New research at the Ruth and Baruch Rappaport Faculty of Medicine at the Technion, published in JACC-CardioOncology, offers a breakthrough in understanding the bidirectional relationship between heart failure and cancer and indicates the potential for innovative treatments against fibrosis and improving heart function.
Prof. Ami Aharonheim, Dean of the Ruth and Baruch Rappaport Faculty of Medicine, presents a series of groundbreaking findings that represent a turning point in the understanding of the links between heart disease and cancer. The article is published בJACC-CardioOncolgy , a prestigious journal from the American College of Cardiology, considered one of the world's leading platforms in the field of cardio-oncology.
The study was led by Prof. Aharonheim with doctoral students Lama Awad and Lis Akhlaoug. In the article, they review the bidirectional relationship between heart failure and cancer. According to Prof. Aharonheim: "The connection between the diseases has been known for years, and from this a new field of research was born: cardio-oncology. Our goal is to uncover additional connections in this context and to understand in depth the connecting mechanisms. Such an understanding will pave the way for innovative treatments that will benefit patients from both groups."
Both diseases share common risk factors, including smoking, obesity, sedentary lifestyle, diabetes, genetic factors, and high blood pressure. The diseases also share a common involvement in chronic inflammation, changes in the immune system, and changes in the intercellular space that affect tissue stiffness. It is known that anticancer treatments may impair cardiac function, and that cardiovascular disease can accelerate cancer progression, cell migration, and metastasis.
The scientific innovation in Prof. Aharonheim's research is the surprising discovery thatCancer development may, in the absence of anti-cancer treatments, improve heart function and reduce fibrosis – the process of scar tissue formation in the heart muscle. Currently, there are no drugs that can break down fibrosis or directly improve the contractile ability of the heart muscle, and these findings pave the way for the development of new and groundbreaking therapeutic approaches.
The study was supported by the Rappaport Institute for Research and Medical Sciences.
To the article B-JACC-CardioOncolgy – Click HERE
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One response
Just a waste of research money. 2 different diseases, the connection between them depends only on the use of drugs. As we know, there is no heart cancer. Any connection is designed to promote idle gossip.