P53

The mechanism that allows breast cancer to metastasize to the brain has been deciphered. Courtesy of the researchers

For the first time, a mechanism that allows breast cancer to metastasize to the brain has been deciphered

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Researchers from Tel Aviv University have identified a link between loss of p53 activity (and sometimes deletions in the short arm of chromosome 17) and the adaptation of breast cancer cells to the brain environment through fatty acid pathways and communication with
Tumors in the mammary glands of mice under a microscope: tumors in which the LATS1 gene is missing develop characteristics of basal breast cancer (left); Tumors lacking the LATS2 gene have luminal characteristics and metabolic changes (right)

Who will keep the guard

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Senescent cells (top) and normal cells (bottom) from the inner lining of a mouse lung, stained with colors that highlight the markers of aging (left) or the characteristics of the lining (right). Filmed with ImageStreamX technology. Source: Weizmann Institute magazine.

Inventory count of senescent cells

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Embryonic stem cell colonies as seen under a microscope: the cells differentiated in an orderly manner when their genome contained a normal copy of the p53 gene (left), but not when p53 was missing (right). Source: Weizmann Institute magazine.

The new role of the guardian of the genome

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proteins inside the cell. Image: Courtesy Nicolle Rager and National Science Foundation

Scissors for removing proteins

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Melanoma cells. Photo: shutterstock

The characterization of the different types of skin cancer (melanoma) will enable the development of personalized treatment

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The interaction between the proteasome and NQO1 is based on mutual inhibition: the proteasome breaks down unstructured NQO1 enzymes (which are not bound to FAD), while the enzyme, when bound to FAD, prevents the proteasome from breaking down other proteins - including itself

Save the lifeguard

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From the right: Dr. Rachel Sarig, Alina Molchadsky, Dr. Ariel Rinon, Dr. Eldad Tzahor and Prof. Varda Rotter. Rewiring

added to his role

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From right: Prof. Moshe Oren, Prof. Varda Rotter and Dr. Perry Stambolsky. Photo: Weizmann Institute

Thirty years since the discovery of the P53 gene

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