Aging cells

A sample from a tumor of a human patient with the most common lung cancer (adenocarcinoma). The presence of senescent cells expressing the proteins P16 (in red) and PD-L1 (in green) can be detected. The cell nuclei in the sample are marked in blue

to open blockages in the immune system

Transient aging: Zebrafish (top row), newborn mouse (middle row) and adult mouse (bottom row) hearts are seen (left column) with almost no senescent fibroblasts (indicated in turquoise). After injury to the heart muscle (accompanying agrin injections in an adult mouse), many fibroblasts went into a state of senescence (middle column), which passed about three weeks later (right column)

Aging cells, young heart

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