Comprehensive coverage

A nanotechnological biochip for detecting minimal levels of disease markers

In a study published long ago in the scientific journal Nano Covergence, the researchers demonstrated the use of gold nanoparticles to increase the response of the sensor signal in their device to detect cancer, as part of the other findings

(a) Schematic description of the preparation of the biosensor: (1) gold electrodes; (2) insertion of a first layer on the gold surface; (3) coupling of antigen-antibody on the electrode; (b) a realistic image of the biosensor containing micro- Canals
(a) Schematic description of the preparation of the biosensor: (1) gold electrodes; (2) insertion of a first layer on the gold surface; (3) coupling of antigen-antibody on the electrode; (b) a realistic image of the biosensor containing micro- Canals

[Translation by Dr. Nachmani Moshe]
Using a novel electrochemical biosensing device that detects the tiniest signs of disease biomarkers, for example, cancer, the inventors hope to detect minute amounts of early signs of disease in the bloodstream
The difficulty of detecting minute amounts of signs of the disease in the bloodstream has been proven to be a serious obstacle in the field of cancer detection and treatment when the tumor progresses stealthily and exhibits few symptoms. Using a novel electrochemical biosensing device that detects the tiniest signs of disease biomarkers, for example, cancer, the inventors hope to detect minute amounts of early signs of disease. The researchers' achievements in the field of disease detection are a demonstration of the power of electrical sensing - and the growing importance of engineers - in medical research.

"Ideally, a simple and cheap test will be possible - which can be performed routinely during a patient's visits even in the absence of symptoms - in order to scan and identify some of the more deadly and silent types of cancer," said the chief researcher. The researchers' device includes a microfluidic channel through which small amounts of blood flow through a sensing substrate coated with biological materials that bind to specific biomarkers of disease, biomarkers found in body fluids such as blood, tears and urine - a link that initiates the closure of an electrical nanocircuit that emits signals are defined.

Early detection of cancer. Illustration: Image by mohamed Hassan from Pixabay
Early detection of cancer. Illustration: Image by mohamed hassan from Pixabay

As part of a study published long ago in the scientific journal Nano Covergence, the researchers demonstrated the use of gold nanoparticles in order to increase the response of the sensor signal in their device to detect cancer, as part of the other findings. One of the core advantages of this device is its ability to separate blood fluid (plasma) from whole blood within its microfluidic channels. The blood plasma stores within it the biomarkers for diseases and therefore it is required to be separated in order to increase the "signal to noise ratio" in order to obtain a test with great accuracy. The device enables the analysis of a blood sample within two minutes without the need for any external equipment. "Our approach makes it possible to identify defined biomarkers at femto concentration levels, which is a level lower than the nano and even pico level. Existing sensing technologies are limited to a scale one thousand times larger than the new one. The use of this nanometer system allows us to detect low levels of disease markers", explains the researcher, "and by separating the plasma from the blood we can target the disease biomarkers". In another recent article by the same team of researchers, published in the scientific journal BioNanoScience, the researchers detailed their findings about differences in sensitivity levels based on microfluidic flow. The researcher is currently participating in similar studies in the field of "chip-on-organ" while producing organoids (artificial organs consisting of culture cells fixed within structural hydrogels) bioprinted in XNUMXD - for the purpose of conducting medical experiments.

"Now, says the lead researcher, I am the main person responsible for the development of the microfluidic devices that will enable the automation of the XNUMXD printing process of the organs that will be integrated into a chip intended for several applications. Right now, for example, I am busy developing an automated system to analyze the effectiveness and toxicity of drugs in order to identify biomarkers of liver cancer and heart disease. "My goal is to integrate the microfluidic biosensor into a liver cancer and heart disease model on a "heart-on-a-chip" for continued monitoring," explains the researcher. By measuring the concentrations of the biomarkers secreted from three-dimensional organs into which drugs have been injected, we can examine their effects on different organs, without harming the living patient. The production of artificial organs allows us to perform experiments without limitations." In the next step, the researchers say, the system could be applied in the field of regenerative medicine. "Our goal is to develop organoids and tissues of clinical importance, fully functional, created with the help of XNUMXD bioprinting, in order to solve the problem of a shortage of organs for transplantation."

In its current form, the device will be able to provide both quantitative and qualitative results regarding cancer antigens found in blood samples, while providing information regarding the presence and degree of severity of the cancer tumor. Their next step, the researchers say, is to expand their system so that it can detect multiple diseases using a single blood sample.

"As we all know, early diagnosis may significantly improve the results of patient treatment," adds the researcher. "Today, doctors rely on diagnostic devices that require a wait of at least four hours for the preparation of the sample and its examination within the framework of central rather than regional diagnostic centers. Our device will be able to significantly improve this situation."

The full article

The news about the study

More of the topic in Hayadan:

Leave a Reply

Email will not be published. Required fields are marked *

This site uses Akismat to prevent spam messages. Click here to learn how your response data is processed.