A sturdy faction

Photomicrograph: the density of green-red-purple colors indicates the existence of hybrid cells at the tendon-muscle interface. In green - the muscle fibers; In red - LOXL3 RNA is expressed in tendon and tendon-muscle junction. LoxL3 is an enzyme found at the ends of the developing muscle fibers and is responsible for building the muscle tendon junction. In purple - MyoD RNA is expressed within the muscle itself. MyoD is a gene responsible for muscle cell differentiation. Photo courtesy of the Technion Spokesperson

How are inter-tissue interfaces formed?

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Researchers at the Rappaport Faculty of Medicine at the Technion discovered that the connection between tendons and muscles is formed by hybrid cells that merge with the muscle fibers and "know" how to cause the ends of the muscle to express tendon characteristics
Diagram of the "docking plan" of the muscle fibers. Left: the chain process leading to the normal development of the muscle-tendon interface. Right: A malfunction in this process leads to a disruption in the formation of the interface. Illustration: The Technion

A muscle is born

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