic artificial testicles like the ones pictured below are capable of fighting everything from viral infection to allergens in the bloodstream. Photo: University of California at Irvine

Plastic antibodies are able to fight antigens in the body like real antibodies

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Cosmic scene with DNA, stars, solvents and atomic circles in oral flow.

Synthetic substitutes for antibodies

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Cosmic scene with DNA, stars, solvents and atomic circles in oral flow.

How to take advantage of the antibodies' ability to recognize foreign molecules

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