CFTR

Human cells that have undergone gene editing using a novel retron-based gene editing technology. The orange dots indicate successful gene edits. The green dots show a fluorescent protein tag on the surface of mitochondria. Credit: Yu-Cheon Chang / The University of Texas at Austin.

New retron-based DNA editing method to replace CRISPR offers hope for broad treatment of complex genetic diseases

Researchers at the University of Texas at Austin have developed a gene editing technique that can replace damaged DNA segments in their entirety, simultaneously correct a variety of rare mutations, and achieve an efficiency of about 30% of target cells – with initial applications