proteasome

A ubiquitin molecule binds to its target. Illustration: depositphotos.com

The protein that is (sometimes) to blame for Alzheimer's disease

A distorted version of a protein that marks damaged proteins causes the formation of deposits in the brain similar to what occurs in Alzheimer's disease
Tissues removed from mice implanted with lung cancer cells engineered to produce high amounts of PSME4 (left column) or unmodified cancer cells (right column). When the protein is expressed in a high amount, the tumor is larger (top row, the tumor cells are marked in intense and concentrated purple), the number of T cells that can fight the tumor is lower (middle row, in white), and there are more cells that suppress the immune response (bottom row, in green)

The cancer to the basket and eliminated

The cell's garbage disposal system changes in cancer and allows it to escape the immune system
Professor Michael Glickman. Photo: Technion spokespeople

The Technion researchers discovered that the mechanism that removes damaged proteins "goes on hiatus" in times of stress

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