free radicals

Mutation in RBM6 may make cancer cells more sensitive to cisplatin

The defect that makes it difficult for cancer cells to repair themselves – and increases their sensitivity to chemotherapy

Researchers at the Technion discovered that the protein RBM6 participates in the repair of double-strand breaks in DNA. In experiments in cells and mice, damage to the gene that produces it increased the sensitivity of breast tumors to the chemotherapy drug cisplatin.
Neurons in rat brain and in culture after treatment with AAV vectors

On-demand gene therapy reduced seizures in rats with epilepsy

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Researchers from the Hebrew University and University College London have developed an antioxidant therapy based on AAV vectors. The therapeutic sequence is activated in response to abnormal electrical activity in the brain. More than half of the treated rats were free of seizures, and the remaining animals
Diagram of the structure of mitochondria. Illustration: depositphotos.com

When the cell's energy station goes wrong

Researchers from the Hebrew University have identified a neural network that works against the feeling of reward – and offer a new therapeutic approach to dealing with drug addiction by regulating emotional pain during withdrawal.
Women support breast cancer awareness using the pink ribbon symbol. Illustration: depositphotos.com

To put the cancer to sleep

Weizmann Institute of Science scientists reveal how breast cancer cells enter dormancy, how it is maintained over years – and why they suddenly awaken and form metastases
Right: the opening (red) of the phagophore (green) remains narrow thanks to the coordinated activity of two protein clusters. Left: The opening widened after the scientists reduced the action of the valve that is responsible for closing it

open a little mouth

This is how you maintain a balanced diet of the autophagy organs - the self-eating mechanism in our body cells that removes waste and strengthens our health
Mitochondrial transplantation in cells whose mitochondrial function is impaired. improves their function and saves them from death. Dr. Ziv Rothfogel from the Hebrew University of Jerusalem

save the retinal cells

How can cells in the retina that have been damaged by lack of blood supply be restored? Mitochondrial transplantation contributes to the survival of damaged neurons in the retina of mice
The nightshade uses a complex defense mechanism to ward off unwanted eaters - but gives the bulbul a "secret trick" that allows it to enjoy its fruits and spread it further. Photo: Gil Kopilevitz

Protection from the plant

A new Israeli study reveals that the desert gorse, a common plant in the country, releases a pungency that prevents many animals from eating it - but gives the bulbul birds a "medicine" that helps them digest its fruits. And: how
Breast tumors that were treated with the drug cisplatin (second and fourth row) compared to tumors that were not treated this way (top and third row)

Repairing the cancerous growth

The creation of double-strand breaks in the DNA of certain cancer cells may help inhibit the growth
The structure of the binding site for copper ions (in red) in the mucin molecule

A close and slippery escort: is our mucus involved in the body's metabolism?

The scientists of the institute discovered a surprising involvement of the intestinal mucus in the absorption process of copper - a metal that, like iron and zinc, is necessary for our bodies, but can be dangerous.
balding. Image: depositphotos.com

The artificial intelligence that regrows hair

Chinese researchers used artificial intelligence to scan combinations of metals and elements and identify compounds that would break down the free radicals that damage hair follicles
The process of telomere shortening with each cell division. Image: depositphotos.com

A new and natural mechanism for lengthening telomeres has been discovered

Amlek - Scientists have identified a new mechanism that slows down and may even stop the natural aging process of the cells of the immune system
Height differences between humans. Image: depositphotos.com

Things that Yoram knows: Is it healthy to be tall?

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DP asks: Big dogs live less than small ones, so how is it that taller humans are healthier?
AMI gate and on it the study about the production of melanin in the laboratory. Courtesy of Tel Aviv University

Researchers were able to produce the biological substance melanin for the first time under laboratory conditions

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The results of the research by a team led by female researchers from Tel Aviv University showed that with the help of the new technology that the researchers developed, it is possible to control the production process of melanin in the laboratory, and obtain a pigment similar in its properties to biological melanin
Prof. Haim Pick and Meirav Har-Even Kerzhner. Photo: Tel Aviv University

Have you had a traumatic brain injury? A ketogenic diet will reduce the damage

It was found that the popular diet improves spatial memory and visual memory, lowers inflammation indices in the brain, reduces neuronal death and slows the rate of cellular aging
The corona virus developed in bats. Illustration: shutterstock

The outbreak of the corona virus raises a question: why are bat viruses so deadly?

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Algal cells respond in different ways to the same stress conditions. Illustration: Prof. Assaf Vardi's laboratory, Weizmann Institute

survival of the few

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Octopuses have the ability to control the lens of their eye, in a way that allows them to see well in both air and water. Photo: Qijin Xu - Unsplash

hide like an octopus

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radiation. Illustration: shutterstock

Can exposure to low-dose ionizing radiation be healthy for us?

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algae. It still needs to be proven that platinum protects the human skin even outside the sterile laboratory. Photograph: Gugulethu Mhlanga.

Is the sunscreen of the future hiding in algae?

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MRI scan of an ALS patient. Source: Frank Gaillard, Wikimedia.

New drugs for ALS are on their way to clinical trials

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Image: pixabay.

Mysterium - live forever / Tal Rashef

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Population genetics. Figure: US Institutes of Health NIH

Evolution has not stopped - humans are still developing

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A diagram describing the beneficial properties of hemoglobin wrapped in a polydopamine type polymer - an antioxidant, releases oxygen molecules and protects against oxidative stress.

Artificial blood for the purpose of blood transfusion

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the process of photosynthesis. Illustration: shutterstock

Turn off lights

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brain research. Illustration: shutterstock

What does not kill you…

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The process of repair through nucleotide excision that earned its discoverers the Nobel Prize in Chemistry for 2015. From the Nobel Prize website

Nobel Prize in Chemistry for discoverers of DNA repair mechanisms

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Hydrophilic carbon aggregate together with polyethylene glycol developed at Rice University has the potential to moderate the overexpression of harmful superoxides through the conversion of active oxygen species that may harm biological functions into neutral oxygen molecules. [Courtesy of Errol Samuel/Rice University]

The great potential of nano-antioxidants

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Illustration: shutterstock

Diseases caused by smoking

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One of the enzymes from the superoxide dismutase family. The medicine for eternal life, or a deadly poison? Source: Wikipedia.

Longevity, Part 4 When Breathing Kills: Free Radicals and Aging

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PhD student Maya Shoshan. Photo: Daniel Wiseman

Researchers at Tel Aviv University have revealed the mechanism responsible for introducing copper ions into the cell

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